Protein: P49407

Uniprot: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; t more..

Function 1: Endocytic function, cytosolic regulator and scaffold of GPCR signaling. Condition: present in plasma membrane or cytoplasm.

Function 2: Positive regulation of transcription from RNA polymerase II promoter by facilitating the binding of transcription factors. Condition: nuclear localisation.

Publications (PMID): 26909598, 24837709

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