Protein: P46527 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P46527 (Uniprot)	CDN1B_HUMAN	CDKN1B	Cyclin-dependent kinase inhibitor 1B	human	No

Protein Function

Uniprot: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes an more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009059	macromolecule biosynthetic process	173	GO:0006793	phosphorus metabolic process	491	1.25e-35	4.53e-23

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
6	GO:0034645	cellular macromolecule biosynthetic process
6	GO:0010467	gene expression
6	GO:0090304	nucleic acid metabolic process
6	GO:0060255	regulation of macromolecule metabolic process
73	GO:0006355	regulation of transcription, DNA-templated
173	GO:0034645	cellular macromolecule biosynthetic process
173	GO:0006464	cellular protein modification process
173	GO:0010467	gene expression
173	GO:0035556	intracellular signal transduction
173	GO:0090304	nucleic acid metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
6	GO:0043232	intracellular non-membrane-bounded organelle
6	GO:0005654	nucleoplasm
73	GO:0005634	nucleus
173	GO:0005654	nucleoplasm
218	GO:0005634	nucleus
330	GO:0005829	cytosol
330	GO:0005654	nucleoplasm
491	GO:0005829	cytosol
491	GO:0043232	intracellular non-membrane-bounded organelle
491	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	TAS
GO:0000082	G1/S transition of mitotic cell cycle	TAS
GO:0001666	response to hypoxia	IEA
GO:0001890	placenta development	IEA
GO:0006813	potassium ion transport	IEA
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS
GO:0007050	cell cycle arrest	IMP
GO:0007096	regulation of exit from mitosis	IEA
GO:0007219	Notch signaling pathway	IEA
GO:0007605	sensory perception of sound	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005768	endosome	IEA
GO:0005829	cytosol	TAS
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	IDA
GO:0043231	intracellular membrane-bounded organelle	IDA
GO:0043234	protein complex	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005768	endosome	4.09e-12	7.34e-15
GO:0005654	nucleoplasm	GO:0005768	endosome	1.29e-11	1.85e-14

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AKT1_HUMAN	No
BANP_HUMAN	No
CCNA1_HUMAN	No
CCNA2_HUMAN	No
CCND1_HUMAN	No
CCND2_HUMAN	No
CCND3_HUMAN	No
CCNE1_HUMAN	No
CCNE2_HUMAN	No
CDK2_HUMAN	No

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Publications Associated

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PMID	Article Title
7882309	Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.
8033212	Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
8684460	Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
10323868	Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
10831586	Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.
12042314	Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
12093740	A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.
12244301	PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
12244303	Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
12972555	Spy1 interacts with p27Kip1 to allow G1/S progression.

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OMIM Diseases Associated

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OMIM ID	Disease Name
610755	Multiple endocrine neoplasia 4

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Protein Domains Associated

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Domain Name	Domain ID	Source
CDI	IPR003175	InterPro
CDI	PF02234	Pfam
CDKN1B	IPR029843	InterPro
PTHR10265	PTHR10265	PANTHER
PTHR10265:SF9	PTHR10265:SF9	PANTHER

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