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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q7L5D6
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q7L5D6 (Uniprot)
GET4_HUMAN
GET4
Golgi to ER traffic protein 4 homolog
human
No
Protein Function
Uniprot:
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo d
egradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).
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MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0007165
signal transduction
1
GO:0034641
cellular nitrogen compound metabolic process
267
4.22e-144
6.90e-18
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 14 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
1
GO:0035556
intracellular signal transduction
1
GO:0032268
regulation of cellular protein metabolic process
1
GO:0043067
regulation of programmed cell death
1
GO:0009966
regulation of signal transduction
267
GO:0044271
cellular nitrogen compound biosynthetic process
267
GO:0010467
gene expression
267
GO:0009059
macromolecule biosynthetic process
267
GO:0090304
nucleic acid metabolic process
267
GO:0019538
protein metabolic process
267
GO:0060255
regulation of macromolecule metabolic process
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Cellular Components
Showing 1 to 7 of 7 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
1
GO:0005829
cytosol
1
GO:0005634
nucleus
267
GO:0005829
cytosol
267
GO:0070013
intracellular organelle lumen
267
GO:0005634
nucleus
676
GO:0070013
intracellular organelle lumen
676
GO:0044428
nuclear part
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Protein GO Annotations
Biological Processes
Showing 1 to 4 of 4 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006810
transport
IEA
GO:0051220
cytoplasmic sequestering of protein
IMP
GO:0071816
tail-anchored membrane protein insertion into ER membrane
IMP
GO:1904378
maintenance of unfolded protein involved in ERAD pathway
IMP
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Cellular Components
Showing 1 to 5 of 5 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005654
nucleoplasm
IDA
GO:0005730
nucleolus
IDA
GO:0005737
cytoplasm
IDA
GO:0005829
cytosol
IDA
GO:0071818
BAT3 complex
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 33 entries
Search:
Interactor
Also a MoonDB EMF protein
AAKB2_HUMAN
No
AKT1_HUMAN
No
ASNA_HUMAN
No
ATP5H_HUMAN
No
BAG6_HUMAN
No
CA109_HUMAN
No
CDN1A_HUMAN
Yes:
P38936 (MoonDB)
CE126_HUMAN
No
CPNS1_HUMAN
No
DUS21_HUMAN
No
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Publications Associated
Showing 1 to 10 of 16 entries
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PMID
Article Title
10810093
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.
12690205
Human chromosome 7: DNA sequence and biology.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17974005
The full-ORF clone resource of the German cDNA consortium.
18249086
Genomic, evolutionary, and expression analyses of cee, an ancient gene involved in normal growth and development.
19413330
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20676083
A ribosome-associating factor chaperones tail-anchored membrane proteins.
21269460
Initial characterization of the human central proteome.
21406692
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 4 of 4 entries
Search:
Domain Name
Domain ID
Source
DUF410
PF04190
Pfam
PTHR12875
PTHR12875
PANTHER
T42648
T42648
PIR
UPF0363
IPR007317
InterPro
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