Protein: Q96LK0

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q96LK0 (Uniprot) CEP19_HUMAN CEP19 Centrosomal protein of 19 kDa human No
Uniprot: Required for ciliation (PubMed:28625565, PubMed:28428259, PubMed:28659385). Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259). Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes (PubMed:28659385). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 52, 694 6.71e-28 7.52e-07
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
52 GO:0090304 nucleic acid metabolic process
173 GO:0034645 cellular macromolecule biosynthetic process
173 GO:0006464 cellular protein modification process
173 GO:0010467 gene expression
173 GO:0035556 intracellular signal transduction
173 GO:0090304 nucleic acid metabolic process
173 GO:0016310 phosphorylation
173 GO:0031325 positive regulation of cellular metabolic process
173 GO:0010604 positive regulation of macromolecule metabolic process
173 GO:0051173 positive regulation of nitrogen compound metabolic process
173 GO:0031326 regulation of cellular biosynthetic process
173 GO:0019219 regulation of nucleobase-containing compound metabolic process
284 GO:0009966 regulation of signal transduction
343 GO:0060255 regulation of macromolecule metabolic process
423 GO:0006464 cellular protein modification process
423 GO:0090304 nucleic acid metabolic process
423 GO:0060255 regulation of macromolecule metabolic process
432 GO:0007165 signal transduction
694 GO:0090304 nucleic acid metabolic process
694 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
52 GO:0005829 cytosol
52 GO:0043232 intracellular non-membrane-bounded organelle
52 GO:0005654 nucleoplasm
101 GO:0005829 cytosol
101 GO:0043232 intracellular non-membrane-bounded organelle
173 GO:0005654 nucleoplasm
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
256 GO:0043232 intracellular non-membrane-bounded organelle
256 GO:0005634 nucleus
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
343 GO:0005634 nucleus
402 GO:0005829 cytosol
423 GO:0005829 cytosol
423 GO:0005634 nucleus
432 GO:0005829 cytosol
432 GO:0005886 plasma membrane
502 GO:0005829 cytosol
502 GO:0031981 nuclear lumen
694 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0034454 microtubule anchoring at centrosome IMP
GO:0060271 cilium assembly IMP
GO:0097712 vesicle targeting, trans-Golgi to periciliary membrane compartment IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000922 spindle pole IDA
GO:0005813 centrosome IDA
GO:0005814 centriole IDA
GO:0005929 cilium IDA
GO:0036064 ciliary basal body IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
TSYL2_HUMAN No
PICK1_HUMAN Yes: Q9NRD5 (MoonDB)
ZBT10_HUMAN No
KAP1_HUMAN No
REL_HUMAN No
GLYR1_HUMAN No
AP3M1_HUMAN No
C102B_HUMAN No
NCK2_HUMAN Yes: O43639 (MoonDB)
P55G_HUMAN Yes: Q92569 (MoonDB)
5NTC_HUMAN No
ABLM1_HUMAN No
AL3A2_HUMAN No
ANR28_HUMAN No
AP3D1_HUMAN No
APC15_HUMAN No
APC1_HUMAN No
C2D1A_HUMAN No
CACO1_HUMAN No
CC74A_HUMAN No
CD019_HUMAN No
CD123_HUMAN No
CDR1_HUMAN No
CE192_HUMAN No
CE350_HUMAN No
CND2_HUMAN No
COPB2_HUMAN No
CR3L2_HUMAN No
CR3L3_HUMAN No
CRK_HUMAN Yes: P46108 (MoonDB)
DICER_HUMAN No
DMBX1_HUMAN No
DVL1_HUMAN No
DVL2_HUMAN No
DVL3_HUMAN Yes: Q92997 (MoonDB)
ECD_HUMAN No
EDC3_HUMAN No
EVI5_HUMAN No
FERM2_HUMAN No
FKBP3_HUMAN No
FOXR1_HUMAN No
FR1OP_HUMAN No
GMEB2_HUMAN No
GNL3_HUMAN No
GPTC1_HUMAN No
GPX1_HUMAN No
HBS1L_HUMAN No
HMGB2_HUMAN No
ILKAP_HUMAN No
INT9_HUMAN No
IPO7_HUMAN No
IPO9_HUMAN No
K1958_HUMAN No
KAD4_HUMAN No
KCD12_HUMAN No
KIFA3_HUMAN No
KXDL1_HUMAN No
LTV1_HUMAN No
MARE1_HUMAN No
METH_HUMAN No
MKL1_HUMAN No
MSH2_HUMAN No
MSH6_HUMAN No
MTA70_HUMAN No
MTMR6_HUMAN No
NMT1_HUMAN No
NUD19_HUMAN No
NVL_HUMAN No
OGA_HUMAN No
P2R3C_HUMAN No
PACE1_HUMAN No
PAPS2_HUMAN No
PARD3_HUMAN No
PDCD4_HUMAN No
PDLI5_HUMAN No
PEX13_HUMAN No
PI42B_HUMAN No
PIBF1_HUMAN No
PIN1_HUMAN No
PKHA1_HUMAN No
PKN2_HUMAN No
PP6R3_HUMAN No
PPP6_HUMAN No
PWP2_HUMAN No
Q6ZT36_HUMAN No
R3HCL_HUMAN No
RABL6_HUMAN No
RBL2A_HUMAN No
RBL2B_HUMAN No
RCOR3_HUMAN No
RENT1_HUMAN No
RINI_HUMAN No
RNZ2_HUMAN No
S23IP_HUMAN No
SCRIB_HUMAN Yes: Q14160 (MoonDB)
SDA1_HUMAN No
SENP3_HUMAN No
SLTM_HUMAN No
SMRCD_HUMAN No
SRGP2_HUMAN No
SRP09_HUMAN No
SRP72_HUMAN No
SRPK1_HUMAN Yes: Q96SB4 (MoonDB)
STK24_HUMAN No
STRN4_HUMAN No
SYNE4_HUMAN No
TBCE_HUMAN No
TCPH_HUMAN No
TERA_HUMAN Yes: P55072 (MoonDB)
TF3C3_HUMAN No
TRAIP_HUMAN No
TRIPC_HUMAN No
TRUA_HUMAN No
TSR1_HUMAN No
TV23B_HUMAN No
UBP5_HUMAN No
UN45A_HUMAN No
VPS52_HUMAN No
WASF2_HUMAN No
WDR83_HUMAN No
YTHD2_HUMAN No
YTHD3_HUMAN No
Z280C_HUMAN No
ZBT14_HUMAN No
ZC3HF_HUMAN No
ZFP1_HUMAN No
PMID Article Title
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
21399614 Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
24268657 Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice.
28428259 RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly.
28625565 The CEP19-RABL2 GTPase complex binds IFT-B to initiate intraflagellar transport at the ciliary base.
28659385 CEP19 cooperates with FOP and CEP350 to drive early steps in the ciliogenesis programme.
OMIM ID Disease Name
615703 Morbid obesity and spermatogenic failure
Domain Name Domain ID Source
CEP19 IPR029412 InterPro
CEP19 PF14933 Pfam
PTHR31539 PTHR31539 PANTHER