Protein: P0CG48

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P0CG48 (Uniprot) UBC_HUMAN UBC Polyubiquitin-C human No
Uniprot: Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 243, 270 6.37e-04 1.88e-40
GO:0007165 signal transduction 255, 308 GO:0006139 nucleobase-containing compound metabolic process 444, 713 1.10e-111 5.07e-25
GO:0007165 signal transduction 255, 308 GO:0006725 cellular aromatic compound metabolic process 736 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
44 GO:0010467 gene expression
44 GO:0031324 negative regulation of cellular metabolic process
44 GO:0009889 regulation of biosynthetic process
44 GO:0060255 regulation of macromolecule metabolic process
48 GO:0044248 cellular catabolic process
48 GO:0070647 protein modification by small protein conjugation or removal
48 GO:0006508 proteolysis
48 GO:0060255 regulation of macromolecule metabolic process
48 GO:0007165 signal transduction
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
159 GO:0006464 cellular protein modification process
159 GO:0006355 regulation of transcription, DNA-templated
159 GO:0007165 signal transduction
197 GO:0044267 cellular protein metabolic process
197 GO:0060255 regulation of macromolecule metabolic process
217 GO:0060255 regulation of macromolecule metabolic process
217 GO:0007165 signal transduction
243 GO:0034645 cellular macromolecule biosynthetic process
243 GO:0044271 cellular nitrogen compound biosynthetic process
243 GO:0006464 cellular protein modification process
243 GO:0031325 positive regulation of cellular metabolic process
243 GO:0010604 positive regulation of macromolecule metabolic process
243 GO:0051173 positive regulation of nitrogen compound metabolic process
243 GO:0051252 regulation of RNA metabolic process
243 GO:0031326 regulation of cellular biosynthetic process
243 GO:0032268 regulation of cellular protein metabolic process
243 GO:0010468 regulation of gene expression
243 GO:0010556 regulation of macromolecule biosynthetic process
243 GO:0007165 signal transduction
249 GO:0060255 regulation of macromolecule metabolic process
253 GO:0019538 protein metabolic process
255 GO:0008283 cell proliferation
255 GO:0007166 cell surface receptor signaling pathway
255 GO:0006464 cellular protein modification process
255 GO:0060429 epithelium development
255 GO:0006139 nucleobase-containing compound metabolic process
255 GO:0006796 phosphate-containing compound metabolic process
255 GO:0006508 proteolysis
259 GO:0007165 signal transduction
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
283 GO:0006464 cellular protein modification process
283 GO:0060255 regulation of macromolecule metabolic process
300 GO:0016070 RNA metabolic process
300 GO:0044271 cellular nitrogen compound biosynthetic process
300 GO:0031325 positive regulation of cellular metabolic process
300 GO:0010604 positive regulation of macromolecule metabolic process
300 GO:0051173 positive regulation of nitrogen compound metabolic process
300 GO:2000112 regulation of cellular macromolecule biosynthetic process
300 GO:0010468 regulation of gene expression
300 GO:0019219 regulation of nucleobase-containing compound metabolic process
308 GO:0007166 cell surface receptor signaling pathway
308 GO:0071310 cellular response to organic substance
308 GO:0035556 intracellular signal transduction
308 GO:0043085 positive regulation of catalytic activity
308 GO:0031328 positive regulation of cellular biosynthetic process
308 GO:0010604 positive regulation of macromolecule metabolic process
308 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
308 GO:0009967 positive regulation of signal transduction
308 GO:0006468 protein phosphorylation
308 GO:0031399 regulation of protein modification process
308 GO:0006355 regulation of transcription, DNA-templated
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
360 GO:0060255 regulation of macromolecule metabolic process
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
404 GO:0044267 cellular protein metabolic process
404 GO:0007165 signal transduction
420 GO:0006464 cellular protein modification process
423 GO:0006464 cellular protein modification process
423 GO:0090304 nucleic acid metabolic process
423 GO:0060255 regulation of macromolecule metabolic process
444 GO:0090304 nucleic acid metabolic process
444 GO:0060255 regulation of macromolecule metabolic process
444 GO:0019219 regulation of nucleobase-containing compound metabolic process
444 GO:0007165 signal transduction
531 GO:0019538 protein metabolic process
540 GO:0022607 cellular component assembly
549 GO:0008219 cell death
549 GO:0070887 cellular response to chemical stimulus
549 GO:0033554 cellular response to stress
549 GO:0035556 intracellular signal transduction
549 GO:0031325 positive regulation of cellular metabolic process
549 GO:0010604 positive regulation of macromolecule metabolic process
549 GO:0051173 positive regulation of nitrogen compound metabolic process
549 GO:0048584 positive regulation of response to stimulus
549 GO:0006468 protein phosphorylation
549 GO:0051252 regulation of RNA metabolic process
549 GO:2000112 regulation of cellular macromolecule biosynthetic process
549 GO:0032268 regulation of cellular protein metabolic process
549 GO:0010468 regulation of gene expression
549 GO:0009966 regulation of signal transduction
549 GO:0006351 transcription, DNA-templated
555 GO:0006464 cellular protein modification process
555 GO:0060255 regulation of macromolecule metabolic process
555 GO:0007165 signal transduction
588 GO:0006355 regulation of transcription, DNA-templated
618 GO:0016070 RNA metabolic process
618 GO:0044271 cellular nitrogen compound biosynthetic process
618 GO:0006464 cellular protein modification process
618 GO:0070887 cellular response to chemical stimulus
618 GO:0006955 immune response
618 GO:0035556 intracellular signal transduction
618 GO:0031328 positive regulation of cellular biosynthetic process
618 GO:0010628 positive regulation of gene expression
618 GO:0002684 positive regulation of immune system process
618 GO:0010557 positive regulation of macromolecule biosynthetic process
618 GO:0051173 positive regulation of nitrogen compound metabolic process
618 GO:0048584 positive regulation of response to stimulus
618 GO:0006508 proteolysis
618 GO:0042981 regulation of apoptotic process
618 GO:2000112 regulation of cellular macromolecule biosynthetic process
618 GO:0019219 regulation of nucleobase-containing compound metabolic process
652 GO:0044267 cellular protein metabolic process
652 GO:0060255 regulation of macromolecule metabolic process
664 GO:0044267 cellular protein metabolic process
664 GO:0010467 gene expression
664 GO:0090304 nucleic acid metabolic process
664 GO:0060255 regulation of macromolecule metabolic process
664 GO:0007165 signal transduction
696 GO:0022607 cellular component assembly
696 GO:0006464 cellular protein modification process
696 GO:0060255 regulation of macromolecule metabolic process
696 GO:0007165 signal transduction
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
713 GO:0090304 nucleic acid metabolic process
713 GO:0070647 protein modification by small protein conjugation or removal
713 GO:0007165 signal transduction
736 GO:0006139 nucleobase-containing compound metabolic process
736 GO:0060255 regulation of macromolecule metabolic process
747 GO:0010467 gene expression
747 GO:0090304 nucleic acid metabolic process
774 GO:0006464 cellular protein modification process
774 GO:0060255 regulation of macromolecule metabolic process
807 GO:0070647 protein modification by small protein conjugation or removal
811 GO:0006955 immune response
811 GO:0019538 protein metabolic process
811 GO:0007165 signal transduction
819 GO:0010628 positive regulation of gene expression
819 GO:0019538 protein metabolic process
819 GO:0006355 regulation of transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
44 GO:0005829 cytosol
44 GO:0005634 nucleus
48 GO:0031410 cytoplasmic vesicle
48 GO:0012505 endomembrane system
48 GO:0005634 nucleus
48 GO:0005886 plasma membrane
105 GO:0005634 nucleus
125 GO:0005829 cytosol
125 GO:0005634 nucleus
134 GO:0005829 cytosol
134 GO:0005634 nucleus
159 GO:0005829 cytosol
159 GO:0005654 nucleoplasm
217 GO:0005829 cytosol
217 GO:0043232 intracellular non-membrane-bounded organelle
243 GO:0005829 cytosol
243 GO:0070013 intracellular organelle lumen
243 GO:0044428 nuclear part
249 GO:0005829 cytosol
249 GO:0005634 nucleus
249 GO:0031982 vesicle
255 GO:0012505 endomembrane system
255 GO:0016021 integral component of membrane
255 GO:0005886 plasma membrane
259 GO:0005886 plasma membrane
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
283 GO:0012505 endomembrane system
283 GO:0044428 nuclear part
300 GO:0070013 intracellular organelle lumen
300 GO:0044428 nuclear part
308 GO:0005829 cytosol
308 GO:0070013 intracellular organelle lumen
308 GO:0044428 nuclear part
308 GO:0005886 plasma membrane
359 GO:0005634 nucleus
361 GO:0005829 cytosol
368 GO:0005829 cytosol
368 GO:0005634 nucleus
368 GO:0031982 vesicle
375 GO:0005829 cytosol
375 GO:0005634 nucleus
404 GO:0005829 cytosol
404 GO:0012505 endomembrane system
404 GO:0031982 vesicle
420 GO:0005829 cytosol
420 GO:0005634 nucleus
423 GO:0005829 cytosol
423 GO:0005634 nucleus
444 GO:0005634 nucleus
501 GO:0031090 organelle membrane
540 GO:0005829 cytosol
540 GO:0043232 intracellular non-membrane-bounded organelle
540 GO:0005634 nucleus
549 GO:0005829 cytosol
549 GO:0005634 nucleus
555 GO:0005634 nucleus
588 GO:0031981 nuclear lumen
618 GO:0005829 cytosol
618 GO:0044421 extracellular region part
618 GO:0043232 intracellular non-membrane-bounded organelle
618 GO:0005654 nucleoplasm
618 GO:0005886 plasma membrane
618 GO:0031982 vesicle
652 GO:0005829 cytosol
652 GO:0005634 nucleus
652 GO:0031982 vesicle
664 GO:0005829 cytosol
664 GO:0043232 intracellular non-membrane-bounded organelle
664 GO:0005634 nucleus
696 GO:0005829 cytosol
696 GO:0043232 intracellular non-membrane-bounded organelle
696 GO:0005634 nucleus
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
713 GO:0005829 cytosol
713 GO:0005634 nucleus
736 GO:0005829 cytosol
736 GO:0070013 intracellular organelle lumen
736 GO:0044428 nuclear part
747 GO:0070013 intracellular organelle lumen
747 GO:0005634 nucleus
774 GO:0005634 nucleus
811 GO:0005829 cytosol
811 GO:0044428 nuclear part
819 GO:0098588 bounding membrane of organelle
819 GO:0005829 cytosol
819 GO:0012505 endomembrane system
819 GO:0005576 extracellular region
819 GO:0005634 nucleus
819 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000086 G2/M transition of mitotic cell cycle TAS
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS
GO:0000165 MAPK cascade TAS
GO:0000187 activation of MAPK activity TAS
GO:0000209 protein polyubiquitination TAS
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0005978 glycogen biosynthetic process TAS
GO:0006283 transcription-coupled nucleotide-excision repair TAS
GO:0006294 nucleotide-excision repair, preincision complex assembly TAS
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion TAS
GO:0006297 nucleotide-excision repair, DNA gap filling TAS
GO:0006457 protein folding TAS
GO:0006879 cellular iron ion homeostasis TAS
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
GO:0007179 transforming growth factor beta receptor signaling pathway TAS
GO:0007219 Notch signaling pathway TAS
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
GO:0007254 JNK cascade TAS
GO:0008543 fibroblast growth factor receptor signaling pathway TAS
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
GO:0016055 Wnt signaling pathway TAS
GO:0016197 endosomal transport TAS
GO:0016236 macroautophagy TAS
GO:0016567 protein ubiquitination TAS
GO:0016579 protein deubiquitination TAS
GO:0019058 viral life cycle TAS
GO:0019068 virion assembly TAS
GO:0019985 translesion synthesis TAS
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway TAS
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
GO:0032479 regulation of type I interferon production TAS
GO:0032480 negative regulation of type I interferon production TAS
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0033683 nucleotide-excision repair, DNA incision TAS
GO:0034220 ion transmembrane transport TAS
GO:0035635 entry of bacterium into host cell TAS
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
GO:0036297 interstrand cross-link repair TAS
GO:0038061 NIK/NF-kappaB signaling TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038128 ERBB2 signaling pathway TAS
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
GO:0042276 error-prone translesion synthesis TAS
GO:0042769 DNA damage response, detection of DNA damage TAS
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS
GO:0043065 positive regulation of apoptotic process TAS
GO:0043066 negative regulation of apoptotic process TAS
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
GO:0043488 regulation of mRNA stability TAS
GO:0044267 cellular protein metabolic process TAS
GO:0045087 innate immune response TAS
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway TAS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter TAS
GO:0050852 T cell receptor signaling pathway TAS
GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
GO:0051403 stress-activated MAPK cascade TAS
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
GO:0055085 transmembrane transport TAS
GO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
GO:0060544 regulation of necroptotic process TAS
GO:0061024 membrane organization TAS
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
GO:0070911 global genome nucleotide-excision repair TAS
GO:0070987 error-free translesion synthesis TAS
GO:0075733 intracellular transport of virus TAS
GO:0090090 negative regulation of canonical Wnt signaling pathway TAS
GO:0090263 positive regulation of canonical Wnt signaling pathway TAS
GO:1901796 regulation of signal transduction by p53 class mediator TAS
GO:1902036 regulation of hematopoietic stem cell differentiation TAS
GO:1904380 endoplasmic reticulum mannose trimming TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005615 extracellular space IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005741 mitochondrial outer membrane TAS
GO:0005789 endoplasmic reticulum membrane TAS
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0010008 endosome membrane TAS
GO:0030666 endocytic vesicle membrane TAS
GO:0031982 vesicle IDA
GO:0043657 host cell IEA
GO:0044322 endoplasmic reticulum quality control compartment IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005615 extracellular space GO:0005654 nucleoplasm 1.00e-49 3.88e-77
GO:0005634 nucleus GO:0005789 endoplasmic reticulum membrane 1.61e-25 3.10e-56
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0010008 endosome membrane 1.38e-08 8.40e-30
GO:0005634 nucleus GO:0030666 endocytic vesicle membrane 1.59e-05 7.63e-18
GO:0005634 nucleus GO:0031982 vesicle 1.94e-54 3.27e-93
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0005789 endoplasmic reticulum membrane 1.09e-31 5.14e-59
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0010008 endosome membrane 1.55e-05 2.28e-48
GO:0005654 nucleoplasm GO:0031982 vesicle 4.01e-60 1.21e-165
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
GO:0005789 endoplasmic reticulum membrane GO:0005829 cytosol 4.27e-12 7.53e-04
Interactor Also a MoonDB EMF protein
DAZP2_HUMAN Yes: Q15038 (MoonDB)
NEDD4_HUMAN No
UBQL2_HUMAN Yes: Q9UHD9 (MoonDB)
FAP20_HUMAN No
UBQL1_HUMAN No
XIAP_HUMAN Yes: P98170 (MoonDB)
BIRC7_HUMAN No
ZRAN1_HUMAN No
CTBP2_HUMAN No
PLS4_HUMAN No
NCK2_HUMAN Yes: O43639 (MoonDB)
OPTN_HUMAN No
TNIP1_HUMAN No
NEMO_HUMAN Yes: Q9Y6K9 (MoonDB)
CDC42_HUMAN Yes: P60953 (MoonDB)
TS101_HUMAN Yes: Q99816 (MoonDB)
HGS_HUMAN No
TOLIP_HUMAN No
F168A_HUMAN No
TOM1_HUMAN No
UBE3A_HUMAN Yes: Q05086 (MoonDB)
UBP2_HUMAN Yes: O75604 (MoonDB)
GRB2_HUMAN Yes: P62993 (MoonDB)
GGA1_HUMAN No
HSP7C_HUMAN Yes: P11142 (MoonDB)
STAM2_HUMAN No
PKHB2_HUMAN No
SH3K1_HUMAN No
STALP_HUMAN No
DAXX_HUMAN No
UBA1_HUMAN No
UBE2N_HUMAN Yes: P61088 (MoonDB)
UB2D2_HUMAN Yes: P62837 (MoonDB)
UB2E3_HUMAN Yes: Q969T4 (MoonDB)
DNJB2_HUMAN No
HDAC6_HUMAN No
NOD1_HUMAN No
ADRM1_HUMAN No
CACO2_HUMAN No
JOS1_HUMAN No
TNIP3_HUMAN No
APC11_HUMAN No
UBTD2_HUMAN No
UBE2K_HUMAN Yes: P61086 (MoonDB)
HOIL1_HUMAN No
RN114_HUMAN No
RD23A_HUMAN No
RABX5_HUMAN No
UBXN1_HUMAN No
TAXB1_HUMAN Yes: Q86VP1 (MoonDB)
SMAD1_HUMAN Yes: Q15797 (MoonDB)
TNIP2_HUMAN No
UB2D1_HUMAN Yes: P51668 (MoonDB)
UB2D3_HUMAN Yes: P61077 (MoonDB)
ABL1_HUMAN Yes: P00519 (MoonDB)
RD23B_HUMAN No
RNF11_HUMAN No
LCK_HUMAN No
CBL_HUMAN No
ZFAN6_HUMAN No
DLGP4_HUMAN No
JUN_HUMAN No
LAMB1_HUMAN No
UB2R1_HUMAN No
UB2R2_HUMAN No
OTUB2_HUMAN No
RAC1_HUMAN No
PLAP_HUMAN No
MTURN_HUMAN No
RNF31_HUMAN No
ADA19_HUMAN No
AMFR_HUMAN No
ANS1B_HUMAN No
ARRB2_HUMAN Yes: P32121 (MoonDB)
ATX3L_HUMAN No
ATX3_HUMAN No
BCR_HUMAN No
BRAP_HUMAN No
CCD50_HUMAN No
CD2AP_HUMAN No
CDIP1_HUMAN No
CLN8_HUMAN No
DESI1_HUMAN No
EPN2_HUMAN No
GGA3_HUMAN No
IDE_HUMAN No
KLF1_HUMAN No
MYO6_HUMAN No
NBR1_HUMAN No
NED4L_HUMAN No
NEDD8_HUMAN Yes: Q15843 (MoonDB)
NOD2_HUMAN No
NPL4_HUMAN No
OTU1_HUMAN No
OTU7B_HUMAN No
OTUB1_HUMAN No
OTUL_HUMAN No
POLH_HUMAN No
POLI_HUMAN No
PRKN_HUMAN No
PSMD4_HUMAN No
PTEN_HUMAN No
RAD18_HUMAN No
RGS2_HUMAN No
RIOK3_HUMAN No
RN115_HUMAN Yes: Q9Y4L5 (MoonDB)
RN165_HUMAN No
RYBP_HUMAN No
SFPQ_HUMAN No
SQSTM_HUMAN Yes: Q13501 (MoonDB)
STABP_HUMAN No
STAM1_HUMAN No
SYUA_HUMAN No
TAB2_HUMAN No
TAB3_HUMAN No
TNAP3_HUMAN No
TTC3_HUMAN No
UB2G2_HUMAN No
UB2V2_HUMAN No
UBAC1_HUMAN No
UBAP1_HUMAN No
UBE2B_HUMAN No
UBE2S_HUMAN No
UBFD1_HUMAN No
UBL7_HUMAN No
UBP28_HUMAN No
UBP5_HUMAN No
UBP8_HUMAN No
UBR5_HUMAN No
UCHL1_HUMAN No
UCHL3_HUMAN No
UFD1_HUMAN Yes: Q92890 (MoonDB)
UIMC1_HUMAN No
VPS36_HUMAN No
WDR48_HUMAN No
ZFAN3_HUMAN No
ZFAN5_HUMAN No
PMID Article Title
1128706 Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man.
2820408 Cloning and sequence analysis of a cDNA encoding poly-ubiquitin in human ovarian granulosa cells.
2988935 The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.
3041007 Structure of ubiquitin refined at 1.8-A resolution.
8107144 Structure of tetraubiquitin shows how multiubiquitin chains can be formed.
8166633 Synthetic, structural and biological studies of the ubiquitin system: the total chemical synthesis of ubiquitin.
8917096 Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells.
9504932 Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus.
9644242 Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product.
11173499 Structure of a new crystal form of tetraubiquitin.
12507430 Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.
14745543 Lineage-specific homogenization of the polyubiquitin gene among human and great apes.
15466860 Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16443603 Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.
16541075 The finished DNA sequence of human chromosome 12.
16543144 Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.
18719106 Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
19754430 The emerging complexity of protein ubiquitination.
20622874 Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.
21399617 Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.
23827681 OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
24660806 Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.
24751536 PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
24784582 Ubiquitin is phosphorylated by PINK1 to activate parkin.
25527291 Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.
28525742 Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.
No results found.
Domain Name Domain ID Source
UQHU A02574 PIR
UQHUC A22005 PIR
A29526 A29526 PIR
Ubiquitin_dom IPR000626 InterPro
Ubiquitin_CS IPR019954 InterPro
Ubiquitin IPR019956 InterPro
Ubiquitin-like_domsf IPR029071 InterPro
ubiquitin PF00240 Pfam
UBIQUITIN PR00348 PRINTS
UBIQUITIN_1 PS00299 PROSITE
UBIQUITIN_2 PS50053 PROSITE
UBQ SM00213 SMART
SSF54236 SSF54236 SUPFAM