Protein: P11473

Uniprot: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0034641 cellular nitrogen compound metabolic process 35 4.22e-144 6.90e-18
Module ID (MoonGO) GO ID (BP) GO Name
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
102 GO:0044267 cellular protein metabolic process
102 GO:0031325 positive regulation of cellular metabolic process
102 GO:0010604 positive regulation of macromolecule metabolic process
102 GO:0051173 positive regulation of nitrogen compound metabolic process
102 GO:0006355 regulation of transcription, DNA-templated
102 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
220 GO:0060255 regulation of macromolecule metabolic process
357 GO:0071310 cellular response to organic substance
357 GO:0031324 negative regulation of cellular metabolic process
357 GO:0010605 negative regulation of macromolecule metabolic process
357 GO:0051172 negative regulation of nitrogen compound metabolic process
357 GO:0031325 positive regulation of cellular metabolic process
357 GO:0010604 positive regulation of macromolecule metabolic process
357 GO:0051173 positive regulation of nitrogen compound metabolic process
357 GO:0009966 regulation of signal transduction
357 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0008219 cell death
535 GO:0044267 cellular protein metabolic process
535 GO:0071495 cellular response to endogenous stimulus
535 GO:0071310 cellular response to organic substance
535 GO:0010605 negative regulation of macromolecule metabolic process
535 GO:0045893 positive regulation of transcription, DNA-templated
535 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0007165 signal transduction
559 GO:0006355 regulation of transcription, DNA-templated
605 GO:0007165 signal transduction
769 GO:0007165 signal transduction
823 GO:0044267 cellular protein metabolic process
823 GO:0071310 cellular response to organic substance
823 GO:0010629 negative regulation of gene expression
823 GO:0031325 positive regulation of cellular metabolic process
823 GO:0010628 positive regulation of gene expression
823 GO:0051173 positive regulation of nitrogen compound metabolic process
823 GO:0006357 regulation of transcription from RNA polymerase II promoter
823 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
102 GO:0005634 nucleus
169 GO:0005654 nucleoplasm
220 GO:0005634 nucleus
357 GO:0005654 nucleoplasm
535 GO:0005829 cytosol
535 GO:0043232 intracellular non-membrane-bounded organelle
535 GO:0005654 nucleoplasm
559 GO:0031981 nuclear lumen
823 GO:0005829 cytosol
823 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0000902 cell morphogenesis IMP
GO:0001501 skeletal system development IEA
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0006816 calcium ion transport IEA
GO:0006874 cellular calcium ion homeostasis IEA
GO:0007165 signal transduction TAS
GO:0007595 lactation IEA
GO:0008285 negative regulation of cell proliferation IDA
GO:0010628 positive regulation of gene expression IMP
GO:0010839 negative regulation of keratinocyte proliferation IMP
GO:0010980 positive regulation of vitamin D 24-hydroxylase activity IDA
GO:0038183 bile acid signaling pathway IDA
GO:0043401 steroid hormone mediated signaling pathway IEA
GO:0045618 positive regulation of keratinocyte differentiation IMP
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP
GO:0046697 decidualization IEP
GO:0050892 intestinal absorption IEA
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution IEA
GO:0060558 regulation of calcidiol 1-monooxygenase activity ISS
GO:0060745 mammary gland branching involved in pregnancy IEA
GO:0070561 vitamin D receptor signaling pathway IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0043235 receptor complex IDA
GO:0090575 RNA polymerase II transcription factor complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1324736 A single receptor identical with that from intestine/T47D cells mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells.
1652893 A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection.
1850412 Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing.
2177843 A unique point mutation in the human vitamin D receptor chromosomal gene confers hereditary resistance to 1,25-dihydroxyvitamin D3.
2835767 Cloning and expression of full-length cDNA encoding human vitamin D receptor.
2849209 Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets.
7828346 Two mutations causing vitamin D resistant rickets: modelling on the basis of steroid hormone receptor DNA-binding domain crystal structures.
8106618 Hereditary 1 alpha,25-dihydroxyvitamin D-resistant rickets resulting from a mutation in the vitamin D receptor deoxyribonucleic acid-binding domain.
8381803 A new point mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor in a kindred with hereditary 1,25-dihydroxyvitamin D-resistant rickets.
8392085 Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3.
8675579 A novel mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor causes hereditary 1,25-dihydroxyvitamin D-resistant rickets.
8961271 Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D(3): point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner.
9005998 Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness.
9212063 Structural organization of the human vitamin D receptor chromosomal gene and its promoter.
9267036 Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
9632709 Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription.
10678179 The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand.
10866662 A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP.
11344298 Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands.
11980721 Structural basis of VDR-DNA interactions on direct repeat response elements.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15032981 Vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms in spinal tuberculosis.
15055995 Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modification.
15225774 Structural analysis of RXR-VDR interactions on DR3 DNA.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15728261 Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.
16252006 Ligand-induced transrepression by VDR through association of WSTF with acetylated histones.
16252240 Promoter and 3'-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam study.
16541075 The finished DNA sequence of human chromosome 12.
16913708 Probing a water channel near the A-ring of receptor-bound 1 alpha,25-dihydroxyvitamin D3 with selected 2 alpha-substituted analogues.
17970811 A novel mutation in the VDR gene in hereditary vitamin D-resistant rickets.
22323358 IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.
28698609 Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia.
OMIM ID Disease Name
277440 Rickets vitamin D-dependent 2A
Domain Name Domain ID Source
A28200 A28200 PIR
VitD_rcpt IPR000324 InterPro
Nucl_hrmn_rcpt_lig-bd IPR000536 InterPro
Znf_hrmn_rcpt IPR001628 InterPro
Nuclear_hrmn_rcpt IPR001723 InterPro
Znf_NHR/GATA IPR013088 InterPro
NHR_like_dom_sf IPR035500 InterPro
Hormone_recep PF00104 Pfam
zf-C4 PF00105 Pfam
STROIDFINGER PR00047 PRINTS
VITAMINDR PR00350 PRINTS
STRDHORMONER PR00398 PRINTS
NUCLEAR_REC_DBD_1 PS00031 PROSITE
NUCLEAR_REC_DBD_2 PS51030 PROSITE
NR_LBD PS51843 PROSITE
ZnF_C4 SM00399 SMART
HOLI SM00430 SMART
SSF48508 SSF48508 SUPFAM