Protein: P15822 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P15822 (Uniprot)	ZEP1_HUMAN	HIVEP1	Zinc finger protein 40	human	No

Protein Function

Uniprot: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, in more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0036211	protein modification process	330	GO:0006396	RNA processing	426	5.60e-03	3.14e-16

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
52	GO:0090304	nucleic acid metabolic process
330	GO:0006464	cellular protein modification process
330	GO:0006796	phosphate-containing compound metabolic process
330	GO:0031325	positive regulation of cellular metabolic process
330	GO:0010604	positive regulation of macromolecule metabolic process
330	GO:0051173	positive regulation of nitrogen compound metabolic process
330	GO:2000112	regulation of cellular macromolecule biosynthetic process
330	GO:0010468	regulation of gene expression
330	GO:0019219	regulation of nucleobase-containing compound metabolic process
330	GO:0051246	regulation of protein metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
52	GO:0005829	cytosol
52	GO:0043232	intracellular non-membrane-bounded organelle
52	GO:0005654	nucleoplasm
143	GO:0005634	nucleus
330	GO:0005829	cytosol
330	GO:0005654	nucleoplasm
426	GO:0005654	nucleoplasm
469	GO:0043232	intracellular non-membrane-bounded organelle
469	GO:0005634	nucleus
479	GO:0070013	intracellular organelle lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA
GO:0006366	transcription from RNA polymerase II promoter	IBA
GO:0007165	signal transduction	IBA
GO:0007275	multicellular organism development	IBA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	IDA
GO:0005739	mitochondrion	IDA
GO:0016604	nuclear body	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ALDOB_HUMAN	Yes: P05062 (MoonDB)
APH1A_HUMAN	No
APTX_HUMAN	No
ASGR1_HUMAN	No
ATX1_HUMAN	Yes: P54253 (MoonDB)
ATX1L_HUMAN	No
BHE40_HUMAN	Yes: O14503 (MoonDB)
BNIP3_HUMAN	No
BRCA1_HUMAN	No
CAC1A_HUMAN	No

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Publications Associated

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PMID	Article Title
1567844	High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1.
1727488	Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products.
2106471	A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence.
2108316	A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes.
2248949	High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution.
8289330	Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression.
11818340	GAAP-1: a transcriptional activator of p53 and IRF-1 possesses pro-apoptotic activity.
14574404	The DNA sequence and analysis of human chromosome 6.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
A34203	A34203	PIR
SSF57667	SSF57667	SUPFAM
ZF_CCHC_HIVEP	IPR034729	InterPro
ZF_CCHC_HIVEP	PS51811	PROSITE
ZINC_FINGER_C2H2_1	PS00028	PROSITE
ZINC_FINGER_C2H2_2	PS50157	PROSITE
ZnF_C2H2	SM00355	SMART
Znf_C2H2_sf	IPR036236	InterPro
Znf_C2H2_type	IPR013087	InterPro
Znf_RING/FYVE/PHD	IPR013083	InterPro

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