Protein: P61077

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P61077 (Uniprot) UB2D3_HUMAN UBE2D3 Ubiquitin-conjugating enzyme E2 D3 human No
Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 270 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
175 GO:0044267 cellular protein metabolic process
175 GO:0006139 nucleobase-containing compound metabolic process
175 GO:0010468 regulation of gene expression
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
807 GO:0070647 protein modification by small protein conjugation or removal
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
134 GO:0005829 cytosol
134 GO:0005634 nucleus
175 GO:0005829 cytosol
175 GO:0005634 nucleus
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
359 GO:0005634 nucleus
375 GO:0005829 cytosol
375 GO:0005634 nucleus
575 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS
GO:0000209 protein polyubiquitination IDA
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0006281 DNA repair IEA
GO:0006464 cellular protein modification process TAS
GO:0006511 ubiquitin-dependent protein catabolic process TAS
GO:0006513 protein monoubiquitination IDA
GO:0006915 apoptotic process IEA
GO:0016567 protein ubiquitination TAS
GO:0030509 BMP signaling pathway TAS
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
GO:0051865 protein autoubiquitination IDA
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
GO:0070936 protein K48-linked ubiquitination IDA
GO:0070979 protein K11-linked ubiquitination IDA
GO:1903955 positive regulation of protein targeting to mitochondrion IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005654 nucleoplasm TAS
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IEA
GO:0010008 endosome membrane IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0010008 endosome membrane 1.55e-05 2.28e-48
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
Interactor Also a MoonDB EMF protein
TRI27_HUMAN Yes: P14373 (MoonDB)
NEDD4_HUMAN No
DTX2_HUMAN No
XIAP_HUMAN Yes: P98170 (MoonDB)
BIRC2_HUMAN No
BIRC7_HUMAN No
RNF5_HUMAN No
TRIM1_HUMAN Yes: Q9UJV3 (MoonDB)
SIAH1_HUMAN Yes: Q8IUQ4 (MoonDB)
TRI39_HUMAN No
ARI2_HUMAN No
TRI50_HUMAN No
STK25_HUMAN No
UBA1_HUMAN No
UBE2N_HUMAN Yes: P61088 (MoonDB)
UB2V1_HUMAN Yes: Q13404 (MoonDB)
DZIP3_HUMAN No
TRI37_HUMAN No
MKRN3_HUMAN Yes: Q13064 (MoonDB)
RNF38_HUMAN No
RN111_HUMAN Yes: Q6ZNA4 (MoonDB)
TRI18_HUMAN No
RNF37_HUMAN No
RNF4_HUMAN No
RING1_HUMAN No
LRSM1_HUMAN Yes: Q6UWE0 (MoonDB)
MARH3_HUMAN No
DTX3_HUMAN No
DTX3L_HUMAN No
TRI43_HUMAN No
RN125_HUMAN No
RN185_HUMAN No
BIRC8_HUMAN No
UHRF2_HUMAN No
RING2_HUMAN No
TRI31_HUMAN No
TRIM5_HUMAN Yes: Q9C035 (MoonDB)
TRIM2_HUMAN No
RN167_HUMAN Yes: Q9H6Y7 (MoonDB)
MARH7_HUMAN No
BFAR_HUMAN No
TRI35_HUMAN No
RN114_HUMAN No
TRI17_HUMAN No
TRI38_HUMAN No
BRCA1_HUMAN No
RLA1_HUMAN No
RN103_HUMAN No
AMFR_HUMAN No
BIRC3_HUMAN No
BMI1_HUMAN No
BRX1_HUMAN No
CAPS2_HUMAN No
CHFR_HUMAN No
CNOT4_HUMAN No
DREB_HUMAN No
DTX1_HUMAN No
FOCAD_HUMAN No
GOLI_HUMAN No
K1107_HUMAN No
M3K1_HUMAN No
MEX3B_HUMAN No
MGRN1_HUMAN No
MIB1_HUMAN No
MKRN1_HUMAN No
MUL1_HUMAN No
OTUB1_HUMAN No
PDCD5_HUMAN No
PJA2_HUMAN No
Q8NEX1_HUMAN No
RFWD3_HUMAN No
RL28_HUMAN No
RL40_HUMAN No
RMD5B_HUMAN No
RN115_HUMAN Yes: Q9Y4L5 (MoonDB)
RN126_HUMAN No
RN146_HUMAN No
RN150_HUMAN No
RN165_HUMAN No
RN166_HUMAN No
RN181_HUMAN No
RNF10_HUMAN No
RNF11_HUMAN No
RNF12_HUMAN No
RNF13_HUMAN No
RNF14_HUMAN No
RNF25_HUMAN No
RNF26_HUMAN No
RNF43_HUMAN No
RSPRY_HUMAN No
SNURF_HUMAN No
STAU1_HUMAN No
TBA1A_HUMAN No
TERT_HUMAN No
TOPRS_HUMAN No
TRAF6_HUMAN Yes: Q9Y4K3 (MoonDB)
TRI10_HUMAN No
TRI11_HUMAN No
TRI25_HUMAN No
TRI26_HUMAN No
TRI45_HUMAN No
TRI55_HUMAN No
TRI62_HUMAN No
TRIM7_HUMAN No
TRIM8_HUMAN Yes: Q9BZR9 (MoonDB)
UBC_HUMAN Yes: P0CG48 (MoonDB)
UBE4A_HUMAN No
UBE4B_HUMAN No
UBTD1_HUMAN No
UFL1_HUMAN No
UFM1_HUMAN No
XPP1_HUMAN No
ZNRF1_HUMAN No
ZNRF2_HUMAN No
ZNRF4_HUMAN No
PMID Article Title
8530467 Identification of a family of closely related human ubiquitin conjugating enzymes.
10329681 Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.
11743028 CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein.
12646252 Mammalian Numb is a target protein of Mdm2, ubiquitin ligase.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15247280 Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.
15280377 Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15496420 The poxvirus p28 virulence factor is an E3 ubiquitin ligase.
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
16543155 A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination.
16628214 A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.
17588522 E3-independent monoubiquitination of ubiquitin-binding proteins.
18284575 Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions.
18508924 Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation.
18515077 Physical and functional interactions between ZIP kinase and UbcH5.
18851830 Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.
18948756 PCNA is ubiquitinated by RNF8.
20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
20347421 Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.
20525694 The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.
21269460 Initial characterization of the human central proteome.
21532592 UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.
24211586 The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.
No results found.
Domain Name Domain ID Source
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD