Protein: P0CG47

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P0CG47 (Uniprot) UBB_HUMAN UBB Polyubiquitin-B human No
Uniprot: Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 243, 270 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
27 GO:0090304 nucleic acid metabolic process
27 GO:0060255 regulation of macromolecule metabolic process
29 GO:0060255 regulation of macromolecule metabolic process
29 GO:0007165 signal transduction
81 GO:0006139 nucleobase-containing compound metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
175 GO:0044267 cellular protein metabolic process
175 GO:0006139 nucleobase-containing compound metabolic process
175 GO:0010468 regulation of gene expression
214 GO:0044267 cellular protein metabolic process
214 GO:0006355 regulation of transcription, DNA-templated
222 GO:0006139 nucleobase-containing compound metabolic process
222 GO:0060255 regulation of macromolecule metabolic process
222 GO:0007165 signal transduction
239 GO:0006139 nucleobase-containing compound metabolic process
243 GO:0034645 cellular macromolecule biosynthetic process
243 GO:0044271 cellular nitrogen compound biosynthetic process
243 GO:0006464 cellular protein modification process
243 GO:0031325 positive regulation of cellular metabolic process
243 GO:0010604 positive regulation of macromolecule metabolic process
243 GO:0051173 positive regulation of nitrogen compound metabolic process
243 GO:0051252 regulation of RNA metabolic process
243 GO:0031326 regulation of cellular biosynthetic process
243 GO:0032268 regulation of cellular protein metabolic process
243 GO:0010468 regulation of gene expression
243 GO:0010556 regulation of macromolecule biosynthetic process
243 GO:0007165 signal transduction
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
376 GO:0044267 cellular protein metabolic process
376 GO:0007165 signal transduction
427 GO:0044267 cellular protein metabolic process
427 GO:0010467 gene expression
427 GO:0060255 regulation of macromolecule metabolic process
444 GO:0090304 nucleic acid metabolic process
444 GO:0060255 regulation of macromolecule metabolic process
444 GO:0019219 regulation of nucleobase-containing compound metabolic process
444 GO:0007165 signal transduction
618 GO:0016070 RNA metabolic process
618 GO:0044271 cellular nitrogen compound biosynthetic process
618 GO:0006464 cellular protein modification process
618 GO:0070887 cellular response to chemical stimulus
618 GO:0006955 immune response
618 GO:0035556 intracellular signal transduction
618 GO:0031328 positive regulation of cellular biosynthetic process
618 GO:0010628 positive regulation of gene expression
618 GO:0002684 positive regulation of immune system process
618 GO:0010557 positive regulation of macromolecule biosynthetic process
618 GO:0051173 positive regulation of nitrogen compound metabolic process
618 GO:0048584 positive regulation of response to stimulus
618 GO:0006508 proteolysis
618 GO:0042981 regulation of apoptotic process
618 GO:2000112 regulation of cellular macromolecule biosynthetic process
618 GO:0019219 regulation of nucleobase-containing compound metabolic process
656 GO:0016070 RNA metabolic process
656 GO:0034645 cellular macromolecule biosynthetic process
656 GO:0044271 cellular nitrogen compound biosynthetic process
656 GO:0010467 gene expression
656 GO:0060255 regulation of macromolecule metabolic process
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
713 GO:0090304 nucleic acid metabolic process
713 GO:0070647 protein modification by small protein conjugation or removal
713 GO:0007165 signal transduction
736 GO:0006139 nucleobase-containing compound metabolic process
736 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
27 GO:0031981 nuclear lumen
29 GO:0005634 nucleus
81 GO:0005829 cytosol
81 GO:0031981 nuclear lumen
125 GO:0005829 cytosol
125 GO:0005634 nucleus
134 GO:0005829 cytosol
134 GO:0005634 nucleus
175 GO:0005829 cytosol
175 GO:0005634 nucleus
214 GO:0044428 nuclear part
222 GO:0070013 intracellular organelle lumen
222 GO:0044428 nuclear part
239 GO:0043232 intracellular non-membrane-bounded organelle
239 GO:0031981 nuclear lumen
243 GO:0005829 cytosol
243 GO:0070013 intracellular organelle lumen
243 GO:0044428 nuclear part
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
317 GO:0005829 cytosol
376 GO:0005829 cytosol
376 GO:0005634 nucleus
427 GO:0070013 intracellular organelle lumen
444 GO:0005634 nucleus
466 GO:0005829 cytosol
618 GO:0005829 cytosol
618 GO:0044421 extracellular region part
618 GO:0043232 intracellular non-membrane-bounded organelle
618 GO:0005654 nucleoplasm
618 GO:0005886 plasma membrane
618 GO:0031982 vesicle
642 GO:0005634 nucleus
656 GO:0043232 intracellular non-membrane-bounded organelle
656 GO:0005634 nucleus
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
710 GO:0005829 cytosol
710 GO:0070013 intracellular organelle lumen
710 GO:0005634 nucleus
713 GO:0005829 cytosol
713 GO:0005634 nucleus
736 GO:0005829 cytosol
736 GO:0070013 intracellular organelle lumen
736 GO:0044428 nuclear part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000086 G2/M transition of mitotic cell cycle TAS
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS
GO:0000165 MAPK cascade TAS
GO:0000187 activation of MAPK activity TAS
GO:0000209 protein polyubiquitination TAS
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0005978 glycogen biosynthetic process TAS
GO:0006283 transcription-coupled nucleotide-excision repair TAS
GO:0006294 nucleotide-excision repair, preincision complex assembly TAS
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion TAS
GO:0006297 nucleotide-excision repair, DNA gap filling TAS
GO:0006457 protein folding TAS
GO:0006879 cellular iron ion homeostasis TAS
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
GO:0007179 transforming growth factor beta receptor signaling pathway TAS
GO:0007219 Notch signaling pathway TAS
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
GO:0007254 JNK cascade TAS
GO:0008543 fibroblast growth factor receptor signaling pathway TAS
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
GO:0016055 Wnt signaling pathway TAS
GO:0016197 endosomal transport TAS
GO:0016236 macroautophagy TAS
GO:0016567 protein ubiquitination TAS
GO:0016579 protein deubiquitination TAS
GO:0019058 viral life cycle TAS
GO:0019068 virion assembly TAS
GO:0019985 translesion synthesis TAS
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway TAS
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
GO:0031398 positive regulation of protein ubiquitination IDA
GO:0032479 regulation of type I interferon production TAS
GO:0032480 negative regulation of type I interferon production TAS
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0033683 nucleotide-excision repair, DNA incision TAS
GO:0034220 ion transmembrane transport TAS
GO:0035635 entry of bacterium into host cell TAS
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
GO:0036297 interstrand cross-link repair TAS
GO:0038061 NIK/NF-kappaB signaling TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038128 ERBB2 signaling pathway TAS
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
GO:0042276 error-prone translesion synthesis TAS
GO:0042769 DNA damage response, detection of DNA damage TAS
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS
GO:0043065 positive regulation of apoptotic process TAS
GO:0043066 negative regulation of apoptotic process TAS
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
GO:0043488 regulation of mRNA stability TAS
GO:0044267 cellular protein metabolic process TAS
GO:0045087 innate immune response TAS
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway TAS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter TAS
GO:0047497 mitochondrion transport along microtubule IDA
GO:0048812 neuron projection morphogenesis IMP
GO:0050852 T cell receptor signaling pathway TAS
GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
GO:0051403 stress-activated MAPK cascade TAS
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
GO:0051881 regulation of mitochondrial membrane potential IDA
GO:0055085 transmembrane transport TAS
GO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
GO:0060544 regulation of necroptotic process TAS
GO:0061024 membrane organization TAS
GO:0061136 regulation of proteasomal protein catabolic process IDA
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
GO:0070911 global genome nucleotide-excision repair TAS
GO:0070987 error-free translesion synthesis TAS
GO:0075733 intracellular transport of virus TAS
GO:0090090 negative regulation of canonical Wnt signaling pathway TAS
GO:0090263 positive regulation of canonical Wnt signaling pathway TAS
GO:1901214 regulation of neuron death IDA
GO:1901796 regulation of signal transduction by p53 class mediator TAS
GO:1902036 regulation of hematopoietic stem cell differentiation TAS
GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator IDA
GO:1902527 positive regulation of protein monoubiquitination IMP
GO:1904380 endoplasmic reticulum mannose trimming TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005615 extracellular space IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005739 mitochondrion IDA
GO:0005741 mitochondrial outer membrane TAS
GO:0005789 endoplasmic reticulum membrane TAS
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0010008 endosome membrane TAS
GO:0030666 endocytic vesicle membrane TAS
GO:0031982 vesicle IDA
GO:0043005 neuron projection IDA
GO:0043025 neuronal cell body IDA
GO:0043657 host cell IEA
GO:0044322 endoplasmic reticulum quality control compartment IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005615 extracellular space GO:0005654 nucleoplasm 1.00e-49 3.88e-77
GO:0005634 nucleus GO:0005789 endoplasmic reticulum membrane 1.61e-25 3.10e-56
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0010008 endosome membrane 1.38e-08 8.40e-30
GO:0005634 nucleus GO:0030666 endocytic vesicle membrane 1.59e-05 7.63e-18
GO:0005634 nucleus GO:0031982 vesicle 1.94e-54 3.27e-93
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0005789 endoplasmic reticulum membrane 1.09e-31 5.14e-59
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0010008 endosome membrane 1.55e-05 2.28e-48
GO:0005654 nucleoplasm GO:0031982 vesicle 4.01e-60 1.21e-165
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
GO:0005789 endoplasmic reticulum membrane GO:0005829 cytosol 4.27e-12 7.53e-04
Interactor Also a MoonDB EMF protein
TPM3_HUMAN No
DAZP2_HUMAN Yes: Q15038 (MoonDB)
UBQL2_HUMAN Yes: Q9UHD9 (MoonDB)
SDCB1_HUMAN Yes: O00560 (MoonDB)
UBQL1_HUMAN No
PLS4_HUMAN No
OPTN_HUMAN No
TS101_HUMAN Yes: Q99816 (MoonDB)
TIAR_HUMAN No
UBE3A_HUMAN Yes: Q05086 (MoonDB)
ZMAT2_HUMAN No
RS6_HUMAN No
UBP2_HUMAN Yes: O75604 (MoonDB)
PP2AA_HUMAN No
GGA1_HUMAN No
HSP7C_HUMAN Yes: P11142 (MoonDB)
PKHB2_HUMAN No
UBA1_HUMAN No
TPM2_HUMAN No
CACO2_HUMAN No
TRIM5_HUMAN Yes: Q9C035 (MoonDB)
VIME_HUMAN Yes: P08670 (MoonDB)
RABX5_HUMAN No
SSA27_HUMAN No
SARNP_HUMAN No
A4_HUMAN No
TAXB1_HUMAN Yes: Q86VP1 (MoonDB)
RD23B_HUMAN No
UBP7_HUMAN No
RNF11_HUMAN No
CDN1A_HUMAN Yes: P38936 (MoonDB)
DLGP4_HUMAN No
ACTB_HUMAN No
BRAP_HUMAN No
CCD50_HUMAN No
CDIP1_HUMAN No
DESI1_HUMAN No
DNLI4_HUMAN No
ECT2_HUMAN No
GGA3_HUMAN No
MTURN_HUMAN No
PABP1_HUMAN Yes: P11940 (MoonDB)
PGAM1_HUMAN No
PGK1_HUMAN Yes: P00558 (MoonDB)
PLSL_HUMAN No
POLI_HUMAN No
PP2AB_HUMAN No
PPM1G_HUMAN No
PSA4_HUMAN No
PTMA_HUMAN No
PURA2_HUMAN No
RAB35_HUMAN No
RENT1_HUMAN No
RL27A_HUMAN No
RL28_HUMAN No
RL30_HUMAN No
RL5_HUMAN No
RPAP3_HUMAN No
RRFM_HUMAN No
RS20_HUMAN No
RS8_HUMAN No
RS9_HUMAN No
SCOT1_HUMAN No
SERA_HUMAN No
SET_HUMAN No
SFPQ_HUMAN No
SODC_HUMAN No
STIP1_HUMAN No
STK4_HUMAN No
STMN1_HUMAN No
SYAC_HUMAN No
T2FA_HUMAN No
TBA1A_HUMAN No
TBA1B_HUMAN No
TBA1C_HUMAN No
TBA3C_HUMAN No
TBA4A_HUMAN No
TBA8_HUMAN No
TBCA_HUMAN No
TCAL3_HUMAN No
TCAL5_HUMAN No
TCAL6_HUMAN No
TE2IP_HUMAN No
THOC2_HUMAN No
THOC4_HUMAN No
TIF1B_HUMAN No
TKT_HUMAN No
TPM1_HUMAN No
TPM4_HUMAN No
UB2L3_HUMAN Yes: P68036 (MoonDB)
UBAC1_HUMAN No
UBE2S_HUMAN No
UBP14_HUMAN No
UBP46_HUMAN No
UCHL1_HUMAN No
UCHL3_HUMAN No
UT14A_HUMAN No
PMID Article Title
1128706 Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man.
3029682 The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily.
9422699 Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients.
14597671 Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain.
14745543 Lineage-specific homogenization of the polyubiquitin gene among human and great apes.
15466860 Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16443603 Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.
16543144 Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
18719106 Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
19754430 The emerging complexity of protein ubiquitination.
21762696 Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
24660806 Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.
24751536 PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
24784582 Ubiquitin is phosphorylated by PINK1 to activate parkin.
25527291 Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.
28525742 Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.
No results found.
Domain Name Domain ID Source
UQHUB A26437 PIR
Ubiquitin_dom IPR000626 InterPro
Ubiquitin_CS IPR019954 InterPro
Ubiquitin IPR019956 InterPro
Ubiquitin-like_domsf IPR029071 InterPro
ubiquitin PF00240 Pfam
UBIQUITIN PR00348 PRINTS
UBIQUITIN_1 PS00299 PROSITE
UBIQUITIN_2 PS50053 PROSITE
UBQ SM00213 SMART
SSF54236 SSF54236 SUPFAM