Protein: Q8WYB5 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8WYB5 (Uniprot)	KAT6B_HUMAN	KAT6B	Histone acetyltransferase KAT6B	human	No

Protein Function

Uniprot: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0036211	protein modification process	201	GO:0006396	RNA processing	681	5.60e-03	3.14e-16

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
44	GO:0010467	gene expression
44	GO:0031324	negative regulation of cellular metabolic process
44	GO:0009889	regulation of biosynthetic process
44	GO:0060255	regulation of macromolecule metabolic process
191	GO:0006355	regulation of transcription, DNA-templated
201	GO:0006464	cellular protein modification process
201	GO:0031325	positive regulation of cellular metabolic process
201	GO:0010604	positive regulation of macromolecule metabolic process
201	GO:0051173	positive regulation of nitrogen compound metabolic process
201	GO:0010646	regulation of cell communication

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
44	GO:0005829	cytosol
44	GO:0005634	nucleus
72	GO:0016021	integral component of membrane
191	GO:0031981	nuclear lumen
201	GO:0005829	cytosol
201	GO:0005654	nucleoplasm
252	GO:0005634	nucleus
463	GO:0005654	nucleoplasm
654	GO:0005654	nucleoplasm
681	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006334	nucleosome assembly	NAS
GO:0006351	transcription, DNA-templated	IEA
GO:0006355	regulation of transcription, DNA-templated	NAS
GO:0016573	histone acetylation	IDA
GO:0043966	histone H3 acetylation	IDA
GO:0045892	negative regulation of transcription, DNA-templated	IDA
GO:0045893	positive regulation of transcription, DNA-templated	IDA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA
GO:1990830	cellular response to leukemia inhibitory factor	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000786	nucleosome	NAS
GO:0005634	nucleus	TAS
GO:0005654	nucleoplasm	TAS
GO:0070776	MOZ/MORF histone acetyltransferase complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ARI5A_HUMAN	No
ARL4C_HUMAN	No
ARY2_HUMAN	No
ATN1_HUMAN	No
AVPI1_HUMAN	No
BMR1A_HUMAN	No
CASP9_HUMAN	No
CCL2_HUMAN	No
CDC42_HUMAN	Yes: P60953 (MoonDB)
CDKA2_HUMAN	No

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Publications Associated

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PMID	Article Title
9205841	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
10497217	Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein.
11157802	Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13).
11965546	MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.
12168954	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16387653	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
16959974	The consensus coding sequences of human breast and colorectal cancers.
18794358	Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.
19608861	Lysine acetylation targets protein complexes and co-regulates major cellular functions.

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OMIM Diseases Associated

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OMIM ID	Disease Name
603736	Ohdo syndrome, SBBYS variant
606170	Genitopatellar syndrome

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Protein Domains Associated

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Domain Name	Domain ID	Source
Acyl_CoA_acyltransferase	IPR016181	InterPro
H15	PS51504	PROSITE
H15	SM00526	SMART
HAT_MYST-type	IPR002717	InterPro
Histone_H1/H5_H15	IPR005818	InterPro
MOZ_SAS	PF01853	Pfam
MYST_HAT	PS51726	PROSITE
PHD	PF00628	Pfam
PHD	SM00249	SMART
SSF46785	SSF46785	SUPFAM

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