Protein: O94906 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O94906 (Uniprot)	PRP6_HUMAN	PRPF6	Pre-mRNA-processing factor 6	human	No

Protein Function

Uniprot: Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	353	GO:0019538	protein metabolic process	775	1.88e-02	4.66e-37
GO:0007165	signal transduction	282	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	353	4.83e-02	1.79e-71

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
282	GO:0035556	intracellular signal transduction
282	GO:0043085	positive regulation of catalytic activity
282	GO:0031325	positive regulation of cellular metabolic process
282	GO:0051173	positive regulation of nitrogen compound metabolic process
282	GO:0060255	regulation of macromolecule metabolic process
282	GO:0019220	regulation of phosphate metabolic process
353	GO:0000398	mRNA splicing, via spliceosome
747	GO:0010467	gene expression
747	GO:0090304	nucleic acid metabolic process
775	GO:0044267	cellular protein metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
282	GO:0005829	cytosol
282	GO:0005886	plasma membrane
353	GO:0005654	nucleoplasm
747	GO:0070013	intracellular organelle lumen
747	GO:0005634	nucleus
775	GO:0005829	cytosol
775	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000244	spliceosomal tri-snRNP complex assembly	IMP
GO:0000245	spliceosomal complex assembly	NAS
GO:0000375	RNA splicing, via transesterification reactions	NAS
GO:0000398	mRNA splicing, via spliceosome	TAS
GO:0006403	RNA localization	IMP
GO:0008380	RNA splicing	NAS
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005681	spliceosomal complex	NAS
GO:0005682	U5 snRNP	IDA
GO:0016020	membrane	IDA
GO:0016607	nuclear speck	IDA
GO:0046540	U4/U6 x U5 tri-snRNP complex	IDA
GO:0071013	catalytic step 2 spliceosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005654	nucleoplasm	GO:0016020	membrane	5.76e-255	1.32e-206
GO:0005681	spliceosomal complex	GO:0016020	membrane	6.04e-13	3.30e-19
GO:0016020	membrane	GO:0016607	nuclear speck	9.49e-26	4.88e-97

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433B_HUMAN	No
AASD1_HUMAN	No
ARAF_HUMAN	No
CD2B2_HUMAN	No
MDM2_HUMAN	Yes: Q00987 (MoonDB)
MLF2_HUMAN	Yes: Q15773 (MoonDB)
PRP31_HUMAN	No
PRP8_HUMAN	No
PSMD2_HUMAN	Yes: Q13200 (MoonDB)
RAF1_HUMAN	Yes: P04049 (MoonDB)

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Publications Associated

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PMID	Article Title
10561546	A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors.
10788320	The human homologue of the yeast splicing factor Prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions.
10848612	Isoform-specific localization of A-RAF in mitochondria.
11780052	The DNA sequence and comparative analysis of human chromosome 20.
11991638	Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
12039962	Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16723661	The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.
17974005	The full-ORF clone resource of the German cDNA consortium.

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OMIM Diseases Associated

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OMIM ID	Disease Name
613983	Retinitis pigmentosa 60

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Protein Domains Associated

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Domain Name	Domain ID	Source
HAT	IPR003107	InterPro
HAT	SM00386	SMART
PRP1_N	IPR010491	InterPro
PRP1_N	PF06424	Pfam
Prp6/Prp1/STA1	IPR027108	InterPro
PTHR11246:SF1	PTHR11246:SF1	PANTHER
SSF48452	SSF48452	SUPFAM
T46386	T46386	PIR
TPR	SM00028	SMART
TPR-contain_dom	IPR013026	InterPro

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