Protein: P63208 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P63208 (Uniprot)	SKP1_HUMAN	SKP1	S-phase kinase-associated protein 1	human	No

Protein Function

Uniprot: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of t more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006793	phosphorus metabolic process	491	GO:0009059	macromolecule biosynthetic process	87	1.25e-35	4.53e-23

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
24	GO:0016070	RNA metabolic process
24	GO:0006464	cellular protein modification process
24	GO:0034654	nucleobase-containing compound biosynthetic process
24	GO:0006796	phosphate-containing compound metabolic process
24	GO:0031325	positive regulation of cellular metabolic process
24	GO:0010604	positive regulation of macromolecule metabolic process
24	GO:0051173	positive regulation of nitrogen compound metabolic process
24	GO:2000112	regulation of cellular macromolecule biosynthetic process
24	GO:0010468	regulation of gene expression
24	GO:0019219	regulation of nucleobase-containing compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
24	GO:0005829	cytosol
24	GO:0005654	nucleoplasm
87	GO:0005634	nucleus
106	GO:0005829	cytosol
106	GO:0005654	nucleoplasm
159	GO:0005829	cytosol
159	GO:0005654	nucleoplasm
162	GO:0005634	nucleus
216	GO:0005829	cytosol
218	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000086	G2/M transition of mitotic cell cycle	TAS
GO:0000209	protein polyubiquitination	TAS
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
GO:0006879	cellular iron ion homeostasis	TAS
GO:0010265	SCF complex assembly	TAS
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	TAS
GO:0016055	Wnt signaling pathway	TAS
GO:0016567	protein ubiquitination	IDA
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS
GO:0035518	histone H2A monoubiquitination	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0019005	SCF ubiquitin ligase complex	IDA
GO:0031467	Cul7-RING ubiquitin ligase complex	IDA
GO:0031519	PcG protein complex	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A0A0B4J1Y2_HUMAN	No
A26L1_HUMAN	No
CCNA2_HUMAN	No
CDCA3_HUMAN	No
CDK2_HUMAN	No
CDK4_HUMAN	No
CDN1A_HUMAN	Yes: P38936 (MoonDB)
CDN1B_HUMAN	Yes: P46527 (MoonDB)
CENPE_HUMAN	No
CKS1_HUMAN	No

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Publications Associated

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PMID	Article Title
7553852	p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.
8530064	A novel cDNA with homology to an RNA polymerase II elongation factors maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l).
9031623	Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13-12qter.
11099048	Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
11389839	Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
11961546	Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex.
12481031	CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.
12820959	Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16209941	Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
E3_ubiquit_lig_SCF_Skp	PIRSF028729	PIRSF
I39170	I39170	PIR
SKP1	IPR016897	InterPro
Skp1	PF01466	Pfam
Skp1	SM00512	SMART
SKP1-like	IPR001232	InterPro
SKP1-like_dim_sf	IPR036296	InterPro
SKP1/BTB/POZ_sf	IPR011333	InterPro
Skp1_comp_dimer	IPR016072	InterPro
Skp1_comp_POZ	IPR016073	InterPro

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