Protein: Q13064 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q13064 (Uniprot)	MKRN3_HUMAN	MKRN3	Probable E3 ubiquitin-protein ligase makorin-3	human	No

Protein Function

Uniprot: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	5, 384	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
5	GO:0034645	cellular macromolecule biosynthetic process
5	GO:0006464	cellular protein modification process
5	GO:0090304	nucleic acid metabolic process
5	GO:0034654	nucleobase-containing compound biosynthetic process
5	GO:0060255	regulation of macromolecule metabolic process
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
334	GO:0016070	RNA metabolic process
334	GO:0010467	gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
5	GO:0005829	cytosol
5	GO:0005634	nucleus
60	GO:0005634	nucleus
84	GO:0005634	nucleus
125	GO:0005829	cytosol
125	GO:0005634	nucleus
334	GO:0031981	nuclear lumen
354	GO:0005634	nucleus
384	GO:0005829	cytosol
384	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0016567	protein ubiquitination	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0030529	intracellular ribonucleoprotein complex	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433S_HUMAN	No
AAPK2_HUMAN	No
ADA2C_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)
ANR11_HUMAN	No
AP2A_HUMAN	No
APEX2_HUMAN	No
AQP1_HUMAN	No
ARI5A_HUMAN	No
ATL4_HUMAN	No

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Publications Associated

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PMID	Article Title
10196367	A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16959974	The consensus coding sequences of human breast and colorectal cancers.
19066619	A paternal deletion of MKRN3, MAGEL2 and NDN does not result in Prader-Willi syndrome.
23738509	Central precocious puberty caused by mutations in the imprinted gene MKRN3.
24438377	Central precocious puberty in a girl and early puberty in her brother caused by a novel mutation in the MKRN3 gene.
24628548	Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3.
25011910	MKRN3 mutations in familial central precocious puberty.
25316453	A novel MKRN3 missense mutation causing familial precocious puberty.

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OMIM Diseases Associated

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OMIM ID	Disease Name
615346	Precocious puberty, central 2

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Protein Domains Associated

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Domain Name	Domain ID	Source
G01614	G01614	PIR
Makorin_3	IPR026294	InterPro
MKRN1_C	IPR031644	InterPro
MKRN1_C	PF15815	Pfam
PTHR11224:SF38	PTHR11224:SF38	PANTHER
RING	SM00184	SMART
SSF90229	SSF90229	SUPFAM
zf-C3HC4	PF00097	Pfam
ZF_C3H1	PS50103	PROSITE
ZF_RING_1	PS00518	PROSITE

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