Protein: Q96LR5

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q96LR5 (Uniprot) UB2E2_HUMAN UBE2E2 Ubiquitin-conjugating enzyme E2 E2 human No
Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 270 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
204 GO:0044267 cellular protein metabolic process
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
331 GO:0016070 RNA metabolic process
331 GO:0006464 cellular protein modification process
331 GO:0010467 gene expression
331 GO:0060255 regulation of macromolecule metabolic process
331 GO:0019219 regulation of nucleobase-containing compound metabolic process
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
596 GO:0006464 cellular protein modification process
818 GO:0070647 protein modification by small protein conjugation or removal
818 GO:0006355 regulation of transcription, DNA-templated
818 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
134 GO:0005829 cytosol
134 GO:0005634 nucleus
204 GO:0005634 nucleus
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
331 GO:0005654 nucleoplasm
375 GO:0005829 cytosol
375 GO:0005634 nucleus
575 GO:0005654 nucleoplasm
596 GO:0005634 nucleus
818 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006974 cellular response to DNA damage stimulus IMP
GO:0032020 ISG15-protein conjugation IDA
GO:0070534 protein K63-linked ubiquitination IDA
GO:0070936 protein K48-linked ubiquitination IDA
GO:0070979 protein K11-linked ubiquitination IDA
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IGI
No results found.
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9371400 cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
20133869 ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22496338 A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD