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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q9C035
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q9C035 (Uniprot)
TRIM5_HUMAN
TRIM5
Tripartite motif-containing protein 5
human
No
Protein Function
Uniprot:
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activ
ates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).
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MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0009056
catabolic process
125
GO:0009059
macromolecule biosynthetic process
5
,
384
6.37e-04
1.88e-40
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 18 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
5
GO:0034645
cellular macromolecule biosynthetic process
5
GO:0006464
cellular protein modification process
5
GO:0090304
nucleic acid metabolic process
5
GO:0034654
nucleobase-containing compound biosynthetic process
5
GO:0060255
regulation of macromolecule metabolic process
125
GO:0044248
cellular catabolic process
125
GO:0016567
protein ubiquitination
125
GO:0060255
regulation of macromolecule metabolic process
384
GO:0034645
cellular macromolecule biosynthetic process
384
GO:0006464
cellular protein modification process
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Cellular Components
Showing 1 to 7 of 7 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
5
GO:0005829
cytosol
5
GO:0005634
nucleus
125
GO:0005829
cytosol
125
GO:0005634
nucleus
384
GO:0005829
cytosol
384
GO:0031981
nuclear lumen
444
GO:0005634
nucleus
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 16 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0002218
activation of innate immune response
IDA
GO:0002221
pattern recognition receptor signaling pathway
IEA
GO:0006914
autophagy
IDA
GO:0016032
viral process
IEA
GO:0031664
regulation of lipopolysaccharide-mediated signaling pathway
IMP
GO:0032880
regulation of protein localization
IMP
GO:0043123
positive regulation of I-kappaB kinase/NF-kappaB signaling
IDA
GO:0043410
positive regulation of MAPK cascade
IMP
GO:0045087
innate immune response
IDA
GO:0046597
negative regulation of viral entry into host cell
IDA
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Cellular Components
Showing 1 to 5 of 5 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000932
P-body
IDA
GO:0005634
nucleus
IEA
GO:0005737
cytoplasm
IDA
GO:0005829
cytosol
TAS
GO:1990462
omegasome
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 35 entries
Search:
Interactor
Also a MoonDB EMF protein
ECHP_HUMAN
No
EWS_HUMAN
No
LZTR1_HUMAN
No
MAT1_HUMAN
Yes:
P51948 (MoonDB)
MKRN3_HUMAN
Yes:
Q13064 (MoonDB)
MPP7_HUMAN
No
MTURN_HUMAN
No
NTAQ1_HUMAN
Yes:
Q96HA8 (MoonDB)
OTU6A_HUMAN
No
OTUB2_HUMAN
No
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Publications Associated
Showing 1 to 10 of 32 entries
Search:
PMID
Article Title
11331580
The tripartite motif family identifies cell compartments.
12878161
BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15249690
Trim5alpha protein restricts both HIV-1 and murine leukemia virus.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16401428
High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans.
16474118
Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription.
16554811
Human chromosome 11 DNA sequence and analysis including novel gene identification.
16643975
Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1.
16809279
Removal of arginine 332 allows human TRIM5alpha to bind human immunodeficiency virus capsids and to restrict infection.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 24 entries
Search:
Domain Name
Domain ID
Source
B30.2/SPRY
IPR001870
InterPro
B302_SPRY
PS50188
PROSITE
BBOX
SM00336
SMART
BBOX
cd00021
CDD
BUTYPHLNCDUF
PR01407
PRINTS
Butyrophylin_SPRY
IPR003879
InterPro
ConA-like_dom_sf
IPR013320
InterPro
PTHR24103:SF426
PTHR24103:SF426
PANTHER
RING
SM00184
SMART
SPRY
PF00622
Pfam
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