Protein: P60520

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P60520 (Uniprot) GBRL2_HUMAN GABARAPL2 Gamma-aminobutyric acid receptor-associated protein-like 2 human No
Uniprot: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0033036 macromolecule localization 517 GO:0009059 macromolecule biosynthetic process 62 2.32e-08 6.09e-30
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
62 GO:0034645 cellular macromolecule biosynthetic process
62 GO:0090304 nucleic acid metabolic process
62 GO:1901362 organic cyclic compound biosynthetic process
62 GO:0060255 regulation of macromolecule metabolic process
404 GO:0044267 cellular protein metabolic process
404 GO:0007165 signal transduction
517 GO:0008104 protein localization
517 GO:0019538 protein metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
62 GO:0005829 cytosol
62 GO:0005634 nucleus
404 GO:0005829 cytosol
404 GO:0012505 endomembrane system
404 GO:0031982 vesicle
517 GO:0005829 cytosol
517 GO:0012505 endomembrane system
517 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000045 autophagosome assembly IBA
GO:0000422 autophagy of mitochondrion IBA
GO:0006891 intra-Golgi vesicle-mediated transport ISS
GO:0006914 autophagy NAS
GO:0006995 cellular response to nitrogen starvation IBA
GO:0015031 protein transport IEA
GO:0016236 macroautophagy TAS
GO:0032781 positive regulation of ATPase activity ISS
GO:0097352 autophagosome maturation TAS
GO:1901799 negative regulation of proteasomal protein catabolic process IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000139 Golgi membrane IDA
GO:0000421 autophagosome membrane TAS
GO:0005622 intracellular IDA
GO:0005737 cytoplasm IDA
GO:0005776 autophagosome IDA
GO:0005794 Golgi apparatus ISS
GO:0005829 cytosol TAS
GO:0031410 cytoplasmic vesicle IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
11096062 The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.
11146101 Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.
11414770 Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.
11825910 Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
12507496 GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15169837 LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17580304 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
19056683 The TP53INP2 protein is required for autophagy in mammalian cells.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20418806 LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis.
20562859 Network organization of the human autophagy system.
21269460 Initial characterization of the human central proteome.
21383079 OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.
22311637 Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens.
22354992 Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
22421968 TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.
22470510 DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.
23043107 ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.
23209295 Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis.
24089205 Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.
24668264 Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.
25127057 TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
26347139 TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
No results found.
Domain Name Domain ID Source
Atg8-like IPR004241 InterPro
Ubiquitin-like_domsf IPR029071 InterPro
Atg8 PF02991 Pfam
PTHR10969 PTHR10969 PANTHER
SSF54236 SSF54236 SUPFAM
GABARAP cd01611 CDD