Protein: Q13596

Uniprot: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0033036 macromolecule localization 517 GO:0006139 nucleobase-containing compound metabolic process 527 4.58e-19 9.70e-72
Module ID (MoonGO) GO ID (BP) GO Name
79 GO:0007165 signal transduction
517 GO:0008104 protein localization
517 GO:0019538 protein metabolic process
521 GO:0060255 regulation of macromolecule metabolic process
527 GO:0090304 nucleic acid metabolic process
527 GO:0060255 regulation of macromolecule metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
34 GO:0005634 nucleus
79 GO:0005634 nucleus
176 GO:0016021 integral component of membrane
176 GO:0031090 organelle membrane
350 GO:0012505 endomembrane system
350 GO:0031224 intrinsic component of membrane
517 GO:0005829 cytosol
517 GO:0012505 endomembrane system
517 GO:0031982 vesicle
521 GO:0070013 intracellular organelle lumen
521 GO:0005634 nucleus
527 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006886 intracellular protein transport IMP
GO:0016050 vesicle organization IBA
GO:0031623 receptor internalization IMP
GO:0034498 early endosome to Golgi transport IMP
GO:0042147 retrograde transport, endosome to Golgi NAS
GO:0045732 positive regulation of protein catabolic process IEA
GO:0072673 lamellipodium morphogenesis IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IDA
GO:0005764 lysosome IDA
GO:0005768 endosome IDA
GO:0005794 Golgi apparatus IEA
GO:0005829 cytosol IEA
GO:0010008 endosome membrane IDA
GO:0016020 membrane IDA
GO:0019898 extrinsic component of membrane IBA
GO:0030027 lamellipodium IEA
GO:0030904 retromer complex IDA
GO:0030905 retromer, tubulation complex NAS
GO:0031901 early endosome membrane IDA
GO:0031982 vesicle IDA
GO:0043231 intracellular membrane-bounded organelle IDA
GO:0043234 protein complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8638121 Enhanced degradation of EGF receptors by a sorting nexin, SNX1.
9819414 Identification of a family of sorting nexin molecules and characterization of their association with receptors.
11102511 Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.
11997453 Endosomal localization and function of sorting nexin 1.
12198132 The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15498486 Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.
15673616 Determinants of the endosomal localization of sorting nexin 1.
16407403 An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins.
16572171 Analysis of the DNA sequence and duplication history of human chromosome 15.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17101778 Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.
17550970 The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network.
18088323 SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.
18669648 A quantitative atlas of mitotic phosphorylation.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19619496 The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19816406 Amphipathic motifs in BAR domains are essential for membrane curvature sensing.
19874558 Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes.
19935774 The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20070609 Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent.
20604901 A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling.
21040701 Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking.
21269460 Initial characterization of the human central proteome.
22431521 The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.
23085988 Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules.
23152498 Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
G02522 G02522 PIR
Phox IPR001683 InterPro
Sorting_nexin_N IPR005329 InterPro
Vps5_C IPR015404 InterPro
AH/BAR_dom_sf IPR027267 InterPro
SNX1 IPR028660 InterPro
PX_SNX1 IPR034901 InterPro
PX_dom_sf IPR036871 InterPro
PX PF00787 Pfam
Sorting_nexin PF03700 Pfam
Vps5 PF09325 Pfam
PTHR10555:SF129 PTHR10555:SF129 PANTHER
SSF103657 SSF103657 SUPFAM
SSF64268 SSF64268 SUPFAM
PX_SNX1 cd07281 CDD