Protein: P60953

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P60953 (Uniprot) CDC42_HUMAN CDC42 Cell division control protein 42 homolog human No
Uniprot: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0010646 regulation of cell communication 284 GO:0034641 cellular nitrogen compound metabolic process 477 1.59e-39 2.52e-03
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
2 GO:0044267 cellular protein metabolic process
2 GO:0010467 gene expression
2 GO:0006139 nucleobase-containing compound metabolic process
2 GO:0060255 regulation of macromolecule metabolic process
2 GO:0007165 signal transduction
51 GO:0060255 regulation of macromolecule metabolic process
115 GO:0006464 cellular protein modification process
115 GO:0060255 regulation of macromolecule metabolic process
128 GO:0007165 signal transduction
129 GO:0044267 cellular protein metabolic process
129 GO:0007165 signal transduction
175 GO:0044267 cellular protein metabolic process
175 GO:0006139 nucleobase-containing compound metabolic process
175 GO:0010468 regulation of gene expression
217 GO:0060255 regulation of macromolecule metabolic process
217 GO:0007165 signal transduction
284 GO:0009966 regulation of signal transduction
305 GO:0060255 regulation of macromolecule metabolic process
337 GO:0022607 cellular component assembly
337 GO:0035556 intracellular signal transduction
337 GO:0006468 protein phosphorylation
337 GO:0060255 regulation of macromolecule metabolic process
358 GO:0006464 cellular protein modification process
358 GO:0060255 regulation of macromolecule metabolic process
358 GO:0007165 signal transduction
432 GO:0007165 signal transduction
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
477 GO:0044271 cellular nitrogen compound biosynthetic process
477 GO:0090304 nucleic acid metabolic process
477 GO:1901362 organic cyclic compound biosynthetic process
477 GO:2000112 regulation of cellular macromolecule biosynthetic process
477 GO:0007165 signal transduction
664 GO:0044267 cellular protein metabolic process
664 GO:0010467 gene expression
664 GO:0090304 nucleic acid metabolic process
664 GO:0060255 regulation of macromolecule metabolic process
664 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
2 GO:0005829 cytosol
2 GO:0005634 nucleus
51 GO:0005634 nucleus
115 GO:0005829 cytosol
115 GO:0005634 nucleus
128 GO:0012505 endomembrane system
128 GO:0016021 integral component of membrane
128 GO:0005886 plasma membrane
129 GO:0005829 cytosol
129 GO:0070013 intracellular organelle lumen
175 GO:0005829 cytosol
175 GO:0005634 nucleus
217 GO:0005829 cytosol
217 GO:0043232 intracellular non-membrane-bounded organelle
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
305 GO:0005634 nucleus
337 GO:0005829 cytosol
337 GO:0043232 intracellular non-membrane-bounded organelle
337 GO:0005634 nucleus
358 GO:0012505 endomembrane system
358 GO:0005615 extracellular space
358 GO:0005886 plasma membrane
358 GO:0031982 vesicle
432 GO:0005829 cytosol
432 GO:0005886 plasma membrane
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
477 GO:0005829 cytosol
477 GO:0070013 intracellular organelle lumen
477 GO:0044428 nuclear part
664 GO:0005829 cytosol
664 GO:0043232 intracellular non-membrane-bounded organelle
664 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002040 sprouting angiogenesis IEA
GO:0003161 cardiac conduction system development IEA
GO:0003334 keratinocyte development IEA
GO:0006468 protein phosphorylation IEA
GO:0006911 phagocytosis, engulfment IMP
GO:0007015 actin filament organization IMP
GO:0007030 Golgi organization ISS
GO:0007088 regulation of mitotic nuclear division IEA
GO:0007097 nuclear migration IEA
GO:0007163 establishment or maintenance of cell polarity TAS
GO:0007229 integrin-mediated signaling pathway IMP
GO:0007596 blood coagulation TAS
GO:0010591 regulation of lamellipodium assembly IGI
GO:0010592 positive regulation of lamellipodium assembly IMP
GO:0010628 positive regulation of gene expression IEA
GO:0010629 negative regulation of gene expression IEA
GO:0016567 protein ubiquitination IEA
GO:0021762 substantia nigra development IEP
GO:0030036 actin cytoskeleton organization IDA
GO:0030225 macrophage differentiation TAS
GO:0030307 positive regulation of cell growth IMP
GO:0031069 hair follicle morphogenesis IEA
GO:0031274 positive regulation of pseudopodium assembly IDA
GO:0031295 T cell costimulation TAS
GO:0031333 negative regulation of protein complex assembly IPI
GO:0031424 keratinization IEA
GO:0031647 regulation of protein stability IEA
GO:0032467 positive regulation of cytokinesis IMP
GO:0032488 Cdc42 protein signal transduction IEA
GO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
GO:0034329 cell junction assembly IMP
GO:0034332 adherens junction organization IEA
GO:0034613 cellular protein localization IEA
GO:0035264 multicellular organism growth IEA
GO:0035722 interleukin-12-mediated signaling pathway TAS
GO:0036336 dendritic cell migration IEA
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0038189 neuropilin signaling pathway IMP
GO:0039694 viral RNA genome replication IMP
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
GO:0042176 regulation of protein catabolic process IEA
GO:0043497 regulation of protein heterodimerization activity IEA
GO:0043525 positive regulation of neuron apoptotic process IEA
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
GO:0045198 establishment of epithelial cell apical/basal polarity IMP
GO:0045740 positive regulation of DNA replication IEA
GO:0045859 regulation of protein kinase activity IEA
GO:0046330 positive regulation of JNK cascade IEA
GO:0046847 filopodium assembly IEA
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0048013 ephrin receptor signaling pathway TAS
GO:0048664 neuron fate determination IEA
GO:0051017 actin filament bundle assembly IEA
GO:0051056 regulation of small GTPase mediated signal transduction TAS
GO:0051149 positive regulation of muscle cell differentiation TAS
GO:0051489 regulation of filopodium assembly IDA
GO:0051491 positive regulation of filopodium assembly IMP
GO:0051492 regulation of stress fiber assembly IGI
GO:0051496 positive regulation of stress fiber assembly IMP
GO:0051683 establishment of Golgi localization ISS
GO:0051835 positive regulation of synapse structural plasticity IEA
GO:0051988 regulation of attachment of spindle microtubules to kinetochore IMP
GO:0060047 heart contraction IEA
GO:0060070 canonical Wnt signaling pathway IEA
GO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis IEA
GO:0060661 submandibular salivary gland formation IEA
GO:0060684 epithelial-mesenchymal cell signaling IEA
GO:0060789 hair follicle placode formation IEA
GO:0060997 dendritic spine morphogenesis ISS
GO:0071338 positive regulation of hair follicle cell proliferation IEA
GO:0072384 organelle transport along microtubule ISS
GO:0090135 actin filament branching IEA
GO:0090136 epithelial cell-cell adhesion IEA
GO:0090316 positive regulation of intracellular protein transport IEA
GO:0099563 modification of synaptic structure IEA
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading IDA
GO:2000251 positive regulation of actin cytoskeleton reorganization IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000139 Golgi membrane ISS
GO:0000322 storage vacuole IEA
GO:0005737 cytoplasm IDA
GO:0005789 endoplasmic reticulum membrane TAS
GO:0005813 centrosome IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0005911 cell-cell junction IEA
GO:0005925 focal adhesion IDA
GO:0016020 membrane IDA
GO:0017119 Golgi transport complex IMP
GO:0030141 secretory granule IEA
GO:0030175 filopodium IDA
GO:0030496 midbody IDA
GO:0031256 leading edge membrane IEA
GO:0036464 cytoplasmic ribonucleoprotein granule IDA
GO:0043005 neuron projection IDA
GO:0043025 neuronal cell body IDA
GO:0043197 dendritic spine IDA
GO:0043209 myelin sheath IEA
GO:0043234 protein complex IDA
GO:0045177 apical part of cell IEA
GO:0051233 spindle midzone IDA
GO:0070062 extracellular exosome IDA
GO:0072686 mitotic spindle IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005789 endoplasmic reticulum membrane GO:0005813 centrosome 3.58e-03 3.24e-62
GO:0005789 endoplasmic reticulum membrane GO:0005829 cytosol 4.27e-12 7.53e-04
GO:0005813 centrosome GO:0005886 plasma membrane 6.39e-08 8.47e-54
Interactor Also a MoonDB EMF protein
PAK5_HUMAN No
KAT5_HUMAN No
A2MG_HUMAN Yes: P01023 (MoonDB)
ACK1_HUMAN No
ADIP_HUMAN Yes: Q9Y2D8 (MoonDB)
AGAP2_HUMAN No
APC_HUMAN No
APOH_HUMAN No
ARHG4_HUMAN No
ARHG6_HUMAN No
ARHGB_HUMAN No
ARRB1_HUMAN Yes: P49407 (MoonDB)
ARRB2_HUMAN Yes: P32121 (MoonDB)
BAIP2_HUMAN No
BNIP2_HUMAN No
BORG1_HUMAN No
BORG2_HUMAN No
BORG3_HUMAN No
BORG4_HUMAN No
BORG5_HUMAN No
C42S1_HUMAN No
C42S2_HUMAN No
CASB_HUMAN No
CASP3_HUMAN No
CBPN_HUMAN No
CIP4_HUMAN No
COX1_HUMAN No
DIAP2_HUMAN No
DNJA3_HUMAN No
DOCK8_HUMAN No
EF1G_HUMAN No
ERG28_HUMAN No
ETFA_HUMAN No
F10A1_HUMAN No
FETUA_HUMAN No
FHR4_HUMAN No
FMNL2_HUMAN No
GANP_HUMAN No
GDIR1_HUMAN No
GDS1_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
HERC2_HUMAN No
ITSN1_HUMAN No
K2026_HUMAN No
KAT6B_HUMAN Yes: Q8WYB5 (MoonDB)
KPCI_HUMAN No
KS6B1_HUMAN No
LCK_HUMAN No
LEG1_HUMAN Yes: P09382 (MoonDB)
LRIF1_HUMAN No
M3K10_HUMAN No
M3K11_HUMAN No
M3K4_HUMAN No
MCF2L_HUMAN No
MK08_HUMAN No
MK09_HUMAN No
MRCKA_HUMAN No
MRCKB_HUMAN No
MRCKG_HUMAN No
MUC12_HUMAN No
MYO6_HUMAN No
MYO9A_HUMAN No
NCF2_HUMAN No
NEK6_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
PAK1_HUMAN Yes: Q13153 (MoonDB)
PAK2_HUMAN No
PAK3_HUMAN No
PAK4_HUMAN No
PAK6_HUMAN No
PAR6A_HUMAN No
PAR6B_HUMAN No
PAR6G_HUMAN No
PDE6D_HUMAN No
PTN2_HUMAN No
RHG01_HUMAN No
RHG32_HUMAN No
RIF1_HUMAN No
RIOK3_HUMAN No
RL22_HUMAN No
RL23_HUMAN No
S10A9_HUMAN No
SH319_HUMAN No
SPT13_HUMAN No
SYNE1_HUMAN No
U119A_HUMAN No
UBC_HUMAN Yes: P0CG48 (MoonDB)
UBR1_HUMAN No
VAV_HUMAN No
VRK2_HUMAN No
WASL_HUMAN No
WASP_HUMAN No
ZN175_HUMAN No
ZN234_HUMAN No
ZN420_HUMAN No
PMID Article Title
2122236 Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.
2124704 Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.
2496687 Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain.
7512369 Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.
8504089 Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.
9220962 Definition of the switch surface in the solution structure of Cdc42Hs.
9262406 Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
9760238 Identification of the binding surface on Cdc42Hs for p21-activated kinase.
10211824 Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.
10490598 The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.
10587647 Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
10676816 Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.
10816584 SPECs, small binding proteins for Cdc42.
10954424 The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.
11130076 IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.
11260256 Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.
11807099 The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.
12172552 Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
12612085 The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.
14506284 Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase.
14978216 Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15642749 Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
16710414 The DNA sequence and biological annotation of human chromosome 1.
17038317 Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.
19029984 Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
19039103 AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.
19362538 The fic domain: regulation of cell signaling by adenylylation.
19745154 Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
19798448 Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.
20622875 Structural basis of Fic-mediated adenylylation.
20873783 Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
21139582 The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.
21269460 Initial characterization of the human central proteome.
22461490 DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
23434736 ARHGDIA: a novel gene implicated in nephrotic syndrome.
24141704 A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.
25944712 N-terminome analysis of the human mitochondrial proteome.
26386261 Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: Yet another locus for thrombocytopenia and developmental delay.
26465210 Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.
26708094 Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia.
OMIM ID Disease Name
616737 Takenouchi-Kosaki syndrome
Domain Name Domain ID Source
A36382 A36382 PIR
A39265 A39265 PIR
Small_GTPase IPR001806 InterPro
Small_GTPase_Rho IPR003578 InterPro
Small_GTP-bd_dom IPR005225 InterPro
P-loop_NTPase IPR027417 InterPro
Ras PF00071 Pfam
RHO PS51420 PROSITE
SSF52540 SSF52540 SUPFAM
small_GTP TIGR00231 TIGRFAMs