Protein: P46108

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P46108 (Uniprot) CRK_HUMAN CRK Adapter molecule crk human No
Uniprot: Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0043170 macromolecule metabolic process 20, 367 GO:0022610 biological adhesion 869 2.68e-16 4.92e-03
GO:0034641 cellular nitrogen compound metabolic process 35, 327 GO:0007165 signal transduction 355, 486 4.22e-144 6.90e-18
GO:0034641 cellular nitrogen compound metabolic process 35, 327 GO:0006928 movement of cell or subcellular component 496 7.55e-40 5.63e-168
GO:0034641 cellular nitrogen compound metabolic process 35, 327 GO:0022610 biological adhesion 869 6.87e-63 4.34e-65
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 327 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0006725 cellular aromatic compound metabolic process 494 3.09e-47 2.24e-87
GO:0007166 cell surface receptor signaling pathway 108 GO:0009059 macromolecule biosynthetic process 682 2.49e-18 9.18e-29
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 860 6.88e-41 1.21e-84
GO:0007165 signal transduction 141, 187, 355, 486 GO:0006725 cellular aromatic compound metabolic process 494 5.44e-126 5.27e-27
GO:0007165 signal transduction 141, 187, 355, 486 GO:0006139 nucleobase-containing compound metabolic process 860 1.10e-111 5.07e-25
GO:0010646 regulation of cell communication 284 GO:0034641 cellular nitrogen compound metabolic process 35, 327 1.59e-39 2.52e-03
GO:0010646 regulation of cell communication 284 GO:0006725 cellular aromatic compound metabolic process 494 4.64e-30 1.07e-07
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 860 6.71e-28 7.52e-07
GO:0006725 cellular aromatic compound metabolic process 494 GO:0006928 movement of cell or subcellular component 496 1.24e-32 2.63e-196
GO:0006725 cellular aromatic compound metabolic process 494 GO:0022610 biological adhesion 869 6.51e-58 2.68e-107
GO:0006928 movement of cell or subcellular component 496 GO:0006139 nucleobase-containing compound metabolic process 860 1.95e-31 6.36e-195
GO:0044260 cellular macromolecule metabolic process 589 GO:0022610 biological adhesion 869 6.74e-23 3.02e-10
GO:0009059 macromolecule biosynthetic process 682 GO:0022610 biological adhesion 869 2.22e-23 6.08e-57
GO:0006139 nucleobase-containing compound metabolic process 860 GO:0022610 biological adhesion 869 2.30e-55 4.36e-110
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
20 GO:0019538 protein metabolic process
20 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
40 GO:0051276 chromosome organization
40 GO:0090304 nucleic acid metabolic process
40 GO:0060255 regulation of macromolecule metabolic process
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
141 GO:0035556 intracellular signal transduction
141 GO:0006468 protein phosphorylation
141 GO:0060255 regulation of macromolecule metabolic process
166 GO:0044267 cellular protein metabolic process
166 GO:0006139 nucleobase-containing compound metabolic process
166 GO:0060255 regulation of macromolecule metabolic process
166 GO:0007165 signal transduction
171 GO:0006464 cellular protein modification process
171 GO:0035556 intracellular signal transduction
171 GO:0009966 regulation of signal transduction
177 GO:0044267 cellular protein metabolic process
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
205 GO:0071310 cellular response to organic substance
205 GO:0007167 enzyme linked receptor protein signaling pathway
205 GO:0090304 nucleic acid metabolic process
205 GO:0034654 nucleobase-containing compound biosynthetic process
205 GO:0043085 positive regulation of catalytic activity
205 GO:0031325 positive regulation of cellular metabolic process
205 GO:0010604 positive regulation of macromolecule metabolic process
205 GO:0051173 positive regulation of nitrogen compound metabolic process
205 GO:0009967 positive regulation of signal transduction
205 GO:0006468 protein phosphorylation
205 GO:2000112 regulation of cellular macromolecule biosynthetic process
205 GO:0032268 regulation of cellular protein metabolic process
205 GO:0010468 regulation of gene expression
205 GO:1902531 regulation of intracellular signal transduction
205 GO:0019219 regulation of nucleobase-containing compound metabolic process
205 GO:0042325 regulation of phosphorylation
205 GO:0051049 regulation of transport
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
254 GO:0044267 cellular protein metabolic process
254 GO:0048584 positive regulation of response to stimulus
254 GO:0010468 regulation of gene expression
254 GO:0007165 signal transduction
274 GO:0007165 signal transduction
284 GO:0009966 regulation of signal transduction
287 GO:0006464 cellular protein modification process
287 GO:0006355 regulation of transcription, DNA-templated
306 GO:0044267 cellular protein metabolic process
306 GO:0060255 regulation of macromolecule metabolic process
306 GO:0007165 signal transduction
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
367 GO:0010467 gene expression
367 GO:0007399 nervous system development
367 GO:0006139 nucleobase-containing compound metabolic process
367 GO:0019538 protein metabolic process
367 GO:0051128 regulation of cellular component organization
367 GO:0060255 regulation of macromolecule metabolic process
367 GO:0007165 signal transduction
377 GO:0007165 signal transduction
419 GO:0022607 cellular component assembly
423 GO:0006464 cellular protein modification process
423 GO:0090304 nucleic acid metabolic process
423 GO:0060255 regulation of macromolecule metabolic process
435 GO:0031325 positive regulation of cellular metabolic process
435 GO:0010604 positive regulation of macromolecule metabolic process
435 GO:0051173 positive regulation of nitrogen compound metabolic process
435 GO:0019538 protein metabolic process
435 GO:0006357 regulation of transcription from RNA polymerase II promoter
435 GO:0007165 signal transduction
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
482 GO:0006464 cellular protein modification process
482 GO:0007167 enzyme linked receptor protein signaling pathway
482 GO:0006796 phosphate-containing compound metabolic process
482 GO:0032268 regulation of cellular protein metabolic process
482 GO:0009966 regulation of signal transduction
486 GO:0007166 cell surface receptor signaling pathway
486 GO:0006464 cellular protein modification process
486 GO:0060255 regulation of macromolecule metabolic process
494 GO:0006139 nucleobase-containing compound metabolic process
496 GO:0048870 cell motility
496 GO:0071310 cellular response to organic substance
496 GO:0090304 nucleic acid metabolic process
496 GO:0034654 nucleobase-containing compound biosynthetic process
496 GO:0043085 positive regulation of catalytic activity
496 GO:0031325 positive regulation of cellular metabolic process
496 GO:1902533 positive regulation of intracellular signal transduction
496 GO:0010604 positive regulation of macromolecule metabolic process
496 GO:0051173 positive regulation of nitrogen compound metabolic process
496 GO:0051128 regulation of cellular component organization
496 GO:2000112 regulation of cellular macromolecule biosynthetic process
496 GO:0010468 regulation of gene expression
496 GO:0043549 regulation of kinase activity
496 GO:0019219 regulation of nucleobase-containing compound metabolic process
496 GO:0001932 regulation of protein phosphorylation
496 GO:0009719 response to endogenous stimulus
496 GO:1901700 response to oxygen-containing compound
496 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
514 GO:0044267 cellular protein metabolic process
514 GO:0071310 cellular response to organic substance
514 GO:0033554 cellular response to stress
514 GO:0035556 intracellular signal transduction
514 GO:0031328 positive regulation of cellular biosynthetic process
514 GO:0010557 positive regulation of macromolecule biosynthetic process
514 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
514 GO:0042981 regulation of apoptotic process
514 GO:0010646 regulation of cell communication
514 GO:0023051 regulation of signaling
514 GO:0006357 regulation of transcription from RNA polymerase II promoter
563 GO:0044267 cellular protein metabolic process
563 GO:0006139 nucleobase-containing compound metabolic process
563 GO:0010646 regulation of cell communication
563 GO:0060255 regulation of macromolecule metabolic process
563 GO:0023051 regulation of signaling
563 GO:0007165 signal transduction
589 GO:0016070 RNA metabolic process
589 GO:0010467 gene expression
589 GO:0031325 positive regulation of cellular metabolic process
589 GO:2000112 regulation of cellular macromolecule biosynthetic process
589 GO:0019219 regulation of nucleobase-containing compound metabolic process
590 GO:0048468 cell development
590 GO:0007166 cell surface receptor signaling pathway
590 GO:0022607 cellular component assembly
590 GO:0032989 cellular component morphogenesis
590 GO:0006464 cellular protein modification process
590 GO:0006928 movement of cell or subcellular component
590 GO:0030182 neuron differentiation
590 GO:0120036 plasma membrane bounded cell projection organization
590 GO:0010628 positive regulation of gene expression
590 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
590 GO:0051128 regulation of cellular component organization
590 GO:0042325 regulation of phosphorylation
590 GO:0051246 regulation of protein metabolic process
590 GO:0006357 regulation of transcription from RNA polymerase II promoter
682 GO:0034645 cellular macromolecule biosynthetic process
682 GO:0006464 cellular protein modification process
682 GO:0035556 intracellular signal transduction
682 GO:0090304 nucleic acid metabolic process
682 GO:0010468 regulation of gene expression
682 GO:0019219 regulation of nucleobase-containing compound metabolic process
688 GO:0006355 regulation of transcription, DNA-templated
688 GO:0007165 signal transduction
732 GO:0006355 regulation of transcription, DNA-templated
860 GO:0090304 nucleic acid metabolic process
860 GO:0034654 nucleobase-containing compound biosynthetic process
860 GO:2000112 regulation of cellular macromolecule biosynthetic process
860 GO:0019219 regulation of nucleobase-containing compound metabolic process
869 GO:0007155 cell adhesion
869 GO:0048468 cell development
869 GO:0016477 cell migration
869 GO:0000902 cell morphogenesis
869 GO:0044255 cellular lipid metabolic process
869 GO:0071363 cellular response to growth factor stimulus
869 GO:0072359 circulatory system development
869 GO:0009059 macromolecule biosynthetic process
869 GO:0022008 neurogenesis
869 GO:0019637 organophosphate metabolic process
869 GO:0018108 peptidyl-tyrosine phosphorylation
869 GO:0120036 plasma membrane bounded cell projection organization
869 GO:1902533 positive regulation of intracellular signal transduction
869 GO:0045860 positive regulation of protein kinase activity
869 GO:0043408 regulation of MAPK cascade
869 GO:2000145 regulation of cell motility
869 GO:0042127 regulation of cell proliferation
869 GO:0010468 regulation of gene expression
869 GO:2000026 regulation of multicellular organismal development
869 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
20 GO:0005886 plasma membrane
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
40 GO:0043232 intracellular non-membrane-bounded organelle
40 GO:0005654 nucleoplasm
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
141 GO:0005634 nucleus
166 GO:0005829 cytosol
166 GO:0070013 intracellular organelle lumen
166 GO:0044428 nuclear part
166 GO:0005886 plasma membrane
171 GO:0005829 cytosol
171 GO:0005886 plasma membrane
177 GO:0005634 nucleus
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
205 GO:0005829 cytosol
205 GO:0005634 nucleus
205 GO:0005886 plasma membrane
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
254 GO:0005829 cytosol
254 GO:0005634 nucleus
274 GO:0005829 cytosol
274 GO:0012505 endomembrane system
274 GO:0031982 vesicle
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
287 GO:0005829 cytosol
287 GO:0043232 intracellular non-membrane-bounded organelle
287 GO:0031981 nuclear lumen
306 GO:0070062 extracellular exosome
317 GO:0005829 cytosol
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
355 GO:0044459 plasma membrane part
367 GO:0005829 cytosol
367 GO:0070013 intracellular organelle lumen
367 GO:0005634 nucleus
377 GO:0005634 nucleus
417 GO:0005829 cytosol
417 GO:0043232 intracellular non-membrane-bounded organelle
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
423 GO:0005829 cytosol
423 GO:0005634 nucleus
435 GO:0005654 nucleoplasm
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
482 GO:0005576 extracellular region
486 GO:0005829 cytosol
486 GO:0005634 nucleus
486 GO:0031982 vesicle
488 GO:0005634 nucleus
488 GO:0031982 vesicle
494 GO:0005634 nucleus
496 GO:0005829 cytosol
496 GO:0005634 nucleus
496 GO:0005886 plasma membrane
514 GO:0005654 nucleoplasm
563 GO:0005634 nucleus
589 GO:0005829 cytosol
589 GO:0005634 nucleus
590 GO:0005829 cytosol
590 GO:0005634 nucleus
590 GO:0005886 plasma membrane
651 GO:0005829 cytosol
682 GO:0005634 nucleus
688 GO:0005634 nucleus
732 GO:0043232 intracellular non-membrane-bounded organelle
732 GO:0031981 nuclear lumen
860 GO:0043232 intracellular non-membrane-bounded organelle
860 GO:0005634 nucleus
869 GO:0012505 endomembrane system
869 GO:0005615 extracellular space
869 GO:0044459 plasma membrane part
869 GO:0031982 vesicle
875 GO:0005856 cytoskeleton
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000186 activation of MAPKK activity TAS
GO:0001878 response to yeast IEA
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS
GO:0008360 regulation of cell shape IMP
GO:0009966 regulation of signal transduction IDA
GO:0014911 positive regulation of smooth muscle cell migration IEA
GO:0032956 regulation of actin cytoskeleton organization IDA
GO:0035020 regulation of Rac protein signal transduction IEA
GO:0035728 response to hepatocyte growth factor IEA
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0042542 response to hydrogen peroxide IEA
GO:0043087 regulation of GTPase activity IDA
GO:0043393 regulation of protein binding IMP
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity IEA
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0048013 ephrin receptor signaling pathway IDA
GO:0061045 negative regulation of wound healing IMP
GO:0061847 response to cholecystokinin IEA
GO:0071538 SH2 domain-mediated complex assembly IDA
GO:0071560 cellular response to transforming growth factor beta stimulus IEA
GO:0071732 cellular response to nitric oxide IEA
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
GO:1990090 cellular response to nerve growth factor stimulus IEA
GO:1990314 cellular response to insulin-like growth factor stimulus IEA
GO:1990859 cellular response to endothelin IEA
GO:2000146 negative regulation of cell motility IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus TAS
GO:0005737 cytoplasm IC
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IEA
GO:0015629 actin cytoskeleton IEA
GO:0043234 protein complex IPI
GO:0045121 membrane raft IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
Interactor Also a MoonDB EMF protein
ASPP2_HUMAN No
IKZF3_HUMAN No
NUFP2_HUMAN No
BEX5_HUMAN No
ATX1_HUMAN Yes: P54253 (MoonDB)
P55G_HUMAN Yes: Q92569 (MoonDB)
CEP19_HUMAN Yes: Q96LK0 (MoonDB)
PP1A_HUMAN Yes: P62136 (MoonDB)
LASP1_HUMAN No
ESTD_HUMAN No
TNFL6_HUMAN No
TRI39_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
ODFP2_HUMAN No
CE128_HUMAN Yes: Q6ZU80 (MoonDB)
CEP89_HUMAN No
TMG2_HUMAN No
FSTL1_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
PLS1_HUMAN No
SUV92_HUMAN No
VAC14_HUMAN No
STA5A_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
P53_HUMAN Yes: P04637 (MoonDB)
PNMA2_HUMAN No
AIRE_HUMAN No
GPIX_HUMAN No
FLNA_HUMAN Yes: P21333 (MoonDB)
SAXO1_HUMAN No
DLGP2_HUMAN No
POTE1_HUMAN Yes: Q9NUX5 (MoonDB)
MYLIP_HUMAN No
CBLC_HUMAN No
PRS10_HUMAN No
RAG1_HUMAN No
RGS20_HUMAN No
FAK1_HUMAN No
SHC1_HUMAN No
BUB1_HUMAN No
PRIC3_HUMAN No
RIN3_HUMAN Yes: Q8TB24 (MoonDB)
ABL1_HUMAN Yes: P00519 (MoonDB)
PAR3_HUMAN No
SRC_HUMAN Yes: P12931 (MoonDB)
3MG_HUMAN No
ABL2_HUMAN Yes: P42684 (MoonDB)
AFF2_HUMAN No
AKAP2_HUMAN No
AKAP6_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
ANKZ1_HUMAN No
ANLN_HUMAN No
APOL5_HUMAN No
ARHGB_HUMAN No
ASAP1_HUMAN No
ASAP2_HUMAN No
ASB9_HUMAN No
ASCL4_HUMAN No
ATF3_HUMAN No
BACD1_HUMAN No
BATF3_HUMAN No
BICRA_HUMAN No
BMX_HUMAN No
BRD4_HUMAN No
C1QR1_HUMAN No
CAD11_HUMAN No
CBLB_HUMAN No
CBL_HUMAN No
CD017_HUMAN No
CELR2_HUMAN No
CF141_HUMAN No
CLNK_HUMAN No
CNDP2_HUMAN No
CNTFR_HUMAN No
CNTP1_HUMAN No
CORO6_HUMAN No
CP110_HUMAN No
CSMD2_HUMAN No
CTF18_HUMAN No
DDX41_HUMAN No
DKKL1_HUMAN No
DLGP1_HUMAN No
DLGP3_HUMAN No
DLGP4_HUMAN No
DLX4_HUMAN No
DNLI3_HUMAN No
DOCK1_HUMAN No
DOCK3_HUMAN No
DOK2_HUMAN No
DOK3_HUMAN No
DOK7_HUMAN No
DPPA4_HUMAN No
DTX1_HUMAN No
DUS15_HUMAN No
DYN2_HUMAN Yes: P50570 (MoonDB)
E41L3_HUMAN No
EFS_HUMAN No
ELK1_HUMAN No
EPS15_HUMAN Yes: P42566 (MoonDB)
EPYC_HUMAN No
ERBB3_HUMAN Yes: P21860 (MoonDB)
EXTL3_HUMAN No
EYA3_HUMAN No
FANCA_HUMAN Yes: O15360 (MoonDB)
FASTK_HUMAN No
FCG2B_HUMAN No
FCG2C_HUMAN No
FER_HUMAN No
FGFR1_HUMAN No
FLNB_HUMAN No
FLNC_HUMAN No
GAB1_HUMAN Yes: Q13480 (MoonDB)
GABP2_HUMAN No
GABR1_HUMAN No
GABT_HUMAN No
GARE1_HUMAN No
GCFC2_HUMAN No
GHR_HUMAN No
GRIP2_HUMAN No
HABP4_HUMAN No
HEXA_HUMAN No
HNRPR_HUMAN No
HSH2D_HUMAN No
I20L2_HUMAN No
ICAL_HUMAN No
ID4_HUMAN No
IF140_HUMAN No
IGF1R_HUMAN No
IN80E_HUMAN No
INSR_HUMAN No
ISL1_HUMAN No
KAPCA_HUMAN No
KCD17_HUMAN No
KIF22_HUMAN No
KIT_HUMAN No
KLF15_HUMAN No
KLH20_HUMAN No
KMT2B_HUMAN No
LHX8_HUMAN No
LIPB2_HUMAN No
LNX2_HUMAN Yes: Q8N448 (MoonDB)
M4K1_HUMAN No
MAGC3_HUMAN No
MEPE_HUMAN No
MET_HUMAN No
MIME_HUMAN No
MINT_HUMAN No
MK04_HUMAN No
MK08_HUMAN No
MNDA_HUMAN No
MY18B_HUMAN No
MYOZ2_HUMAN No
NFASC_HUMAN No
NKX21_HUMAN No
NMDE4_HUMAN No
NXPH3_HUMAN No
OFCC1_HUMAN No
OPT_HUMAN No
P85A_HUMAN Yes: P27986 (MoonDB)
P85B_HUMAN No
PA1B2_HUMAN No
PAX7_HUMAN No
PCDA1_HUMAN No
PCDA2_HUMAN No
PCDA3_HUMAN No
PCDA5_HUMAN No
PCDA6_HUMAN No
PCDA7_HUMAN No
PCDA8_HUMAN No
PCDA9_HUMAN No
PCDAA_HUMAN No
PCDAB_HUMAN No
PCDAC_HUMAN No
PDIA2_HUMAN No
PGFRA_HUMAN No
PHAR2_HUMAN No
PHC2_HUMAN Yes: Q8IXK0 (MoonDB)
PLCD_HUMAN No
PRAX_HUMAN No
PRC2B_HUMAN No
PRS4_HUMAN No
PTN4_HUMAN No
PTTG1_HUMAN No
Q9BS75_HUMAN No
RAB2B_HUMAN No
RET_HUMAN No
RGS7_HUMAN No
RPGF1_HUMAN No
RPP38_HUMAN No
RRAS_HUMAN No
RTCB_HUMAN No
RYBP_HUMAN No
SEM4D_HUMAN No
SEPT6_HUMAN No
SETD9_HUMAN No
SH22A_HUMAN Yes: Q9NP31 (MoonDB)
SHAN2_HUMAN No
SHAN3_HUMAN No
SNX17_HUMAN No
SNX3_HUMAN No
SNX7_HUMAN No
SOCS1_HUMAN No
SOCS6_HUMAN No
SOS1_HUMAN No
SOS2_HUMAN No
SP1_HUMAN No
SPR2A_HUMAN No
STAT4_HUMAN No
STF1_HUMAN No
STRN4_HUMAN No
T4S19_HUMAN No
TAL1_HUMAN No
TBA1C_HUMAN No
TDG_HUMAN No
TE2IP_HUMAN No
TELT_HUMAN No
TGON2_HUMAN No
THOC2_HUMAN No
TPX2_HUMAN No
TRI15_HUMAN Yes: Q9C019 (MoonDB)
TWST2_HUMAN No
TXK_HUMAN No
UBP53_HUMAN No
VGFR1_HUMAN No
VGFR2_HUMAN No
WDR83_HUMAN No
XPO1_HUMAN No
ZKSC7_HUMAN No
ZN557_HUMAN No
PMID Article Title
1630456 Two species of human CRK cDNA encode proteins with distinct biological activities.
8378094 CRK proto-oncogene maps to human chromosome band 17p13.
8657152 DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.
8662907 Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.
9614078 Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.
10362357 cbl-3: a new mammalian cbl family protein.
10733900 Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation.
10964504 NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway.
11870224 Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.
12384576 Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.
12628187 DOCK4, a GTPase activator, is disrupted during tumorigenesis.
12878163 Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
16076871 Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways.
16129412 Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17038317 Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.
17515907 Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.
18024423 Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.
18669648 A quantitative atlas of mitotic phosphorylation.
19004829 DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.
19381274 Unc119 protects from Shigella infection by inhibiting the Abl family kinases.
19807924 Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20534451 Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
A45022 A45022 PIR
SH2 IPR000980 InterPro
SH3_domain IPR001452 InterPro
CRK_SH3_N IPR035457 InterPro
CRK_SH3_C IPR035458 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
SH3_2 PF07653 Pfam
SH2DOMAIN PR00401 PRINTS
SH3DOMAIN PR00452 PRINTS
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
SH2 SM00252 SMART
SH3 SM00326 SMART
SSF50044 SSF50044 SUPFAM
SSF55550 SSF55550 SUPFAM
SH3_CRK_N cd11758 CDD
SH3_CRK_C cd11759 CDD