Protein: P68036

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P68036 (Uniprot) UB2L3_HUMAN UBE2L3 Ubiquitin-conjugating enzyme E2 L3 human No
Uniprot: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 5 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
5 GO:0034645 cellular macromolecule biosynthetic process
5 GO:0006464 cellular protein modification process
5 GO:0090304 nucleic acid metabolic process
5 GO:0034654 nucleobase-containing compound biosynthetic process
5 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
287 GO:0006464 cellular protein modification process
287 GO:0006355 regulation of transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
5 GO:0005829 cytosol
5 GO:0005634 nucleus
125 GO:0005829 cytosol
125 GO:0005634 nucleus
287 GO:0005829 cytosol
287 GO:0043232 intracellular non-membrane-bounded organelle
287 GO:0031981 nuclear lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000209 protein polyubiquitination IDA
GO:0006351 transcription, DNA-templated IEA
GO:0006355 regulation of transcription, DNA-templated IDA
GO:0006464 cellular protein modification process TAS
GO:0006511 ubiquitin-dependent protein catabolic process TAS
GO:0008283 cell proliferation IMP
GO:0016567 protein ubiquitination TAS
GO:0031398 positive regulation of protein ubiquitination IGI
GO:0044770 cell cycle phase transition IMP
GO:0051443 positive regulation of ubiquitin-protein transferase activity IGI
GO:0070979 protein K11-linked ubiquitination IDA
GO:0071383 cellular response to steroid hormone stimulus IMP
GO:0071385 cellular response to glucocorticoid stimulus IDA
GO:1903955 positive regulation of protein targeting to mitochondrion IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000151 ubiquitin ligase complex TAS
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
PMID Article Title
8144544 Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-'N-end rule' protein substrates.
8563171 A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3.
8576257 Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.
9693040 Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3.
10558980 Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
10591208 The DNA sequence of human chromosome 22.
10760570 Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7.
10888878 Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase.
10966114 Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
11237715 A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.
11278816 Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.
12612082 A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15367689 The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors.
15461802 A genome annotation-driven approach to cloning the human ORFeome.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16427630 The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis.
16709802 NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase.
17003263 UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation.
18946090 Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7.
19340006 The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
21269460 Initial characterization of the human central proteome.
21532592 UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.
22496338 A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
25632008 Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD