Protein: Q6ZNA4

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q6ZNA4 (Uniprot) RN111_HUMAN RNF111 E3 ubiquitin-protein ligase Arkadia human No
Uniprot: E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 192, 270 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
192 GO:0034645 cellular macromolecule biosynthetic process
192 GO:0006464 cellular protein modification process
192 GO:0010467 gene expression
192 GO:0090304 nucleic acid metabolic process
192 GO:0009893 positive regulation of metabolic process
192 GO:0060255 regulation of macromolecule metabolic process
192 GO:0007165 signal transduction
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
125 GO:0005829 cytosol
125 GO:0005634 nucleus
192 GO:0005829 cytosol
192 GO:0005654 nucleoplasm
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000209 protein polyubiquitination IBA
GO:0007389 pattern specification process IEA
GO:0016567 protein ubiquitination IMP
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IBA
GO:0030579 ubiquitin-dependent SMAD protein catabolic process IBA
GO:0031398 positive regulation of protein ubiquitination IEA
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
GO:0045893 positive regulation of transcription, DNA-templated IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter TAS
GO:0070911 global genome nucleotide-excision repair TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IBA
GO:0005829 cytosol IDA
GO:0016605 PML body IEA
GO:0043234 protein complex IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
14657019 Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16572171 Analysis of the DNA sequence and duplication history of human chromosome 15.
16601693 Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.
17591695 Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
17974005 The full-ORF clone resource of the German cDNA consortium.
22411132 NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase.
23086935 PolySUMO-binding proteins identified through a string search.
23751493 RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.
25755297 System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
26656854 Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
Znf_RING IPR001841 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
RNF111_N IPR029306 InterPro
zf-RING_2 PF13639 Pfam
RNF111_N PF15303 Pfam
ZF_RING_2 PS50089 PROSITE
RING SM00184 SMART
T46904 T46904 PIR