Protein: Q9C0C9

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9C0C9 (Uniprot) UBE2O_HUMAN UBE2O (E3-independent) E2 ubiquitin-conjugating enzyme human No
Uniprot: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006725 cellular aromatic compound metabolic process 53 GO:0007165 signal transduction 831 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
238 GO:0060255 regulation of macromolecule metabolic process
656 GO:0016070 RNA metabolic process
656 GO:0034645 cellular macromolecule biosynthetic process
656 GO:0044271 cellular nitrogen compound biosynthetic process
656 GO:0010467 gene expression
656 GO:0060255 regulation of macromolecule metabolic process
780 GO:0006355 regulation of transcription, DNA-templated
831 GO:0007166 cell surface receptor signaling pathway
831 GO:0044271 cellular nitrogen compound biosynthetic process
831 GO:0006139 nucleobase-containing compound metabolic process
831 GO:0006796 phosphate-containing compound metabolic process
831 GO:0010646 regulation of cell communication
831 GO:0060255 regulation of macromolecule metabolic process
831 GO:0023051 regulation of signaling
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
238 GO:0005829 cytosol
238 GO:0005634 nucleus
656 GO:0043232 intracellular non-membrane-bounded organelle
656 GO:0005634 nucleus
780 GO:0005654 nucleoplasm
831 GO:0042995 cell projection
831 GO:0005829 cytosol
831 GO:0005634 nucleus
831 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006513 protein monoubiquitination IDA
GO:0030513 positive regulation of BMP signaling pathway IDA
GO:0042147 retrograde transport, endosome to Golgi IMP
GO:0070534 protein K63-linked ubiquitination IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol IEA
GO:0016604 nuclear body IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
11214970 Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
11311559 Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17974005 The full-ORF clone resource of the German cDNA consortium.
18220336 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23381138 UBE2O negatively regulates TRAF6-mediated NF-kappaB activation by inhibiting TRAF6 polyubiquitination.
23452853 Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.
23455153 Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24703950 Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.
No results found.
Domain Name Domain ID Source
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD