Protein: P46527

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P46527 (Uniprot) CDN1B_HUMAN CDKN1B Cyclin-dependent kinase inhibitor 1B human No
Uniprot: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 173 GO:0006793 phosphorus metabolic process 491 1.25e-35 4.53e-23
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
6 GO:0034645 cellular macromolecule biosynthetic process
6 GO:0010467 gene expression
6 GO:0090304 nucleic acid metabolic process
6 GO:0060255 regulation of macromolecule metabolic process
73 GO:0006355 regulation of transcription, DNA-templated
173 GO:0034645 cellular macromolecule biosynthetic process
173 GO:0006464 cellular protein modification process
173 GO:0010467 gene expression
173 GO:0035556 intracellular signal transduction
173 GO:0090304 nucleic acid metabolic process
173 GO:0016310 phosphorylation
173 GO:0031325 positive regulation of cellular metabolic process
173 GO:0010604 positive regulation of macromolecule metabolic process
173 GO:0051173 positive regulation of nitrogen compound metabolic process
173 GO:0031326 regulation of cellular biosynthetic process
173 GO:0019219 regulation of nucleobase-containing compound metabolic process
218 GO:0060255 regulation of macromolecule metabolic process
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
491 GO:0006796 phosphate-containing compound metabolic process
539 GO:0000082 G1/S transition of mitotic cell cycle
539 GO:0034645 cellular macromolecule biosynthetic process
539 GO:0090304 nucleic acid metabolic process
539 GO:0060255 regulation of macromolecule metabolic process
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
6 GO:0043232 intracellular non-membrane-bounded organelle
6 GO:0005654 nucleoplasm
73 GO:0005634 nucleus
173 GO:0005654 nucleoplasm
218 GO:0005634 nucleus
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
491 GO:0005829 cytosol
491 GO:0043232 intracellular non-membrane-bounded organelle
491 GO:0005634 nucleus
539 GO:0043232 intracellular non-membrane-bounded organelle
539 GO:0005654 nucleoplasm
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
GO:0000082 G1/S transition of mitotic cell cycle TAS
GO:0001666 response to hypoxia IEA
GO:0001890 placenta development IEA
GO:0006813 potassium ion transport IEA
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
GO:0007050 cell cycle arrest IMP
GO:0007096 regulation of exit from mitosis IEA
GO:0007219 Notch signaling pathway IEA
GO:0007605 sensory perception of sound IEA
GO:0008284 positive regulation of cell proliferation IEA
GO:0008285 negative regulation of cell proliferation IMP
GO:0009749 response to glucose IEA
GO:0010942 positive regulation of cell death IDA
GO:0030308 negative regulation of cell growth IDA
GO:0031116 positive regulation of microtubule polymerization IEA
GO:0032355 response to estradiol IEA
GO:0033673 negative regulation of kinase activity IDA
GO:0042326 negative regulation of phosphorylation IDA
GO:0042493 response to drug IEA
GO:0043066 negative regulation of apoptotic process IEA
GO:0043200 response to amino acid IEA
GO:0043434 response to peptide hormone IEA
GO:0043491 protein kinase B signaling TAS
GO:0045732 positive regulation of protein catabolic process IDA
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
GO:0045786 negative regulation of cell cycle IMP
GO:0045787 positive regulation of cell cycle TAS
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0045930 negative regulation of mitotic cell cycle IDA
GO:0046686 response to cadmium ion IEA
GO:0048102 autophagic cell death IDA
GO:0048839 inner ear development IEA
GO:0051271 negative regulation of cellular component movement IEA
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IEA
GO:0071236 cellular response to antibiotic IEA
GO:0071285 cellular response to lithium ion IDA
GO:0071407 cellular response to organic cyclic compound IEA
GO:0071850 mitotic cell cycle arrest IDA
GO:1902746 regulation of lens fiber cell differentiation IEA
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IMP
GO:1904706 negative regulation of vascular smooth muscle cell proliferation IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005768 endosome IEA
GO:0005829 cytosol TAS
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA
GO:0043231 intracellular membrane-bounded organelle IDA
GO:0043234 protein complex IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005768 endosome 4.09e-12 7.34e-15
GO:0005654 nucleoplasm GO:0005768 endosome 1.29e-11 1.85e-14
PMID Article Title
7882309 Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.
8033212 Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
8684460 Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
10323868 Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
10831586 Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.
12042314 Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
12093740 A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.
12244301 PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
12244303 Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
12972555 Spy1 interacts with p27Kip1 to allow G1/S progression.
14504289 Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization.
15280662 Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16007079 Cdc2-cyclin E complexes regulate the G1/S phase transition.
16195327 Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.
16209941 Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.
16782892 Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'.
16880511 Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.
17030811 Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans.
17254966 Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
17254967 p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
18593906 Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.
19075005 p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.
20824794 A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization.
21423214 Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.
22586611 PPM1H is a p27 phosphatase implicated in trastuzumab resistance.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23478441 Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase.
23707388 Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.
28666995 Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.
OMIM ID Disease Name
610755 Multiple endocrine neoplasia 4
Domain Name Domain ID Source
CDI IPR003175 InterPro
CDKN1B IPR029843 InterPro
CDI PF02234 Pfam
PTHR10265 PTHR10265 PANTHER
PTHR10265:SF9 PTHR10265:SF9 PANTHER