Protein: P50570

Uniprot: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). more..

Function 1: GTPase involved in membrane scission, remodelling and cytokinesis.

Function 2: Mitosis, centromere cohesion. Condition: interaction with microtubules, located at the mitotic spindle.

Publications (PMID): 15048127

Module ID (MoonGO) GO ID (BP) GO Name
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
284 GO:0009966 regulation of signal transduction
305 GO:0060255 regulation of macromolecule metabolic process
450 GO:0051252 regulation of RNA metabolic process
450 GO:0010646 regulation of cell communication
450 GO:2000112 regulation of cellular macromolecule biosynthetic process
450 GO:0010468 regulation of gene expression
450 GO:0023051 regulation of signaling
450 GO:0007165 signal transduction
682 GO:0034645 cellular macromolecule biosynthetic process
682 GO:0006464 cellular protein modification process
682 GO:0035556 intracellular signal transduction
682 GO:0090304 nucleic acid metabolic process
682 GO:0010468 regulation of gene expression
682 GO:0019219 regulation of nucleobase-containing compound metabolic process
684 GO:0022402 cell cycle process
684 GO:0051640 organelle localization
Module ID (MoonGO) GO ID (CC) GO Name
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
305 GO:0005634 nucleus
450 GO:0005634 nucleus
682 GO:0005634 nucleus
684 GO:0005829 cytosol
684 GO:0005815 microtubule organizing center
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000086 G2/M transition of mitotic cell cycle NAS
GO:0000266 mitochondrial fission IBA
GO:0002031 G-protein coupled receptor internalization IEA
GO:0003281 ventricular septum development IEA
GO:0003374 dynamin family protein polymerization involved in mitochondrial fission IBA
GO:0006355 regulation of transcription, DNA-templated NAS
GO:0006893 Golgi to plasma membrane transport IEA
GO:0006897 endocytosis NAS
GO:0006898 receptor-mediated endocytosis ISS
GO:0006909 phagocytosis IEA
GO:0007165 signal transduction NAS
GO:0007283 spermatogenesis IEA
GO:0009416 response to light stimulus IEA
GO:0010592 positive regulation of lamellipodium assembly IEA
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
GO:0030516 regulation of axon extension ISS
GO:0031623 receptor internalization IMP
GO:0033572 transferrin transport IMP
GO:0035020 regulation of Rac protein signal transduction IEA
GO:0035904 aorta development IEA
GO:0042220 response to cocaine IEA
GO:0043065 positive regulation of apoptotic process NAS
GO:0044351 macropinocytosis IEA
GO:0045429 positive regulation of nitric oxide biosynthetic process IEA
GO:0045893 positive regulation of transcription, DNA-templated NAS
GO:0048489 synaptic vesicle transport NAS
GO:0048812 neuron projection morphogenesis ISS
GO:0050766 positive regulation of phagocytosis IEA
GO:0050999 regulation of nitric-oxide synthase activity TAS
GO:0060976 coronary vasculature development IEA
GO:0061024 membrane organization TAS
GO:0061025 membrane fusion IBA
GO:0071245 cellular response to carbon monoxide IEA
GO:0071481 cellular response to X-ray IEA
GO:0071732 cellular response to nitric oxide IEA
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
GO:1902856 negative regulation of non-motile cilium assembly IEA
GO:1903351 cellular response to dopamine IEA
GO:1903358 regulation of Golgi organization IEA
GO:1903408 positive regulation of sodium:potassium-exchanging ATPase activity IEA
GO:1903526 negative regulation of membrane tubulation IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000139 Golgi membrane TAS
GO:0001891 phagocytic cup IEA
GO:0001917 photoreceptor inner segment IEA
GO:0005634 nucleus IEA
GO:0005768 endosome IEA
GO:0005794 Golgi apparatus IDA
GO:0005802 trans-Golgi network IEA
GO:0005813 centrosome IEA
GO:0005829 cytosol TAS
GO:0005874 microtubule IDA
GO:0005886 plasma membrane TAS
GO:0005905 clathrin-coated pit ISS
GO:0005925 focal adhesion IDA
GO:0014069 postsynaptic density IEA
GO:0030027 lamellipodium IEA
GO:0030426 growth cone ISS
GO:0030496 midbody IEA
GO:0030666 endocytic vesicle membrane TAS
GO:0030670 phagocytic vesicle membrane IEA
GO:0031966 mitochondrial membrane IBA
GO:0032587 ruffle membrane IEA
GO:0043234 protein complex IEA
GO:0045211 postsynaptic membrane IDA
GO:0045334 clathrin-coated endocytic vesicle IEA
GO:0048471 perinuclear region of cytoplasm IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000139 Golgi membrane GO:0005634 nucleus 1.09e-30 1.17e-81
GO:0005634 nucleus GO:0005768 endosome 4.09e-12 7.34e-15
GO:0005634 nucleus GO:0005794 Golgi apparatus 4.39e-25 2.14e-64
GO:0005634 nucleus GO:0005802 trans-Golgi network 6.33e-05 3.57e-57
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0030666 endocytic vesicle membrane 1.59e-05 7.63e-18
GO:0005634 nucleus GO:0031966 mitochondrial membrane 7.12e-06 7.29e-05
GO:0005634 nucleus GO:0045211 postsynaptic membrane 4.18e-05 1.09e-18
GO:0005634 nucleus GO:0045334 clathrin-coated endocytic vesicle 6.29e-03 1.54e-23
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005813 centrosome GO:0005886 plasma membrane 6.39e-08 8.47e-54
PMID Article Title
7590285 Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family.
11583995 Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton.
12498685 The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057824 The DNA sequence and biology of human chromosome 19.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15703209 SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.
15731758 Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease.
16227997 Mutations in dynamin 2 cause dominant centronuclear myopathy.
16234328 NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS.
16325581 TTP specifically regulates the internalization of the transferrin receptor.
17257598 Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis.
17636067 Two novel mutations in dynamin-2 cause axonal Charcot-Marie-Tooth disease.
17825552 Subtle central and peripheral nervous system abnormalities in a family with centronuclear myopathy and a novel dynamin 2 gene mutation.
17932957 Dynamin 2 mutations cause sporadic centronuclear myopathy with neonatal onset.
18353773 A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
18480402 The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.
18560793 Magnetic resonance imaging findings of leg musculature in Charcot-Marie-Tooth disease type 2 due to dynamin 2 mutation.
18669648 A quantitative atlas of mitotic phosphorylation.
19122038 A new centronuclear myopathy phenotype due to a novel dynamin 2 mutation.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19623537 Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19932619 Adult course in dynamin 2 dominant centronuclear myopathy with neonatal onset.
19932620 Centronuclear myopathy with cataracts due to a novel dynamin 2 (DNM2) mutation.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20227276 Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy.
21269460 Initial characterization of the human central proteome.
22022388 Identification of novel NPRAP/delta-catenin-interacting proteins and the direct association of NPRAP with dynamin 2.
22396310 Mutation spectrum in the large GTPase dynamin 2, and genotype-phenotype correlation in autosomal dominant centronuclear myopathy.
23092955 Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
OMIM ID Disease Name
160150 Myopathy, centronuclear, 1
606482 Charcot-Marie-Tooth disease 2M
606482 Charcot-Marie-Tooth disease, dominant, intermediate type, B
615368 Lethal congenital contracture syndrome 5
Domain Name Domain ID Source
Dynamin_central IPR000375 InterPro
Dynamin_GTPase IPR001401 InterPro
PH_domain IPR001849 InterPro
GED IPR003130 InterPro
PH-like_dom_sf IPR011993 InterPro
Dynamin_GTPase_CS IPR019762 InterPro
GED_dom IPR020850 InterPro
Dynamin_SF IPR022812 InterPro
DNM2 IPR027188 InterPro
P-loop_NTPase IPR027417 InterPro
G_DYNAMIN_dom IPR030381 InterPro
JC4305 JC4305 PIR
PH PF00169 Pfam
Dynamin_N PF00350 Pfam
Dynamin_M PF01031 Pfam
GED PF02212 Pfam
SSF52540 SSF52540 SUPFAM
DLP_1 cd08771 CDD