Protein: Q7L5D6

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q7L5D6 (Uniprot) GET4_HUMAN GET4 Golgi to ER traffic protein 4 homolog human No
Uniprot: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 1 GO:0034641 cellular nitrogen compound metabolic process 267 4.22e-144 6.90e-18
Module ID (MoonGO) GO ID (BP) GO Name
1 GO:0035556 intracellular signal transduction
1 GO:0032268 regulation of cellular protein metabolic process
1 GO:0043067 regulation of programmed cell death
1 GO:0009966 regulation of signal transduction
267 GO:0044271 cellular nitrogen compound biosynthetic process
267 GO:0010467 gene expression
267 GO:0009059 macromolecule biosynthetic process
267 GO:0090304 nucleic acid metabolic process
267 GO:0019538 protein metabolic process
267 GO:0060255 regulation of macromolecule metabolic process
676 GO:0016070 RNA metabolic process
676 GO:0044267 cellular protein metabolic process
676 GO:0010467 gene expression
676 GO:0060255 regulation of macromolecule metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
1 GO:0005829 cytosol
1 GO:0005634 nucleus
267 GO:0005829 cytosol
267 GO:0070013 intracellular organelle lumen
267 GO:0005634 nucleus
676 GO:0070013 intracellular organelle lumen
676 GO:0044428 nuclear part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006810 transport IEA
GO:0051220 cytoplasmic sequestering of protein IMP
GO:0071816 tail-anchored membrane protein insertion into ER membrane IMP
GO:1904378 maintenance of unfolded protein involved in ERAD pathway IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005654 nucleoplasm IDA
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol IDA
GO:0071818 BAT3 complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
10810093 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.
12690205 Human chromosome 7: DNA sequence and biology.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17974005 The full-ORF clone resource of the German cDNA consortium.
18249086 Genomic, evolutionary, and expression analyses of cee, an ancient gene involved in normal growth and development.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20676083 A ribosome-associating factor chaperones tail-anchored membrane proteins.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21636303 A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.
21743475 Protein targeting and degradation are coupled for elimination of mislocalized proteins.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
28104892 Mechanistic basis for a molecular triage reaction.
No results found.
Domain Name Domain ID Source
UPF0363 IPR007317 InterPro
DUF410 PF04190 Pfam
T42648 T42648 PIR