Protein: O14503

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O14503 (Uniprot) BHE40_HUMAN BHLHE40 Class E basic helix-loop-helix protein 40 human No
Uniprot: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 25, 26 GO:0006396 RNA processing 426 5.60e-03 3.14e-16
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
7 GO:0031324 negative regulation of cellular metabolic process
7 GO:0010605 negative regulation of macromolecule metabolic process
7 GO:0051172 negative regulation of nitrogen compound metabolic process
7 GO:0010604 positive regulation of macromolecule metabolic process
7 GO:0006357 regulation of transcription from RNA polymerase II promoter
25 GO:0006464 cellular protein modification process
25 GO:0010467 gene expression
25 GO:0060255 regulation of macromolecule metabolic process
25 GO:0007165 signal transduction
26 GO:0006464 cellular protein modification process
26 GO:0090304 nucleic acid metabolic process
26 GO:0010468 regulation of gene expression
209 GO:0031324 negative regulation of cellular metabolic process
209 GO:0010605 negative regulation of macromolecule metabolic process
209 GO:0051172 negative regulation of nitrogen compound metabolic process
209 GO:0009893 positive regulation of metabolic process
209 GO:0006357 regulation of transcription from RNA polymerase II promoter
209 GO:0007165 signal transduction
380 GO:0010467 gene expression
380 GO:0019538 protein metabolic process
380 GO:0060255 regulation of macromolecule metabolic process
426 GO:0008380 RNA splicing
426 GO:0006397 mRNA processing
426 GO:0051252 regulation of RNA metabolic process
426 GO:2000112 regulation of cellular macromolecule biosynthetic process
426 GO:0010468 regulation of gene expression
426 GO:0006351 transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
7 GO:0005654 nucleoplasm
25 GO:0005829 cytosol
25 GO:0005634 nucleus
26 GO:0005654 nucleoplasm
60 GO:0005634 nucleus
89 GO:0005634 nucleus
209 GO:0005654 nucleoplasm
380 GO:0005634 nucleus
426 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0006351 transcription, DNA-templated IEA
GO:0006355 regulation of transcription, DNA-templated NAS
GO:0032922 circadian regulation of gene expression IDA
GO:0043153 entrainment of circadian clock by photoperiod ISS
GO:0043433 negative regulation of DNA binding transcription factor activity IDA
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus NAS
GO:0005737 cytoplasm IEA
GO:0016604 nuclear body IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
RBPMS_HUMAN Yes: Q93062 (MoonDB)
PO6F2_HUMAN No
DAB1_HUMAN No
PR20D_HUMAN No
DAZP2_HUMAN Yes: Q15038 (MoonDB)
KR195_HUMAN No
KRA81_HUMAN No
RFOX1_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
KRA62_HUMAN No
CSK21_HUMAN Yes: P68400 (MoonDB)
BYST_HUMAN No
GMCLL_HUMAN No
VENTX_HUMAN No
ATX1_HUMAN Yes: P54253 (MoonDB)
RBPS2_HUMAN No
CALL3_HUMAN No
KR231_HUMAN No
2A5D_HUMAN No
2A5E_HUMAN No
2AAA_HUMAN No
2AAB_HUMAN No
AAMP_HUMAN No
AAPK1_HUMAN No
APH1A_HUMAN No
ARIP4_HUMAN No
B7ZLI8_HUMAN No
BRD7_HUMAN No
CCNK_HUMAN No
CDPF1_HUMAN No
CHD3_HUMAN Yes: Q12873 (MoonDB)
CNRG_HUMAN No
COX5B_HUMAN No
CREM_HUMAN No
CSK22_HUMAN No
CSK2B_HUMAN Yes: P67870 (MoonDB)
DVL3_HUMAN Yes: Q92997 (MoonDB)
ECHP_HUMAN No
ENOA_HUMAN Yes: P06733 (MoonDB)
EZH2_HUMAN No
FA46B_HUMAN No
FA83A_HUMAN No
FBLN1_HUMAN No
FXL15_HUMAN No
KLD7B_HUMAN No
KR191_HUMAN No
LARP4_HUMAN No
LASP1_HUMAN No
LMO3_HUMAN No
MAGD1_HUMAN No
MCRS1_HUMAN No
NAA50_HUMAN No
NEK6_HUMAN No
NFIL3_HUMAN No
NOC4L_HUMAN No
NONO_HUMAN No
NPAS2_HUMAN No
NR1D2_HUMAN No
NUMBL_HUMAN No
PFD5_HUMAN No
PHF1_HUMAN No
PKHB2_HUMAN No
PP1A_HUMAN Yes: P62136 (MoonDB)
PP1B_HUMAN No
PP1G_HUMAN Yes: P36873 (MoonDB)
PP2AA_HUMAN No
RBM23_HUMAN No
RHBT3_HUMAN No
RHOJ_HUMAN No
ROR2_HUMAN No
RORB_HUMAN No
RORG_HUMAN No
SETB1_HUMAN No
SMAP2_HUMAN No
SMYD1_HUMAN No
SNAT_HUMAN No
SOGA1_HUMAN No
SOX15_HUMAN No
STK19_HUMAN No
TFE2_HUMAN No
TOB2_HUMAN No
TOLIP_HUMAN No
TTC23_HUMAN No
TXN4B_HUMAN No
UBC9_HUMAN Yes: P63279 (MoonDB)
UBP54_HUMAN No
VAC14_HUMAN No
VIME_HUMAN Yes: P08670 (MoonDB)
WT1_HUMAN No
ZEP1_HUMAN Yes: P15822 (MoonDB)
ZFHX3_HUMAN No
ZHX1_HUMAN No
PMID Article Title
9240428 Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes.
11226878 Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2.
11278694 Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway.
12397359 Dec1 and Dec2 are regulators of the mammalian molecular clock.
14672706 A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.
15193144 DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15560782 Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1.
18411297 DEC1 modulates the circadian phase of clock gene expression.
19786558 The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.
21829689 SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner.
25755297 System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
25772364 SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
Orange_dom IPR003650 InterPro
bHLH_dom IPR011598 InterPro
HLH_DNA-bd_sf IPR036638 InterPro
JC5547 JC5547 PIR
HLH PF00010 Pfam
Hairy_orange PF07527 Pfam
BHLH PS50888 PROSITE
ORANGE PS51054 PROSITE
HLH SM00353 SMART
ORANGE SM00511 SMART
SSF47459 SSF47459 SUPFAM
HLH cd00083 CDD