Protein: O00560

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O00560 (Uniprot) SDCB1_HUMAN SDCBP Syntenin-1 human No
Uniprot: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 52, 132, 354, 527 GO:0071705 nitrogen compound transport 624 1.03e-13 2.03e-86
GO:0044260 cellular macromolecule metabolic process 280, 340, 493, 530 GO:0071705 nitrogen compound transport 624 2.61e-10 9.86e-66
GO:0009056 catabolic process 359 GO:0009059 macromolecule biosynthetic process 401 6.37e-04 1.88e-40
GO:0009059 macromolecule biosynthetic process 401 GO:0071705 nitrogen compound transport 624 1.21e-06 4.82e-42
GO:0043170 macromolecule metabolic process 476 GO:0071705 nitrogen compound transport 624 9.47e-16 1.65e-67
GO:0071705 nitrogen compound transport 624 GO:0019219 regulation of nucleobase-containing compound metabolic process 70, 80 8.45e-12 1.56e-49
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
52 GO:0090304 nucleic acid metabolic process
70 GO:0051252 regulation of RNA metabolic process
70 GO:0010468 regulation of gene expression
70 GO:0006351 transcription, DNA-templated
80 GO:0051252 regulation of RNA metabolic process
80 GO:0010468 regulation of gene expression
96 GO:0016070 RNA metabolic process
96 GO:0010467 gene expression
132 GO:0090304 nucleic acid metabolic process
132 GO:0060255 regulation of macromolecule metabolic process
218 GO:0060255 regulation of macromolecule metabolic process
252 GO:0060255 regulation of macromolecule metabolic process
280 GO:0016070 RNA metabolic process
280 GO:0010467 gene expression
340 GO:0016070 RNA metabolic process
340 GO:0010467 gene expression
340 GO:0060255 regulation of macromolecule metabolic process
354 GO:0090304 nucleic acid metabolic process
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
401 GO:0034645 cellular macromolecule biosynthetic process
401 GO:0060255 regulation of macromolecule metabolic process
476 GO:0010467 gene expression
476 GO:0060255 regulation of macromolecule metabolic process
493 GO:0016070 RNA metabolic process
493 GO:0010467 gene expression
527 GO:0090304 nucleic acid metabolic process
527 GO:0060255 regulation of macromolecule metabolic process
530 GO:0016070 RNA metabolic process
530 GO:0060255 regulation of macromolecule metabolic process
603 GO:0060255 regulation of macromolecule metabolic process
624 GO:0042886 amide transport
624 GO:0022607 cellular component assembly
646 GO:0060255 regulation of macromolecule metabolic process
646 GO:0006351 transcription, DNA-templated
694 GO:0090304 nucleic acid metabolic process
694 GO:0060255 regulation of macromolecule metabolic process
699 GO:0022607 cellular component assembly
699 GO:0051649 establishment of localization in cell
699 GO:0071705 nitrogen compound transport
699 GO:0008104 protein localization
699 GO:0019538 protein metabolic process
702 GO:0007165 signal transduction
792 GO:0060255 regulation of macromolecule metabolic process
829 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
34 GO:0005634 nucleus
52 GO:0005829 cytosol
52 GO:0043232 intracellular non-membrane-bounded organelle
52 GO:0005654 nucleoplasm
70 GO:0005654 nucleoplasm
80 GO:0005634 nucleus
89 GO:0005634 nucleus
96 GO:0005654 nucleoplasm
117 GO:0005634 nucleus
132 GO:0005634 nucleus
143 GO:0005634 nucleus
176 GO:0016021 integral component of membrane
176 GO:0031090 organelle membrane
185 GO:0005829 cytosol
218 GO:0005634 nucleus
252 GO:0005634 nucleus
280 GO:0005634 nucleus
322 GO:0005634 nucleus
328 GO:0005829 cytosol
328 GO:0043232 intracellular non-membrane-bounded organelle
328 GO:0005654 nucleoplasm
332 GO:0005634 nucleus
340 GO:0005634 nucleus
354 GO:0005634 nucleus
359 GO:0005634 nucleus
375 GO:0005829 cytosol
375 GO:0005634 nucleus
396 GO:0012505 endomembrane system
401 GO:0005634 nucleus
402 GO:0005829 cytosol
422 GO:0005634 nucleus
438 GO:0005634 nucleus
476 GO:0005634 nucleus
493 GO:0031981 nuclear lumen
523 GO:0005829 cytosol
523 GO:0031982 vesicle
527 GO:0005634 nucleus
530 GO:0070013 intracellular organelle lumen
530 GO:0005634 nucleus
548 GO:0070013 intracellular organelle lumen
548 GO:0005634 nucleus
603 GO:0005634 nucleus
624 GO:0031090 organelle membrane
624 GO:0044459 plasma membrane part
624 GO:0031982 vesicle
630 GO:0005829 cytosol
630 GO:0043232 intracellular non-membrane-bounded organelle
630 GO:0005634 nucleus
642 GO:0005634 nucleus
646 GO:0005856 cytoskeleton
646 GO:0005634 nucleus
694 GO:0005634 nucleus
699 GO:0005829 cytosol
699 GO:0012505 endomembrane system
699 GO:0043232 intracellular non-membrane-bounded organelle
699 GO:0005634 nucleus
699 GO:0031982 vesicle
702 GO:0005829 cytosol
792 GO:0005829 cytosol
817 GO:0070013 intracellular organelle lumen
817 GO:0005634 nucleus
829 GO:0005829 cytosol
829 GO:0031982 vesicle
856 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002091 negative regulation of receptor internalization IMP
GO:0006612 protein targeting to membrane NAS
GO:0006930 substrate-dependent cell migration, cell extension NAS
GO:0007268 chemical synaptic transmission NAS
GO:0007346 regulation of mitotic cell cycle IMP
GO:0008284 positive regulation of cell proliferation IMP
GO:0010718 positive regulation of epithelial to mesenchymal transition IMP
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IMP
GO:0030036 actin cytoskeleton organization NAS
GO:0030307 positive regulation of cell growth IMP
GO:0030335 positive regulation of cell migration IMP
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IMP
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
GO:0035556 intracellular signal transduction NAS
GO:0042327 positive regulation of phosphorylation IDA
GO:0043312 neutrophil degranulation TAS
GO:0046330 positive regulation of JNK cascade IC
GO:0048013 ephrin receptor signaling pathway TAS
GO:1903543 positive regulation of exosomal secretion IMP
GO:1903553 positive regulation of extracellular exosome assembly IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005615 extracellular space IDA
GO:0005634 nucleus NAS
GO:0005654 nucleoplasm IDA
GO:0005737 cytoplasm IDA
GO:0005789 endoplasmic reticulum membrane IEA
GO:0005829 cytosol TAS
GO:0005856 cytoskeleton NAS
GO:0005886 plasma membrane IDA
GO:0005895 interleukin-5 receptor complex ISS
GO:0005912 adherens junction NAS
GO:0005925 focal adhesion IEA
GO:0016020 membrane NAS
GO:0031965 nuclear membrane IDA
GO:0035578 azurophil granule lumen TAS
GO:0042470 melanosome IEA
GO:0043231 intracellular membrane-bounded organelle IDA
GO:0045121 membrane raft IDA
GO:0070062 extracellular exosome IDA
GO:0072562 blood microparticle IDA
GO:1903561 extracellular vesicle IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005576 extracellular region GO:0005654 nucleoplasm 6.62e-72 7.68e-98
GO:0005576 extracellular region GO:0043231 intracellular membrane-bounded organelle 1.18e-59 7.46e-19
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005615 extracellular space GO:0005654 nucleoplasm 1.00e-49 3.88e-77
GO:0005615 extracellular space GO:0043231 intracellular membrane-bounded organelle 5.04e-30 2.07e-03
GO:0005634 nucleus GO:0005789 endoplasmic reticulum membrane 1.61e-25 3.10e-56
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005634 nucleus GO:1903561 extracellular vesicle 1.85e-13 4.00e-27
GO:0005654 nucleoplasm GO:0005789 endoplasmic reticulum membrane 1.09e-31 5.14e-59
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0016020 membrane 5.76e-255 1.32e-206
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
GO:0005654 nucleoplasm GO:1903561 extracellular vesicle 5.42e-21 1.29e-36
GO:0005789 endoplasmic reticulum membrane GO:0005829 cytosol 4.27e-12 7.53e-04
GO:0005789 endoplasmic reticulum membrane GO:0005856 cytoskeleton 1.07e-13 1.06e-67
GO:0005856 cytoskeleton GO:0043231 intracellular membrane-bounded organelle 3.21e-14 3.53e-300
GO:0005886 plasma membrane GO:0043231 intracellular membrane-bounded organelle 0.00e+00 3.79e-47
Interactor Also a MoonDB EMF protein
KRA59_HUMAN No
KR107_HUMAN No
FAM9A_HUMAN No
Q53GL6_HUMAN No
MEOX2_HUMAN Yes: P50222 (MoonDB)
HSF2B_HUMAN No
ZN343_HUMAN No
IHO1_HUMAN No
BEND7_HUMAN No
CRX_HUMAN No
TRI27_HUMAN Yes: P14373 (MoonDB)
ITF2_HUMAN No
REL_HUMAN No
KLH12_HUMAN No
MTUS2_HUMAN No
NT2NL_HUMAN No
NECA2_HUMAN No
PNMA1_HUMAN No
ZBT8A_HUMAN No
TRI54_HUMAN No
KTBL1_HUMAN No
ABI2_HUMAN Yes: Q9NYB9 (MoonDB)
A0A024RA76_HUMAN No
5NTC_HUMAN No
A0A0C4DFN3_HUMAN No
A2RRN7_HUMAN No
A5PKU2_HUMAN No
ABCB6_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
AFF4_HUMAN No
AN32B_HUMAN No
AN36B_HUMAN No
ANR33_HUMAN No
ANR40_HUMAN No
AR6P1_HUMAN No
ARFP2_HUMAN No
B1ALG1_HUMAN No
B2L15_HUMAN No
BRNP2_HUMAN No
C102B_HUMAN No
C2C2L_HUMAN No
CA109_HUMAN No
CABP5_HUMAN No
CACO2_HUMAN No
CALM1_HUMAN Yes: P0DP23 (MoonDB)
CAPS1_HUMAN No
CBR3_HUMAN No
CC106_HUMAN No
CDCP1_HUMAN No
CDD_HUMAN No
CDIPT_HUMAN No
CDN2D_HUMAN No
CE170_HUMAN No
CEP55_HUMAN No
CEP85_HUMAN No
CGBP1_HUMAN No
CHIC2_HUMAN No
CHM1A_HUMAN Yes: Q9HD42 (MoonDB)
CK057_HUMAN No
CK068_HUMAN No
CKLF5_HUMAN No
CLK2_HUMAN No
CLK3_HUMAN No
COX41_HUMAN No
CRYAA_HUMAN Yes: P02489 (MoonDB)
CT451_HUMAN No
CT453_HUMAN No
CT455_HUMAN No
CT45A_HUMAN No
CTBP2_HUMAN No
CTDS1_HUMAN No
CUTC_HUMAN No
CYHR1_HUMAN No
DCTD_HUMAN No
DCTP1_HUMAN No
DMC1_HUMAN No
DTBP1_HUMAN No
DX39B_HUMAN No
DYLT1_HUMAN No
DYN2_HUMAN Yes: P50570 (MoonDB)
EAF1_HUMAN No
EDAD_HUMAN No
EGLN1_HUMAN No
EIF1A_HUMAN No
ELAV1_HUMAN No
EMIL3_HUMAN No
ENOX1_HUMAN No
ERIC2_HUMAN No
EXOS4_HUMAN Yes: Q9NPD3 (MoonDB)
F118A_HUMAN No
F118B_HUMAN No
FAD1_HUMAN No
FADD_HUMAN No
FAM9B_HUMAN Yes: Q8IZU0 (MoonDB)
FHL3_HUMAN No
FHL5_HUMAN No
FOXP2_HUMAN No
FRIH_HUMAN No
FRIL_HUMAN No
G3ST1_HUMAN No
GET4_HUMAN Yes: Q7L5D6 (MoonDB)
GGPPS_HUMAN No
GKAP1_HUMAN No
GNMT_HUMAN No
GOT1B_HUMAN No
GPR37_HUMAN No
GPT11_HUMAN No
GRCR1_HUMAN No
GRIK1_HUMAN No
GRIK2_HUMAN No
GSG1_HUMAN No
HDAC7_HUMAN No
HEXI2_HUMAN No
HHAT_HUMAN No
HMBX1_HUMAN No
HMGB3_HUMAN No
HNRPC_HUMAN No
HOME3_HUMAN No
HOMEZ_HUMAN No
HPRT_HUMAN No
HSBP1_HUMAN No
HUS1_HUMAN No
HXA1_HUMAN No
HXA7_HUMAN No
IBP6_HUMAN No
ID3_HUMAN No
IF5A1_HUMAN No
IF5A2_HUMAN No
IFNL3_HUMAN No
IKZF1_HUMAN No
IL5RA_HUMAN No
IN80E_HUMAN No
K1C14_HUMAN No
KAT6B_HUMAN Yes: Q8WYB5 (MoonDB)
KCNH1_HUMAN No
KCNJ2_HUMAN No
KCNV1_HUMAN No
KCTD1_HUMAN No
KCTD6_HUMAN No
KCTD9_HUMAN No
KHDR2_HUMAN No
KLHL2_HUMAN No
KR103_HUMAN No
KRA15_HUMAN No
LDB2_HUMAN No
LDHB_HUMAN No
LDOC1_HUMAN No
LEG2_HUMAN No
LERL1_HUMAN No
LSM6_HUMAN No
LUR1L_HUMAN No
LZTL1_HUMAN No
MARE3_HUMAN No
MATN4_HUMAN No
MBD3_HUMAN No
MD2L1_HUMAN No
MED4_HUMAN No
MEOX1_HUMAN No
MERL_HUMAN No
MINY3_HUMAN No
MK09_HUMAN No
MKRN1_HUMAN No
MMTA2_HUMAN No
MOBP_HUMAN No
MOFA1_HUMAN No
MR1L1_HUMAN No
MTNB_HUMAN No
MYLIP_HUMAN No
MYOME_HUMAN No
MYPC2_HUMAN No
N4BP3_HUMAN No
NADK_HUMAN No
NAGK_HUMAN No
NC2A_HUMAN No
NECT1_HUMAN No
NECT3_HUMAN No
NO40_HUMAN No
ODAM_HUMAN No
ONCO_HUMAN No
OPTN_HUMAN No
OSTF1_HUMAN No
OTUB2_HUMAN No
P5CR3_HUMAN No
PCH2_HUMAN No
PCY1A_HUMAN No
PDC6I_HUMAN Yes: Q8WUM4 (MoonDB)
PDE9A_HUMAN No
PDLI4_HUMAN No
PFD5_HUMAN No
PHC2_HUMAN Yes: Q8IXK0 (MoonDB)
PHF11_HUMAN No
PHS_HUMAN Yes: P61457 (MoonDB)
PIHD2_HUMAN No
PNMA2_HUMAN No
PP6R2_HUMAN No
PPIP1_HUMAN No
PR38A_HUMAN No
PR40A_HUMAN Yes: O75400 (MoonDB)
PRR13_HUMAN No
PRS10_HUMAN No
PSB3_HUMAN No
PSME2_HUMAN No
PTPRJ_HUMAN No
PTPS_HUMAN No
PUF60_HUMAN No
RAB5A_HUMAN No
RBM39_HUMAN No
REEP6_HUMAN No
RIC8A_HUMAN No
RINI_HUMAN No
RIR2_HUMAN No
RL22_HUMAN No
RN186_HUMAN No
ROP1A_HUMAN No
RP9_HUMAN No
RPB11_HUMAN No
RPC10_HUMAN No
RPR1A_HUMAN No
RPRM_HUMAN No
RRS1_HUMAN No
RS26_HUMAN No
RTL8B_HUMAN No
RTN1_HUMAN No
RUN3A_HUMAN No
S100B_HUMAN No
SCG3_HUMAN No
SCLT1_HUMAN No
SCML1_HUMAN No
SDCG3_HUMAN No
SEPT1_HUMAN No
SEPT3_HUMAN No
SET_HUMAN No
SIAH1_HUMAN Yes: Q8IUQ4 (MoonDB)
SMCA2_HUMAN No
SNAB_HUMAN No
SNRPA_HUMAN No
SNX1_HUMAN Yes: Q13596 (MoonDB)
SP8_HUMAN No
SPERT_HUMAN No
SPXN3_HUMAN No
SR1IP_HUMAN No
SRCRL_HUMAN No
SRS11_HUMAN No
SRSF3_HUMAN No
SRSF7_HUMAN No
SSNA1_HUMAN No
ST1B1_HUMAN No
SWET1_HUMAN No
SYPL1_HUMAN No
T23O_HUMAN No
TBC3H_HUMAN No
TCF21_HUMAN No
TCP4_HUMAN No
TEKT1_HUMAN No
TFCP2_HUMAN No
TFIP8_HUMAN No
THG1_HUMAN No
TIFA_HUMAN No
TKFC_HUMAN No
TM239_HUMAN No
TMCO2_HUMAN No
TMM17_HUMAN Yes: Q86X19 (MoonDB)
TP8L3_HUMAN No
TRAF5_HUMAN No
TRI32_HUMAN No
TRI38_HUMAN No
TRIM1_HUMAN Yes: Q9UJV3 (MoonDB)
TSN_HUMAN No
UB2R1_HUMAN No
UB2R2_HUMAN No
UBB_HUMAN Yes: P0CG47 (MoonDB)
UBE2A_HUMAN No
UBE2K_HUMAN Yes: P61086 (MoonDB)
ULK1_HUMAN No
WASC3_HUMAN No
WASL_HUMAN No
WDR91_HUMAN No
YIF1A_HUMAN No
ZBT14_HUMAN No
ZCH10_HUMAN No
ZEP1_HUMAN Yes: P15822 (MoonDB)
ZMY12_HUMAN No
ZN485_HUMAN No
ZN660_HUMAN No
ZN768_HUMAN No
ZRAN1_HUMAN No
ZSC23_HUMAN No
PMID Article Title
9391086 Syntenin, a PDZ protein that binds syndecan cytoplasmic domains.
9511750 Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene.
9883737 PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.
10230395 A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.
10770943 Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin.
11152476 The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity.
11179419 Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments.
11432873 Schwannomin isoform-1 interacts with syntenin via PDZ domains.
11498591 Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein.
12643545 Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
12679023 PDZ tandem of human syntenin: crystal structure and functional properties.
12842047 Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15081807 The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16421571 DNA sequence and analysis of human chromosome 8.
16533050 The binding of the PDZ tandem of syntenin to target proteins.
17081065 Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
21269460 Initial characterization of the human central proteome.
22660413 Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25219541 Targeting tumor invasion: the roles of MDA-9/Syntenin.
25893292 Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization.
26032692 Syntenin and syndecan in the biogenesis of exosomes.
26291527 MDA-9/syntenin control.
26539120 Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells.
27386966 Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.
No results found.
Domain Name Domain ID Source
PDZ IPR001478 InterPro
SDCBP IPR030528 InterPro
PDZ_sf IPR036034 InterPro
JC6537 JC6537 PIR
PDZ PF00595 Pfam
PDZ PS50106 PROSITE
PTHR12345:SF10 PTHR12345:SF10 PANTHER
PDZ SM00228 SMART
SSF50156 SSF50156 SUPFAM