Protein: O00560 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O00560 (Uniprot)	SDCB1_HUMAN	SDCBP	Syntenin-1	human	No

Protein Function

Uniprot: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition more..

MoonDB Dissimilar Functions

Showing 1 to 6 of 6 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	52, 132, 354, 527	GO:0071705	nitrogen compound transport	624	1.03e-13	2.03e-86
GO:0009056	catabolic process	359	GO:0009059	macromolecule biosynthetic process	401	6.37e-04	1.88e-40
GO:0009059	macromolecule biosynthetic process	401	GO:0071705	nitrogen compound transport	624	1.21e-06	4.82e-42
GO:0043170	macromolecule metabolic process	476	GO:0071705	nitrogen compound transport	624	9.47e-16	1.65e-67
GO:0044260	cellular macromolecule metabolic process	280, 340, 493, 530	GO:0071705	nitrogen compound transport	624	2.61e-10	9.86e-66
GO:0071705	nitrogen compound transport	624	GO:0019219	regulation of nucleobase-containing compound metabolic process	70, 80	8.45e-12	1.56e-49

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
52	GO:0090304	nucleic acid metabolic process
70	GO:0051252	regulation of RNA metabolic process
70	GO:0010468	regulation of gene expression
70	GO:0006351	transcription, DNA-templated
80	GO:0051252	regulation of RNA metabolic process
80	GO:0010468	regulation of gene expression
96	GO:0016070	RNA metabolic process
96	GO:0010467	gene expression
132	GO:0090304	nucleic acid metabolic process
132	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
34	GO:0005634	nucleus
52	GO:0005829	cytosol
52	GO:0043232	intracellular non-membrane-bounded organelle
52	GO:0005654	nucleoplasm
70	GO:0005654	nucleoplasm
80	GO:0005634	nucleus
89	GO:0005634	nucleus
96	GO:0005654	nucleoplasm
117	GO:0005634	nucleus
132	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002091	negative regulation of receptor internalization	IMP
GO:0006612	protein targeting to membrane	NAS
GO:0006930	substrate-dependent cell migration, cell extension	NAS
GO:0007268	chemical synaptic transmission	NAS
GO:0007346	regulation of mitotic cell cycle	IMP
GO:0008284	positive regulation of cell proliferation	IMP
GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IMP
GO:0030036	actin cytoskeleton organization	NAS
GO:0030307	positive regulation of cell growth	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IDA
GO:0005634	nucleus	NAS
GO:0005654	nucleoplasm	IDA
GO:0005737	cytoplasm	IDA
GO:0005789	endoplasmic reticulum membrane	IEA
GO:0005829	cytosol	TAS
GO:0005856	cytoskeleton	NAS
GO:0005886	plasma membrane	IDA
GO:0005895	interleukin-5 receptor complex	ISS

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005576	extracellular region	GO:0005654	nucleoplasm	6.62e-72	7.68e-98
GO:0005576	extracellular region	GO:0043231	intracellular membrane-bounded organelle	1.18e-59	7.46e-19
GO:0005615	extracellular space	GO:0005634	nucleus	6.26e-54	1.10e-77
GO:0005615	extracellular space	GO:0005654	nucleoplasm	1.00e-49	3.88e-77
GO:0005615	extracellular space	GO:0043231	intracellular membrane-bounded organelle	5.04e-30	2.07e-03
GO:0005634	nucleus	GO:0005789	endoplasmic reticulum membrane	1.61e-25	3.10e-56
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
5NTC_HUMAN	No
A0A024RA76_HUMAN	No
A0A0C4DFN3_HUMAN	No
A2RRN7_HUMAN	No
A5PKU2_HUMAN	No
ABCB6_HUMAN	No
ABI2_HUMAN	Yes: Q9NYB9 (MoonDB)
AES_HUMAN	Yes: Q08117 (MoonDB)
AFF4_HUMAN	No
AN32B_HUMAN	No

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Publications Associated

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PMID	Article Title
9391086	Syntenin, a PDZ protein that binds syndecan cytoplasmic domains.
9511750	Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene.
9883737	PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.
10230395	A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.
10770943	Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin.
11152476	The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity.
11179419	Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments.
11432873	Schwannomin isoform-1 interacts with syntenin via PDZ domains.
11498591	Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein.
12643545	Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
JC6537	JC6537	PIR
PDZ	IPR001478	InterPro
PDZ	PF00595	Pfam
PDZ	PS50106	PROSITE
PDZ	SM00228	SMART
PDZ_sf	IPR036034	InterPro
PTHR12345:SF10	PTHR12345:SF10	PANTHER
SDCBP	IPR030528	InterPro
SSF50156	SSF50156	SUPFAM

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