Protein: P51965 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P51965 (Uniprot)	UB2E1_HUMAN	UBE2E1	Ubiquitin-conjugating enzyme E2 E1	human	No

Protein Function

Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	192, 270	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 26 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
53	GO:0006139	nucleobase-containing compound metabolic process
53	GO:0016567	protein ubiquitination
53	GO:0060255	regulation of macromolecule metabolic process
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
192	GO:0034645	cellular macromolecule biosynthetic process
192	GO:0006464	cellular protein modification process
192	GO:0010467	gene expression
192	GO:0090304	nucleic acid metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
125	GO:0005829	cytosol
125	GO:0005634	nucleus
192	GO:0005829	cytosol
192	GO:0005654	nucleoplasm
270	GO:0005829	cytosol
270	GO:0070013	intracellular organelle lumen
270	GO:0005634	nucleus
359	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000209	protein polyubiquitination	IDA
GO:0006511	ubiquitin-dependent protein catabolic process	TAS
GO:0010390	histone monoubiquitination	IDA
GO:0016567	protein ubiquitination	TAS
GO:0031145	anaphase-promoting complex-dependent catabolic process	TAS
GO:0032020	ISG15-protein conjugation	IDA
GO:0033523	histone H2B ubiquitination	IDA
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	TAS
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	TAS
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	TAS

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000151	ubiquitin ligase complex	IDA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005829	cytosol	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 79 entries

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Interactor	Also a MoonDB EMF protein
ARI2_HUMAN	No
ARRD1_HUMAN	No
ASF1B_HUMAN	No
ATX1_HUMAN	Yes: P54253 (MoonDB)
BIRC7_HUMAN	No
BIRC8_HUMAN	No
BRCA1_HUMAN	No
CAPS2_HUMAN	No
CBWD3_HUMAN	No
CHFR_HUMAN	No

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Publications Associated

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PMID	Article Title
8576257	Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16428300	Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.
16641997	The DNA sequence, annotation and analysis of human chromosome 3.
17588522	E3-independent monoubiquitination of ubiquitin-binding proteins.
18845142	The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20061386	The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
21269460	Initial characterization of the human central proteome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 8 of 8 entries

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Domain Name	Domain ID	Source
SSF54495	SSF54495	SUPFAM
UBCc	cd00195	CDD
UBIQUITIN_CONJUGAT_1	PS00183	PROSITE
UBIQUITIN_CONJUGAT_2	PS50127	PROSITE
UBQ-conjugat_E2	IPR000608	InterPro
UBQ-conjugating_AS	IPR023313	InterPro
UBQ-conjugating_enzyme/RWD	IPR016135	InterPro
UQ_con	PF00179	Pfam

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