Protein: Q8TB24

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8TB24 (Uniprot) RIN3_HUMAN RIN3 Ras and Rab interactor 3 human No
Uniprot: Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 462 6.71e-28 7.52e-07
Module ID (MoonGO) GO ID (BP) GO Name
284 GO:0009966 regulation of signal transduction
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
462 GO:0090304 nucleic acid metabolic process
829 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
119 GO:0005829 cytosol
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
462 GO:0005634 nucleus
651 GO:0005829 cytosol
829 GO:0005829 cytosol
829 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006897 endocytosis NAS
GO:0007165 signal transduction IEA
GO:0043547 positive regulation of GTPase activity IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005769 early endosome IDA
GO:0005829 cytosol TAS
GO:0031410 cytoplasmic vesicle IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
11733506 A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.
12508121 The DNA sequence and analysis of human chromosome 14.
12972505 RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18486601 Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles.
21586568 Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31.
No results found.
Domain Name Domain ID Source
RA_dom IPR000159 InterPro
SH2 IPR000980 InterPro
VPS9 IPR003123 InterPro
RIN3_SH2 IPR035869 InterPro
SH2_dom_sf IPR036860 InterPro
VPS9_dom_sf IPR037191 InterPro
VPS9 PF02204 Pfam
SSF109993 SSF109993 SUPFAM
SSF55550 SSF55550 SUPFAM
T50623 T50623 PIR
SH2_RIN3 cd10395 CDD