Protein: Q969T4

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q969T4 (Uniprot) UB2E3_HUMAN UBE2E3 Ubiquitin-conjugating enzyme E2 E3 human No
Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 270 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
48 GO:0044248 cellular catabolic process
48 GO:0070647 protein modification by small protein conjugation or removal
48 GO:0006508 proteolysis
48 GO:0060255 regulation of macromolecule metabolic process
48 GO:0007165 signal transduction
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
354 GO:0090304 nucleic acid metabolic process
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
452 GO:0090304 nucleic acid metabolic process
452 GO:0010468 regulation of gene expression
452 GO:0007165 signal transduction
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
596 GO:0006464 cellular protein modification process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
48 GO:0031410 cytoplasmic vesicle
48 GO:0012505 endomembrane system
48 GO:0005634 nucleus
48 GO:0005886 plasma membrane
125 GO:0005829 cytosol
125 GO:0005634 nucleus
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
354 GO:0005634 nucleus
359 GO:0005634 nucleus
375 GO:0005829 cytosol
375 GO:0005634 nucleus
452 GO:0005829 cytosol
452 GO:0070013 intracellular organelle lumen
452 GO:0044428 nuclear part
575 GO:0005654 nucleoplasm
596 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0016567 protein ubiquitination TAS
GO:0040008 regulation of growth IEA
GO:0070534 protein K63-linked ubiquitination IDA
GO:0070936 protein K48-linked ubiquitination IDA
GO:0070979 protein K11-linked ubiquitination IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005654 nucleoplasm TAS
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
10343118 cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin-conjugating enzyme.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15545318 Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import.
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
21269460 Initial characterization of the human central proteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD