Protein: P12004 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P12004 (Uniprot)	PCNA_HUMAN	PCNA	Proliferating cell nuclear antigen	human	No

Protein Function

Uniprot: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) en more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006725	cellular aromatic compound metabolic process	239	GO:0007165	signal transduction	308	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
79	GO:0007165	signal transduction
93	GO:0034645	cellular macromolecule biosynthetic process
93	GO:0034654	nucleobase-containing compound biosynthetic process
93	GO:0019538	protein metabolic process
93	GO:0051252	regulation of RNA metabolic process
93	GO:0010468	regulation of gene expression
173	GO:0034645	cellular macromolecule biosynthetic process
173	GO:0006464	cellular protein modification process
173	GO:0010467	gene expression
173	GO:0035556	intracellular signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
34	GO:0005634	nucleus
79	GO:0005634	nucleus
93	GO:0005829	cytosol
93	GO:0005634	nucleus
173	GO:0005654	nucleoplasm
177	GO:0005634	nucleus
181	GO:0005829	cytosol
181	GO:0005654	nucleoplasm
196	GO:0005634	nucleus
239	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	TAS
GO:0000723	telomere maintenance	TAS
GO:0006266	DNA ligation	TAS
GO:0006272	leading strand elongation	IBA
GO:0006283	transcription-coupled nucleotide-excision repair	TAS
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	TAS
GO:0006297	nucleotide-excision repair, DNA gap filling	TAS
GO:0006298	mismatch repair	TAS
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS
GO:0007507	heart development	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000784	nuclear chromosome, telomeric region	IDA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005657	replication fork	IDA
GO:0005663	DNA replication factor C complex	TAS
GO:0005813	centrosome	IDA
GO:0016604	nuclear body	IDA
GO:0030894	replisome	TAS
GO:0043596	nuclear replication fork	IDA
GO:0043626	PCNA complex	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35
GO:0016604	nuclear body	GO:0070062	extracellular exosome	1.52e-08	2.57e-155

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ALDOA_HUMAN	No
ANXA2_HUMAN	No
BACD1_HUMAN	No
CAH2_HUMAN	No
CBX1_HUMAN	No
CCNO_HUMAN	No
CDAN1_HUMAN	No
CDC6_HUMAN	No
CDN1A_HUMAN	Yes: P38936 (MoonDB)
CDN1C_HUMAN	No

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Publications Associated

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PMID	Article Title
2565339	Structure of the human gene for the proliferating cell nuclear antigen.
2882422	The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro.
2882507	Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.
8861913	Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA.
9302295	Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1.
9305916	The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21.
9566895	Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase.
11376153	Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen.
11595739	Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.
11780052	The DNA sequence and comparative analysis of human chromosome 20.

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OMIM Diseases Associated

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OMIM ID	Disease Name
615919	Ataxia-telangiectasia-like disorder 2

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Protein Domains Associated

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Domain Name	Domain ID	Source
DNApol_clamp_arch	MF_00317	HAMAP
pcna	TIGR00590	TIGRFAMs
PCNA_1	PS01251	PROSITE
PCNA_2	PS00293	PROSITE
PCNA_C	PF02747	Pfam
PCNA_N	PF00705	Pfam
PCNACYCLIN	PR00339	PRINTS
Pr_cel_nuc_antig	IPR000730	InterPro
Pr_cel_nuc_antig_C	IPR022649	InterPro
Pr_cel_nuc_antig_CS	IPR022659	InterPro

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