1614537 |
Amplification of a gene encoding a p53-associated protein in human sarcomas. |
7651818 |
A functional p53-responsive intronic promoter is contained within the human mdm2 gene. |
7689721 |
Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes. |
8705862 |
Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. |
8875929 |
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. |
9270029 |
Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein. |
9450543 |
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. |
10597303 |
A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein. |
10608892 |
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. |
10611322 |
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. |
10707090 |
Identification of a cryptic nucleolar-localization signal in MDM2. |
10722742 |
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. |
10723139 |
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. |
11087894 |
A MboII polymorphism in exon 11 of the human MDM2 gene occurring in normal blood donors and in soft tissue sarcoma patients: an indication for an increased cancer susceptibility? |
11351297 |
Analysis of the molecular species generated by MDM2 gene amplification in liposarcomas. |
12167711 |
Hypophosphorylation of Mdm2 augments p53 stability. |
12821780 |
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. |
12883554 |
A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter. |
14702039 |
Complete sequencing and characterization of 21,243 full-length human cDNAs. |
15053880 |
A dynamic role of HAUSP in the p53-Mdm2 pathway. |
15195100 |
PML regulates p53 stability by sequestering Mdm2 to the nucleolus. |
15313915 |
Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells. |
15315825 |
Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs. |
15364927 |
Negative regulation of p53 functions by Daxx and the involvement of MDM2. |
15489334 |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15550242 |
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. |
15632057 |
Regulation of p53 and MDM2 activity by MTBP. |
15878855 |
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. |
16173922 |
A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. |
16219768 |
WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. |
16337594 |
MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. |
16402859 |
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. |
16474402 |
Molecular recognition of p53 and MDM2 by USP7/HAUSP. |
16479015 |
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. |
16541075 |
The finished DNA sequence of human chromosome 12. |
16845383 |
Critical role for Daxx in regulating Mdm2. |
17003841 |
The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes. |
17110379 |
A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. |
17290220 |
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. |
17460193 |
CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor-suppressor pathway. |
17470788 |
PACT is a negative regulator of p53 and essential for cell growth and embryonic development. |
18382127 |
CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2. |
18566590 |
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. |
18768758 |
AAA ATPase p97 and adaptor UBXD1 suppress MDM2 ubiquitination and degradation and promote constitutive p53 turnover. |
19098711 |
RYBP stabilizes p53 by modulating MDM2. |
19139490 |
A strategy for precise and large scale identification of core fucosylated glycoproteins. |
19219073 |
Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway. |
19369353 |
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. |
19690332 |
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. |
19756449 |
Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation. |
19816404 |
ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. |
19837670 |
MTA1 coregulator regulates p53 stability and function. |
19838211 |
MdmX is a substrate for the deubiquitinating enzyme USP2a. |
19965871 |
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. |
20173098 |
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. |
20385133 |
p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma. |
20858735 |
Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. |
21333377 |
Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2. |
22128911 |
Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. |
22869143 |
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction. |
23186163 |
Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
24120868 |
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. |