Protein: P08670

Uniprot: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 27, 132 GO:0007165 signal transduction 609 1.10e-111 5.07e-25
GO:0034641 cellular nitrogen compound metabolic process 267 GO:0007165 signal transduction 609 4.22e-144 6.90e-18
GO:0007165 signal transduction 609 GO:0006725 cellular aromatic compound metabolic process 81 5.44e-126 5.27e-27
Module ID (MoonGO) GO ID (BP) GO Name
27 GO:0090304 nucleic acid metabolic process
27 GO:0060255 regulation of macromolecule metabolic process
51 GO:0060255 regulation of macromolecule metabolic process
81 GO:0006139 nucleobase-containing compound metabolic process
99 GO:0031325 positive regulation of cellular metabolic process
99 GO:0010628 positive regulation of gene expression
99 GO:0051173 positive regulation of nitrogen compound metabolic process
99 GO:0019538 protein metabolic process
99 GO:0006357 regulation of transcription from RNA polymerase II promoter
99 GO:0007165 signal transduction
132 GO:0090304 nucleic acid metabolic process
132 GO:0060255 regulation of macromolecule metabolic process
167 GO:0016070 RNA metabolic process
167 GO:0010467 gene expression
167 GO:0060255 regulation of macromolecule metabolic process
191 GO:0006355 regulation of transcription, DNA-templated
207 GO:0007165 signal transduction
267 GO:0044271 cellular nitrogen compound biosynthetic process
267 GO:0010467 gene expression
267 GO:0009059 macromolecule biosynthetic process
267 GO:0090304 nucleic acid metabolic process
267 GO:0019538 protein metabolic process
267 GO:0060255 regulation of macromolecule metabolic process
344 GO:0010467 gene expression
344 GO:0019538 protein metabolic process
344 GO:0060255 regulation of macromolecule metabolic process
344 GO:0007165 signal transduction
383 GO:0044267 cellular protein metabolic process
383 GO:0006355 regulation of transcription, DNA-templated
413 GO:0044267 cellular protein metabolic process
413 GO:0031326 regulation of cellular biosynthetic process
413 GO:0010468 regulation of gene expression
413 GO:0010556 regulation of macromolecule biosynthetic process
413 GO:0007165 signal transduction
413 GO:0006351 transcription, DNA-templated
427 GO:0044267 cellular protein metabolic process
427 GO:0010467 gene expression
427 GO:0060255 regulation of macromolecule metabolic process
430 GO:0019538 protein metabolic process
431 GO:0019538 protein metabolic process
431 GO:0060255 regulation of macromolecule metabolic process
485 GO:0034645 cellular macromolecule biosynthetic process
485 GO:0090304 nucleic acid metabolic process
550 GO:0006355 regulation of transcription, DNA-templated
609 GO:0007166 cell surface receptor signaling pathway
609 GO:0006464 cellular protein modification process
609 GO:0071310 cellular response to organic substance
609 GO:0031325 positive regulation of cellular metabolic process
609 GO:0010604 positive regulation of macromolecule metabolic process
609 GO:0051173 positive regulation of nitrogen compound metabolic process
609 GO:0051246 regulation of protein metabolic process
609 GO:0006355 regulation of transcription, DNA-templated
645 GO:0060255 regulation of macromolecule metabolic process
658 GO:0019538 protein metabolic process
743 GO:0007165 signal transduction
767 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
18 GO:0005829 cytosol
18 GO:0070062 extracellular exosome
27 GO:0031981 nuclear lumen
51 GO:0005634 nucleus
81 GO:0005829 cytosol
81 GO:0031981 nuclear lumen
84 GO:0005634 nucleus
89 GO:0005634 nucleus
99 GO:0005654 nucleoplasm
132 GO:0005634 nucleus
140 GO:0043232 intracellular non-membrane-bounded organelle
167 GO:0005654 nucleoplasm
191 GO:0031981 nuclear lumen
207 GO:0005829 cytosol
207 GO:0005654 nucleoplasm
267 GO:0005829 cytosol
267 GO:0070013 intracellular organelle lumen
267 GO:0005634 nucleus
344 GO:0070013 intracellular organelle lumen
344 GO:0005634 nucleus
383 GO:0070013 intracellular organelle lumen
383 GO:0044428 nuclear part
413 GO:0005654 nucleoplasm
427 GO:0070013 intracellular organelle lumen
431 GO:0005829 cytosol
485 GO:0043232 intracellular non-membrane-bounded organelle
485 GO:0005634 nucleus
550 GO:0005634 nucleus
609 GO:0005829 cytosol
609 GO:0043232 intracellular non-membrane-bounded organelle
609 GO:0070013 intracellular organelle lumen
609 GO:0005634 nucleus
609 GO:0005886 plasma membrane
645 GO:0005829 cytosol
645 GO:0005634 nucleus
658 GO:0005634 nucleus
743 GO:0012505 endomembrane system
767 GO:0005829 cytosol
767 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006928 movement of cell or subcellular component TAS
GO:0010628 positive regulation of gene expression IEA
GO:0010977 negative regulation of neuron projection development IEA
GO:0014002 astrocyte development IEA
GO:0016032 viral process IEA
GO:0030049 muscle filament sliding TAS
GO:0045109 intermediate filament organization IEA
GO:0060020 Bergmann glial cell differentiation IEA
GO:0060395 SMAD protein signal transduction IEA
GO:0070307 lens fiber cell development IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IDA
GO:0005777 peroxisome IDA
GO:0005829 cytosol TAS
GO:0005856 cytoskeleton IDA
GO:0005882 intermediate filament IDA
GO:0005886 plasma membrane IDA
GO:0005925 focal adhesion IDA
GO:0031012 extracellular matrix IDA
GO:0031252 cell leading edge IEA
GO:0043005 neuron projection IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005777 peroxisome GO:0005886 plasma membrane 3.22e-02 5.86e-04
GO:0005829 cytosol GO:0031012 extracellular matrix 4.46e-06 5.18e-08
GO:0005882 intermediate filament GO:0005886 plasma membrane 1.25e-05 3.95e-105
Interactor Also a MoonDB EMF protein
K2C75_HUMAN No
NFL_HUMAN No
TRI14_HUMAN No
KIFC3_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
PSA1_HUMAN No
CRCT1_HUMAN No
RPAC1_HUMAN No
MTNB_HUMAN No
PERI_HUMAN No
BYST_HUMAN No
TCEA2_HUMAN No
PPL13_HUMAN No
GEM_HUMAN No
NIF3L_HUMAN No
ING5_HUMAN No
CBX8_HUMAN No
STX1A_HUMAN No
K1C20_HUMAN No
TXLNB_HUMAN No
THIOM_HUMAN No
GFAP_HUMAN No
C2CD6_HUMAN No
PPR18_HUMAN No
BHE40_HUMAN Yes: O14503 (MoonDB)
PKN1_HUMAN No
F107A_HUMAN No
F161A_HUMAN No
ZN572_HUMAN No
Q8IVT4_HUMAN No
PNMA5_HUMAN No
SCNM1_HUMAN No
HSPB1_HUMAN Yes: P04792 (MoonDB)
GRB2_HUMAN Yes: P62993 (MoonDB)
SUMO3_HUMAN No
SH3G1_HUMAN No
FUBP1_HUMAN No
ATN1_HUMAN No
DESM_HUMAN No
HAP1_HUMAN No
NEK6_HUMAN No
CNTRL_HUMAN No
SETB1_HUMAN No
SIR6_HUMAN No
KIF9_HUMAN No
NOC4L_HUMAN No
CREB1_HUMAN No
B7ZLI8_HUMAN No
1433B_HUMAN No
ABLM1_HUMAN No
ACTB_HUMAN No
ADT3_HUMAN No
ANR35_HUMAN No
ANXA7_HUMAN No
APLP1_HUMAN No
ARMC7_HUMAN No
ARMX2_HUMAN No
BRD1_HUMAN No
C19L2_HUMAN No
CAN1_HUMAN No
CASP8_HUMAN No
CDN1A_HUMAN Yes: P38936 (MoonDB)
CE126_HUMAN No
CHD3_HUMAN Yes: Q12873 (MoonDB)
CSN6_HUMAN No
CT55_HUMAN No
DCUP_HUMAN No
DESP_HUMAN No
DGC14_HUMAN No
DI3L2_HUMAN No
DPPA4_HUMAN No
DPYL1_HUMAN No
F118B_HUMAN No
FABP4_HUMAN No
GA45A_HUMAN No
GCP4_HUMAN No
GOPC_HUMAN No
GSK3B_HUMAN No
HABP4_HUMAN No
HM20B_HUMAN No
IKBD_HUMAN No
IP6K1_HUMAN No
K0408_HUMAN No
KAT7_HUMAN No
KIF15_HUMAN No
LORI_HUMAN No
LRIF1_HUMAN No
MA2A2_HUMAN No
MAFG_HUMAN No
MD1L1_HUMAN No
NCTR1_HUMAN No
NFAC2_HUMAN No
NFM_HUMAN No
NOD2_HUMAN No
NR1H2_HUMAN Yes: P55055 (MoonDB)
NS1BP_HUMAN No
PAIRB_HUMAN No
PDLI1_HUMAN No
PEPL_HUMAN No
PIAS4_HUMAN No
PPHLN_HUMAN No
PRAF1_HUMAN No
PRS8_HUMAN No
PSMD7_HUMAN No
PSME1_HUMAN No
PUF60_HUMAN No
Q5VU21_HUMAN No
RAD51_HUMAN No
RBM48_HUMAN No
RERE_HUMAN No
RFA1_HUMAN No
RIBC2_HUMAN No
RIF1_HUMAN No
RM44_HUMAN No
S27A6_HUMAN No
SDCG3_HUMAN No
SH3G3_HUMAN No
SH3Y1_HUMAN No
SRRT_HUMAN No
SUMO2_HUMAN No
SYK_HUMAN No
SYN1_HUMAN No
T22D1_HUMAN No
TAB2_HUMAN No
TARA_HUMAN No
TBA1C_HUMAN No
TCHP_HUMAN No
THIO_HUMAN No
TIF1B_HUMAN No
TNNT1_HUMAN No
TNR14_HUMAN No
TRI15_HUMAN Yes: Q9C019 (MoonDB)
TTHY_HUMAN No
UBB_HUMAN Yes: P0CG47 (MoonDB)
UT14A_HUMAN No
XRCC4_HUMAN No
YAED1_HUMAN No
ZHX1_HUMAN No
PMID Article Title
2251132 Nucleotide sequence of cDNA covering the complete coding part of the human vimentin gene.
2323579 Isolation of a human vimentin cDNA with a long 3'-noncoding region from a human osteosarcoma cell line (MG-63).
2472876 Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells.
3371665 Nucleotide sequence of the human vimentin gene and regulation of its transcription in tissues and cultured cells.
3467175 Coding sequence and growth regulation of the human vimentin gene.
9150946 Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.
9175763 Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN.
11243787 Divide-and-conquer crystallographic approach towards an atomic structure of intermediate filaments.
11889032 Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly.
12458200 Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14762106 Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments.
14996095 SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.
15164054 The DNA sequence and comparative analysis of human chromosome 10.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15846844 Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.
16361107 Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics.
16923132 Interactions between epiplakin and intermediate filaments.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17505058 Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).
17924679 Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
18220336 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18811945 The serine/threonine kinase Stk33 exhibits autophosphorylation and phosphorylates the intermediate filament protein Vimentin.
18827015 TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.
19126778 Dominant cataract formation in association with a vimentin assembly disrupting mutation.
19270731 The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068230 Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20176112 Atomic structure of vimentin coil 2.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21465480 Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils.
21746880 A novel role of vimentin filaments: binding and stabilization of collagen mRNAs.
22119849 Stabilization of vimentin coil2 fragment via an engineered disulfide.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22905912 Resveratrol-induced changes of the human adipocyte secretion profile.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23325789 cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
25417112 Target-selective protein S-nitrosylation by sequence motif recognition.
25944712 N-terminome analysis of the human mitochondrial proteome.
26694549 Sporadic and familial congenital cataracts: mutational spectrum and new diagnoses using next-generation sequencing.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
28450710 Targeted exome sequencing of congenital cataracts related genes: broadening the mutation spectrum and genotype-phenotype correlations in 27 Chinese Han families.
OMIM ID Disease Name
116300 Cataract 30, multiple types
Domain Name Domain ID Source
IF IPR001664 InterPro
Intermed_filament_DNA-bd IPR006821 InterPro
Intermediate_filament_CS IPR018039 InterPro
Vimentin IPR027699 InterPro
Filament PF00038 Pfam
Filament_head PF04732 Pfam
IF_ROD_1 PS00226 PROSITE
IF_ROD_2 PS51842 PROSITE
PTHR23239 PTHR23239 PANTHER
PTHR23239:SF27 PTHR23239:SF27 PANTHER
A25074 S13115 PIR
Filament SM01391 SMART