Protein: Q8WYB5

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8WYB5 (Uniprot) KAT6B_HUMAN KAT6B Histone acetyltransferase KAT6B human No
Uniprot: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 201 GO:0006396 RNA processing 681 5.60e-03 3.14e-16
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
44 GO:0010467 gene expression
44 GO:0031324 negative regulation of cellular metabolic process
44 GO:0009889 regulation of biosynthetic process
44 GO:0060255 regulation of macromolecule metabolic process
191 GO:0006355 regulation of transcription, DNA-templated
201 GO:0006464 cellular protein modification process
201 GO:0031325 positive regulation of cellular metabolic process
201 GO:0010604 positive regulation of macromolecule metabolic process
201 GO:0051173 positive regulation of nitrogen compound metabolic process
201 GO:0010646 regulation of cell communication
201 GO:0023051 regulation of signaling
201 GO:0006355 regulation of transcription, DNA-templated
201 GO:0007165 signal transduction
252 GO:0060255 regulation of macromolecule metabolic process
463 GO:0090304 nucleic acid metabolic process
463 GO:0060255 regulation of macromolecule metabolic process
654 GO:0010467 gene expression
654 GO:0019538 protein metabolic process
654 GO:0060255 regulation of macromolecule metabolic process
681 GO:0008380 RNA splicing
681 GO:0006397 mRNA processing
681 GO:0051252 regulation of RNA metabolic process
681 GO:0010468 regulation of gene expression
753 GO:0044267 cellular protein metabolic process
753 GO:0034654 nucleobase-containing compound biosynthetic process
753 GO:0031325 positive regulation of cellular metabolic process
753 GO:0010604 positive regulation of macromolecule metabolic process
753 GO:0051173 positive regulation of nitrogen compound metabolic process
753 GO:0031326 regulation of cellular biosynthetic process
753 GO:0019219 regulation of nucleobase-containing compound metabolic process
753 GO:0009966 regulation of signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
44 GO:0005829 cytosol
44 GO:0005634 nucleus
72 GO:0016021 integral component of membrane
191 GO:0031981 nuclear lumen
201 GO:0005829 cytosol
201 GO:0005654 nucleoplasm
252 GO:0005634 nucleus
463 GO:0005654 nucleoplasm
654 GO:0005654 nucleoplasm
681 GO:0005654 nucleoplasm
753 GO:0005634 nucleus
800 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006334 nucleosome assembly NAS
GO:0006351 transcription, DNA-templated IEA
GO:0006355 regulation of transcription, DNA-templated NAS
GO:0016573 histone acetylation IDA
GO:0043966 histone H3 acetylation IDA
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA
GO:1990830 cellular response to leukemia inhibitory factor IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000786 nucleosome NAS
GO:0005634 nucleus TAS
GO:0005654 nucleoplasm TAS
GO:0070776 MOZ/MORF histone acetyltransferase complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9205841 Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
10497217 Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein.
11157802 Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13).
11965546 MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.
12168954 Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16387653 ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
16959974 The consensus coding sequences of human breast and colorectal cancers.
18794358 Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
22077973 Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome.
22265014 Mutations in KAT6B, encoding a histone acetyltransferase, cause Genitopatellar syndrome.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
25755297 System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
25772364 SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
OMIM ID Disease Name
603736 Ohdo syndrome, SBBYS variant
606170 Genitopatellar syndrome
Domain Name Domain ID Source
Znf_PHD IPR001965 InterPro
HAT_MYST-type IPR002717 InterPro
Histone_H1/H5_H15 IPR005818 InterPro
Znf_FYVE_PHD IPR011011 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
Acyl_CoA_acyltransferase IPR016181 InterPro
Znf_PHD-finger IPR019787 InterPro
WH-like_DNA-bd_sf IPR036388 InterPro
WH_DNA-bd_sf IPR036390 InterPro
PHD PF00628 Pfam
MOZ_SAS PF01853 Pfam
ZF_PHD_1 PS01359 PROSITE
ZF_PHD_2 PS50016 PROSITE
H15 PS51504 PROSITE
MYST_HAT PS51726 PROSITE
PHD SM00249 SMART
H15 SM00526 SMART
SSF46785 SSF46785 SUPFAM
SSF55729 SSF55729 SUPFAM
SSF57903 SSF57903 SUPFAM