Protein: P36873 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P36873 (Uniprot)	PP1G_HUMAN	PPP1CC	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	human	No

Protein Function

Uniprot: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein sy more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169, 534	GO:0006725	cellular aromatic compound metabolic process	345, 585	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 151 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
2	GO:0044267	cellular protein metabolic process
2	GO:0010467	gene expression
2	GO:0006139	nucleobase-containing compound metabolic process
2	GO:0060255	regulation of macromolecule metabolic process
2	GO:0007165	signal transduction
25	GO:0006464	cellular protein modification process
25	GO:0010467	gene expression
25	GO:0060255	regulation of macromolecule metabolic process
25	GO:0007165	signal transduction
26	GO:0006464	cellular protein modification process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
2	GO:0005829	cytosol
2	GO:0005634	nucleus
25	GO:0005829	cytosol
25	GO:0005634	nucleus
26	GO:0005654	nucleoplasm
51	GO:0005634	nucleus
105	GO:0005634	nucleus
106	GO:0005829	cytosol
106	GO:0005654	nucleoplasm
107	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

Showing 1 to 9 of 9 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0005977	glycogen metabolic process	IEA
GO:0006470	protein dephosphorylation	IMP
GO:0007062	sister chromatid cohesion	TAS
GO:0030182	neuron differentiation	IEA
GO:0032922	circadian regulation of gene expression	ISS
GO:0042752	regulation of circadian rhythm	IMP
GO:0043153	entrainment of circadian clock by photoperiod	ISS
GO:0046822	regulation of nucleocytoplasmic transport	IEA
GO:0051301	cell division	IEA

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Cellular Components

Showing 1 to 10 of 15 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000777	condensed chromosome kinetochore	IEA
GO:0000784	nuclear chromosome, telomeric region	IDA
GO:0005634	nucleus	IDA
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IDA
GO:0005739	mitochondrion	IDA
GO:0005741	mitochondrial outer membrane	IEA
GO:0005829	cytosol	TAS
GO:0005925	focal adhesion	IDA
GO:0016607	nuclear speck	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 164 entries

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Interactor	Also a MoonDB EMF protein
A1DRY3_HUMAN	No
ABT1_HUMAN	No
ACAD8_HUMAN	No
ANR42_HUMAN	No
ARF_HUMAN	No
ASH2L_HUMAN	No
ASPP1_HUMAN	No
ASPP2_HUMAN	No
ATD3A_HUMAN	No
ATM_HUMAN	No

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Publications Associated

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PMID	Article Title
7500362	Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate.
7556599	The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.
8111128	Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA.
8394140	Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2.
9414128	PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1.
11535607	Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1.
11564868	Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.
11739654	Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.
12226088	Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.
12529430	Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 12 entries

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Domain Name	Domain ID	Source
Calcineurin-like_PHP_ApaH	IPR004843	InterPro
Metallo-depent_PP-like	IPR029052	InterPro
Metallophos	PF00149	Pfam
PP2Ac	SM00156	SMART
S35699	S35699	PIR
S35700	S35700	PIR
Ser/Thr-sp_prot-phosphatase	IPR006186	InterPro
SER_THR_PHOSPHATASE	PS00125	PROSITE
SSF56300	SSF56300	SUPFAM
STPHPHTASE	PR00114	PRINTS

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