Protein: Q96LR5 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q96LR5 (Uniprot)	UB2E2_HUMAN	UBE2E2	Ubiquitin-conjugating enzyme E2 E2	human	No

Protein Function

Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.

MoonDB Dissimilar Functions

Showing 1 to 1 of 1 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	270	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 29 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
53	GO:0006139	nucleobase-containing compound metabolic process
53	GO:0016567	protein ubiquitination
53	GO:0060255	regulation of macromolecule metabolic process
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
134	GO:0044267	cellular protein metabolic process
134	GO:0060255	regulation of macromolecule metabolic process
134	GO:0007165	signal transduction
204	GO:0044267	cellular protein metabolic process

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Cellular Components

Showing 1 to 10 of 16 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
125	GO:0005829	cytosol
125	GO:0005634	nucleus
134	GO:0005829	cytosol
134	GO:0005634	nucleus
204	GO:0005634	nucleus
270	GO:0005829	cytosol
270	GO:0070013	intracellular organelle lumen
270	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 6 of 6 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006974	cellular response to DNA damage stimulus	IMP
GO:0032020	ISG15-protein conjugation	IDA
GO:0070534	protein K63-linked ubiquitination	IDA
GO:0070936	protein K48-linked ubiquitination	IDA
GO:0070979	protein K11-linked ubiquitination	IDA
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IGI

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Cellular Components

No results found.

Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 62 entries

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Interactor	Also a MoonDB EMF protein
ARI2_HUMAN	No
ARRD3_HUMAN	No
BRCA1_HUMAN	No
CHFR_HUMAN	No
DAZP2_HUMAN	Yes: Q15038 (MoonDB)
DTX3_HUMAN	No
DTX3L_HUMAN	No
DZIP3_HUMAN	No
FAM9B_HUMAN	Yes: Q8IZU0 (MoonDB)
HERC5_HUMAN	No

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Publications Associated

Showing 1 to 10 of 12 entries

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PMID	Article Title
9371400	cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332	Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20061386	The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
20133869	ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.
21269460	Initial characterization of the human central proteome.
21406692	System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22496338	A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 8 of 8 entries

Search:

Domain Name	Domain ID	Source
SSF54495	SSF54495	SUPFAM
UBCc	cd00195	CDD
UBIQUITIN_CONJUGAT_1	PS00183	PROSITE
UBIQUITIN_CONJUGAT_2	PS50127	PROSITE
UBQ-conjugat_E2	IPR000608	InterPro
UBQ-conjugating_AS	IPR023313	InterPro
UBQ-conjugating_enzyme/RWD	IPR016135	InterPro
UQ_con	PF00179	Pfam

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