Protein: Q9UKG1 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9UKG1 (Uniprot)	DP13A_HUMAN	APPL1	DCC-interacting protein 13-alpha	human	Yes

Protein Function

Uniprot: Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor more..

Dissimilar Functions Manual Curation

Function 1: Endocytic function. Links Rab5 to nuclear signal transduction. Condition: cytoplasm localisation.

Function 2: Nucleosome remodelling, transcription regulation. Condition: nuclear localisation.

Publications (PMID): 15016378, 15261672, 19686092, 19433865

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0010646	regulation of cell communication	284	GO:0006725	cellular aromatic compound metabolic process	53	4.64e-30	1.07e-07

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
53	GO:0006139	nucleobase-containing compound metabolic process
53	GO:0016567	protein ubiquitination
53	GO:0060255	regulation of macromolecule metabolic process
284	GO:0009966	regulation of signal transduction
655	GO:0006464	cellular protein modification process
655	GO:0071310	cellular response to organic substance
655	GO:0035556	intracellular signal transduction
655	GO:0031325	positive regulation of cellular metabolic process
655	GO:0010604	positive regulation of macromolecule metabolic process
655	GO:0051173	positive regulation of nitrogen compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
43	GO:0005634	nucleus
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
227	GO:0005634	nucleus
284	GO:0005829	cytosol
284	GO:0005886	plasma membrane
651	GO:0005829	cytosol
655	GO:0005829	cytosol
655	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007049	cell cycle	IEA
GO:0007165	signal transduction	TAS
GO:0008283	cell proliferation	IDA
GO:0008286	insulin receptor signaling pathway	IMP
GO:0046324	regulation of glucose import	IMP
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	TAS
GO:1903076	regulation of protein localization to plasma membrane	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IC
GO:0005769	early endosome	ISS
GO:0005829	cytosol	IDA
GO:0010008	endosome membrane	TAS
GO:0012506	vesicle membrane	IDA
GO:0016581	NuRD complex	IDA
GO:0031901	early endosome membrane	IEA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0010008	endosome membrane	1.38e-08	8.40e-30
GO:0005634	nucleus	GO:0012506	vesicle membrane	9.35e-29	3.51e-48
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ACTN2_HUMAN	No
AKT1_HUMAN	No
AKT2_HUMAN	No
ANKR1_HUMAN	No
ASPP2_HUMAN	No
AT2A1_HUMAN	No
BATF3_HUMAN	No
BIN1_HUMAN	Yes: O00499 (MoonDB)
BRWD1_HUMAN	No
C1T9A_HUMAN	No

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Publications Associated

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PMID	Article Title
10490823	Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
10718198	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
12011067	Mediation of the DCC apoptotic signal by DIP13 alpha.
12168954	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
15016378	APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16959974	The consensus coding sequences of human breast and colorectal cancers.
17525332	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17765681	A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.
18669648	A quantitative atlas of mitotic phosphorylation.

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OMIM Diseases Associated

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OMIM ID	Disease Name
616511	Maturity-onset diabetes of the young 14

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Protein Domains Associated

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Domain Name	Domain ID	Source
AH/BAR_dom_sf	IPR027267	InterPro
APPL1_BAR	IPR037929	InterPro
BAR_APPL1	cd07631	CDD
PH	PF00169	Pfam
PH	SM00233	SMART
PH-like_dom_sf	IPR011993	InterPro
PH_domain	IPR001849	InterPro
PH_DOMAIN	PS50003	PROSITE
PID	PF00640	Pfam
PID	PS01179	PROSITE

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