Protein: Q969T4 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q969T4 (Uniprot)	UB2E3_HUMAN	UBE2E3	Ubiquitin-conjugating enzyme E2 E3	human	No

Protein Function

Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	270	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 26 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
48	GO:0044248	cellular catabolic process
48	GO:0070647	protein modification by small protein conjugation or removal
48	GO:0006508	proteolysis
48	GO:0060255	regulation of macromolecule metabolic process
48	GO:0007165	signal transduction
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
270	GO:0034645	cellular macromolecule biosynthetic process
270	GO:0010467	gene expression

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Cellular Components

Showing 1 to 10 of 18 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
48	GO:0031410	cytoplasmic vesicle
48	GO:0012505	endomembrane system
48	GO:0005634	nucleus
48	GO:0005886	plasma membrane
125	GO:0005829	cytosol
125	GO:0005634	nucleus
270	GO:0005829	cytosol
270	GO:0070013	intracellular organelle lumen
270	GO:0005634	nucleus
354	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 5 of 5 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0016567	protein ubiquitination	TAS
GO:0040008	regulation of growth	IEA
GO:0070534	protein K63-linked ubiquitination	IDA
GO:0070936	protein K48-linked ubiquitination	IDA
GO:0070979	protein K11-linked ubiquitination	IDA

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Cellular Components

Showing 1 to 2 of 2 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005654	nucleoplasm	TAS
GO:0005829	cytosol	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 76 entries

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Interactor	Also a MoonDB EMF protein
A2012_HUMAN	No
ARI2_HUMAN	No
ARI3A_HUMAN	No
ARRD1_HUMAN	No
ARRD3_HUMAN	No
ATX1_HUMAN	Yes: P54253 (MoonDB)
AUP1_HUMAN	No
BRCA1_HUMAN	No
CAPS2_HUMAN	No
CE192_HUMAN	No

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Publications Associated

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PMID	Article Title
10343118	cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin-conjugating enzyme.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15545318	Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import.
15815621	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20061386	The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
21269460	Initial characterization of the human central proteome.
24275569	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 8 of 8 entries

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Domain Name	Domain ID	Source
SSF54495	SSF54495	SUPFAM
UBCc	cd00195	CDD
UBIQUITIN_CONJUGAT_1	PS00183	PROSITE
UBIQUITIN_CONJUGAT_2	PS50127	PROSITE
UBQ-conjugat_E2	IPR000608	InterPro
UBQ-conjugating_AS	IPR023313	InterPro
UBQ-conjugating_enzyme/RWD	IPR016135	InterPro
UQ_con	PF00179	Pfam

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