Protein: Q96LK0 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q96LK0 (Uniprot)	CEP19_HUMAN	CEP19	Centrosomal protein of 19 kDa	human	No

Protein Function

Uniprot: Required for ciliation (PubMed:28625565, PubMed:28428259, PubMed:28659385). Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at t more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0010646	regulation of cell communication	284	GO:0006139	nucleobase-containing compound metabolic process	52, 694	6.71e-28	7.52e-07

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
52	GO:0090304	nucleic acid metabolic process
173	GO:0034645	cellular macromolecule biosynthetic process
173	GO:0006464	cellular protein modification process
173	GO:0010467	gene expression
173	GO:0035556	intracellular signal transduction
173	GO:0090304	nucleic acid metabolic process
173	GO:0016310	phosphorylation
173	GO:0031325	positive regulation of cellular metabolic process
173	GO:0010604	positive regulation of macromolecule metabolic process
173	GO:0051173	positive regulation of nitrogen compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
52	GO:0005829	cytosol
52	GO:0043232	intracellular non-membrane-bounded organelle
52	GO:0005654	nucleoplasm
101	GO:0005829	cytosol
101	GO:0043232	intracellular non-membrane-bounded organelle
173	GO:0005654	nucleoplasm
190	GO:0005829	cytosol
190	GO:0043232	intracellular non-membrane-bounded organelle
256	GO:0043232	intracellular non-membrane-bounded organelle
256	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0034454	microtubule anchoring at centrosome	IMP
GO:0060271	cilium assembly	IMP
GO:0097712	vesicle targeting, trans-Golgi to periciliary membrane compartment	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000922	spindle pole	IDA
GO:0005813	centrosome	IDA
GO:0005814	centriole	IDA
GO:0005929	cilium	IDA
GO:0036064	ciliary basal body	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
5NTC_HUMAN	No
ABLM1_HUMAN	No
AL3A2_HUMAN	No
ANR28_HUMAN	No
AP3D1_HUMAN	No
AP3M1_HUMAN	No
APC15_HUMAN	No
APC1_HUMAN	No
C102B_HUMAN	No
C2D1A_HUMAN	No

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Publications Associated

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PMID	Article Title
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16641997	The DNA sequence, annotation and analysis of human chromosome 3.
21399614	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
24268657	Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice.
28428259	RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly.
28625565	The CEP19-RABL2 GTPase complex binds IFT-B to initiate intraflagellar transport at the ciliary base.
28659385	CEP19 cooperates with FOP and CEP350 to drive early steps in the ciliogenesis programme.

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OMIM Diseases Associated

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OMIM ID	Disease Name
615703	Morbid obesity and spermatogenic failure

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Protein Domains Associated

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Domain Name	Domain ID	Source
CEP19	IPR029412	InterPro
CEP19	PF14933	Pfam
PTHR31539	PTHR31539	PANTHER

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