Protein: P15822

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P15822 (Uniprot) ZEP1_HUMAN HIVEP1 Zinc finger protein 40 human No
Uniprot: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 330 GO:0006396 RNA processing 426 5.60e-03 3.14e-16
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
52 GO:0090304 nucleic acid metabolic process
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
426 GO:0008380 RNA splicing
426 GO:0006397 mRNA processing
426 GO:0051252 regulation of RNA metabolic process
426 GO:2000112 regulation of cellular macromolecule biosynthetic process
426 GO:0010468 regulation of gene expression
426 GO:0006351 transcription, DNA-templated
469 GO:0060255 regulation of macromolecule metabolic process
479 GO:0016070 RNA metabolic process
479 GO:0034645 cellular macromolecule biosynthetic process
479 GO:0044271 cellular nitrogen compound biosynthetic process
479 GO:0044267 cellular protein metabolic process
479 GO:0010468 regulation of gene expression
479 GO:0007165 signal transduction
569 GO:0007165 signal transduction
591 GO:0016070 RNA metabolic process
591 GO:0010467 gene expression
591 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
52 GO:0005829 cytosol
52 GO:0043232 intracellular non-membrane-bounded organelle
52 GO:0005654 nucleoplasm
143 GO:0005634 nucleus
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
426 GO:0005654 nucleoplasm
469 GO:0043232 intracellular non-membrane-bounded organelle
469 GO:0005634 nucleus
479 GO:0070013 intracellular organelle lumen
479 GO:0044428 nuclear part
591 GO:0031981 nuclear lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA
GO:0006366 transcription from RNA polymerase II promoter IBA
GO:0007165 signal transduction IBA
GO:0007275 multicellular organism development IBA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm IDA
GO:0005739 mitochondrion IDA
GO:0016604 nuclear body IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1567844 High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1.
1727488 Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products.
2106471 A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence.
2108316 A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes.
2248949 High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution.
8289330 Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression.
11818340 GAAP-1: a transcriptional activator of p53 and IRF-1 possesses pro-apoptotic activity.
14574404 The DNA sequence and analysis of human chromosome 6.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19732766 Cirhin up-regulates a canonical NF-kappaB element through strong interaction with Cirip/HIVEP1.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
A34203 A34203 PIR
Znf_RING/FYVE/PHD IPR013083 InterPro
Znf_C2H2_type IPR013087 InterPro
ZF_CCHC_HIVEP IPR034729 InterPro
Znf_C2H2_sf IPR036236 InterPro
ZINC_FINGER_C2H2_1 PS00028 PROSITE
ZINC_FINGER_C2H2_2 PS50157 PROSITE
ZF_CCHC_HIVEP PS51811 PROSITE
ZnF_C2H2 SM00355 SMART
SSF57667 SSF57667 SUPFAM