Protein: O75400

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O75400 (Uniprot) PR40A_HUMAN PRPF40A Pre-mRNA-processing factor 40 homolog A human No
Uniprot: Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 294, 353 GO:0019538 protein metabolic process 56, 413 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
51 GO:0060255 regulation of macromolecule metabolic process
56 GO:0044267 cellular protein metabolic process
56 GO:0060255 regulation of macromolecule metabolic process
96 GO:0016070 RNA metabolic process
96 GO:0010467 gene expression
167 GO:0016070 RNA metabolic process
167 GO:0010467 gene expression
167 GO:0060255 regulation of macromolecule metabolic process
199 GO:0006464 cellular protein modification process
199 GO:0060255 regulation of macromolecule metabolic process
199 GO:0007165 signal transduction
294 GO:0000398 mRNA splicing, via spliceosome
353 GO:0000398 mRNA splicing, via spliceosome
384 GO:0034645 cellular macromolecule biosynthetic process
384 GO:0006464 cellular protein modification process
384 GO:0090304 nucleic acid metabolic process
384 GO:0031326 regulation of cellular biosynthetic process
384 GO:0060255 regulation of macromolecule metabolic process
384 GO:0007165 signal transduction
413 GO:0044267 cellular protein metabolic process
413 GO:0031326 regulation of cellular biosynthetic process
413 GO:0010468 regulation of gene expression
413 GO:0010556 regulation of macromolecule biosynthetic process
413 GO:0007165 signal transduction
413 GO:0006351 transcription, DNA-templated
493 GO:0016070 RNA metabolic process
493 GO:0010467 gene expression
573 GO:0006464 cellular protein modification process
573 GO:0006139 nucleobase-containing compound metabolic process
573 GO:0060255 regulation of macromolecule metabolic process
573 GO:0007165 signal transduction
700 GO:0019538 protein metabolic process
700 GO:0060255 regulation of macromolecule metabolic process
720 GO:0006464 cellular protein modification process
720 GO:0071310 cellular response to organic substance
720 GO:0006355 regulation of transcription, DNA-templated
720 GO:0006366 transcription from RNA polymerase II promoter
758 GO:0016070 RNA metabolic process
758 GO:0034645 cellular macromolecule biosynthetic process
758 GO:0044271 cellular nitrogen compound biosynthetic process
758 GO:0044267 cellular protein metabolic process
758 GO:0009893 positive regulation of metabolic process
758 GO:0010468 regulation of gene expression
758 GO:0019219 regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
51 GO:0005634 nucleus
56 GO:0005829 cytosol
91 GO:0005576 extracellular region
96 GO:0005654 nucleoplasm
167 GO:0005654 nucleoplasm
199 GO:0012505 endomembrane system
199 GO:0005576 extracellular region
199 GO:0070013 intracellular organelle lumen
294 GO:0030529 intracellular ribonucleoprotein complex
294 GO:0005654 nucleoplasm
353 GO:0005654 nucleoplasm
384 GO:0005829 cytosol
384 GO:0031981 nuclear lumen
413 GO:0005654 nucleoplasm
493 GO:0031981 nuclear lumen
573 GO:0005829 cytosol
573 GO:0012505 endomembrane system
573 GO:0070013 intracellular organelle lumen
573 GO:0044428 nuclear part
573 GO:0031982 vesicle
700 GO:0070013 intracellular organelle lumen
700 GO:0005634 nucleus
700 GO:0031982 vesicle
709 GO:0044421 extracellular region part
720 GO:0005829 cytosol
720 GO:0005654 nucleoplasm
758 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000398 mRNA splicing, via spliceosome TAS
GO:0007010 cytoskeleton organization IMP
GO:0007049 cell cycle IEA
GO:0008360 regulation of cell shape IMP
GO:0016477 cell migration IMP
GO:0032465 regulation of cytokinesis IMP
GO:0051301 cell division IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005654 nucleoplasm TAS
GO:0005685 U1 snRNP IBA
GO:0005829 cytosol IDA
GO:0016020 membrane IDA
GO:0016363 nuclear matrix IDA
GO:0016607 nuclear speck IDA
GO:0071004 U2-type prespliceosome IBA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005654 nucleoplasm GO:0016020 membrane 5.76e-255 1.32e-206
GO:0016020 membrane GO:0016607 nuclear speck 9.49e-26 4.88e-97
Interactor Also a MoonDB EMF protein
DDT4L_HUMAN Yes: Q96D03 (MoonDB)
PICK1_HUMAN Yes: Q9NRD5 (MoonDB)
BEND7_HUMAN No
PROP1_HUMAN No
UBQL2_HUMAN Yes: Q9UHD9 (MoonDB)
SDCB1_HUMAN Yes: O00560 (MoonDB)
RBM39_HUMAN No
SR1IP_HUMAN No
SDCB2_HUMAN Yes: Q9H190 (MoonDB)
UBQL1_HUMAN No
CSK21_HUMAN Yes: P68400 (MoonDB)
HSPB1_HUMAN Yes: P04792 (MoonDB)
HD_HUMAN Yes: P42858 (MoonDB)
HNRL1_HUMAN No
BAG6_HUMAN No
ZFHX3_HUMAN No
RU17_HUMAN Yes: P08621 (MoonDB)
SNIP1_HUMAN Yes: Q8TAD8 (MoonDB)
RBMX2_HUMAN No
CD045_HUMAN No
CAP2_HUMAN No
UBQL4_HUMAN No
UBC9_HUMAN Yes: P63279 (MoonDB)
UBE2K_HUMAN Yes: P61086 (MoonDB)
F10C1_HUMAN No
U2AF1_HUMAN No
MECP2_HUMAN No
SF3B2_HUMAN No
PIAS1_HUMAN No
SMAD4_HUMAN No
ZHX1_HUMAN No
SF01_HUMAN Yes: Q15637 (MoonDB)
CHD3_HUMAN Yes: Q12873 (MoonDB)
LTBP3_HUMAN No
SPB9_HUMAN No
ZCH10_HUMAN No
PPIG_HUMAN No
ASXL2_HUMAN No
BIG2_HUMAN No
BRD4_HUMAN No
CCNL1_HUMAN No
CDK12_HUMAN No
CDK13_HUMAN No
CHERP_HUMAN Yes: Q8IWX8 (MoonDB)
CT451_HUMAN No
DAAM1_HUMAN No
DHX8_HUMAN No
DIAP1_HUMAN No
DZI1L_HUMAN No
DZIP1_HUMAN No
FMNL1_HUMAN No
FMNL2_HUMAN No
FMNL3_HUMAN No
FNBP4_HUMAN No
HIPK1_HUMAN No
IL1AP_HUMAN No
KAP0_HUMAN No
LARP7_HUMAN No
MLP3A_HUMAN No
NKAP_HUMAN No
PCBP2_HUMAN No
PDCD7_HUMAN No
PECA1_HUMAN No
PFKAL_HUMAN No
PIAS3_HUMAN No
PIAS4_HUMAN No
PSG5_HUMAN No
PTPRF_HUMAN No
RLF_HUMAN No
SDK1_HUMAN No
SF3A1_HUMAN No
SON_HUMAN No
SR140_HUMAN No
SREK1_HUMAN No
STIM2_HUMAN No
TCAL9_HUMAN No
UBR4_HUMAN No
VINC_HUMAN No
ZCHC8_HUMAN No
ZN451_HUMAN No
PMID Article Title
9700202 Huntingtin interacts with a family of WW domain proteins.
10508479 Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
11042152 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
12381297 The structure of an FF domain from human HYPA/FBP11.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
16391387 Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18220336 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
18669648 A quantitative atlas of mitotic phosphorylation.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21834987 Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
WW_dom IPR001202 InterPro
FF_domain IPR002713 InterPro
WW_dom_sf IPR036020 InterPro
FF_domain_sf IPR036517 InterPro
WW PF00397 Pfam
FF PF01846 Pfam
WW_DOMAIN_1 PS01159 PROSITE
WW_DOMAIN_2 PS50020 PROSITE
FF PS51676 PROSITE
FF SM00441 SMART
WW SM00456 SMART
SSF51045 SSF51045 SUPFAM
SSF81698 SSF81698 SUPFAM
WW cd00201 CDD