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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q9C019
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q9C019 (Uniprot)
TRI15_HUMAN
TRIM15
Tripartite motif-containing protein 15
human
No
Protein Function
No associated function.
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0007165
signal transduction
187
GO:0006725
cellular aromatic compound metabolic process
239
5.44e-126
5.27e-27
GO:0007165
signal transduction
187
GO:0006139
nucleobase-containing compound metabolic process
405
1.10e-111
5.07e-25
GO:0006725
cellular aromatic compound metabolic process
239
GO:0010646
regulation of cell communication
284
4.64e-30
1.07e-07
GO:0010646
regulation of cell communication
284
GO:0006139
nucleobase-containing compound metabolic process
405
6.71e-28
7.52e-07
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
106
GO:0006464
cellular protein modification process
106
GO:0031325
positive regulation of cellular metabolic process
106
GO:0010604
positive regulation of macromolecule metabolic process
106
GO:0051173
positive regulation of nitrogen compound metabolic process
106
GO:0009966
regulation of signal transduction
106
GO:0006355
regulation of transcription, DNA-templated
111
GO:0006955
immune response
111
GO:0035556
intracellular signal transduction
111
GO:0009967
positive regulation of signal transduction
111
GO:0006468
protein phosphorylation
111
GO:0060255
regulation of macromolecule metabolic process
111
GO:0007169
transmembrane receptor protein tyrosine kinase signaling pathway
164
GO:0044267
cellular protein metabolic process
164
GO:0060255
regulation of macromolecule metabolic process
164
GO:0007165
signal transduction
187
GO:0007166
cell surface receptor signaling pathway
187
GO:0006464
cellular protein modification process
187
GO:0070887
cellular response to chemical stimulus
187
GO:0035556
intracellular signal transduction
187
GO:0006928
movement of cell or subcellular component
187
GO:0006796
phosphate-containing compound metabolic process
187
GO:0010647
positive regulation of cell communication
187
GO:0048584
positive regulation of response to stimulus
187
GO:0023056
positive regulation of signaling
187
GO:0060255
regulation of macromolecule metabolic process
187
GO:0009966
regulation of signal transduction
239
GO:0006139
nucleobase-containing compound metabolic process
284
GO:0009966
regulation of signal transduction
405
GO:0090304
nucleic acid metabolic process
405
GO:0060255
regulation of macromolecule metabolic process
405
GO:0019219
regulation of nucleobase-containing compound metabolic process
419
GO:0022607
cellular component assembly
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
106
GO:0005829
cytosol
106
GO:0005654
nucleoplasm
111
GO:0005829
cytosol
111
GO:0005886
plasma membrane
187
GO:0005829
cytosol
187
GO:0005886
plasma membrane
190
GO:0005829
cytosol
190
GO:0043232
intracellular non-membrane-bounded organelle
239
GO:0043232
intracellular non-membrane-bounded organelle
239
GO:0031981
nuclear lumen
284
GO:0005829
cytosol
284
GO:0005886
plasma membrane
405
GO:0005829
cytosol
405
GO:0043232
intracellular non-membrane-bounded organelle
405
GO:0070013
intracellular organelle lumen
405
GO:0005634
nucleus
419
GO:0044430
cytoskeletal part
419
GO:0005829
cytosol
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0007500
mesodermal cell fate determination
TAS
GO:0032481
positive regulation of type I interferon production
IMP
GO:0045087
innate immune response
IMP
GO:0051091
positive regulation of DNA binding transcription factor activity
IMP
GO:0051092
positive regulation of NF-kappaB transcription factor activity
IDA
GO:1900246
positive regulation of RIG-I signaling pathway
IMP
GO:1901253
negative regulation of intracellular transport of viral material
IMP
GO:1902187
negative regulation of viral release from host cell
IMP
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005622
intracellular
IEA
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
KEAP1_HUMAN
No
NCK2_HUMAN
Yes:
O43639 (MoonDB)
F161A_HUMAN
No
F161B_HUMAN
No
SRC8_HUMAN
Yes:
Q14247 (MoonDB)
AKT1_HUMAN
No
VIME_HUMAN
Yes:
P08670 (MoonDB)
RABX5_HUMAN
No
T2EA_HUMAN
No
FAK1_HUMAN
No
SHC1_HUMAN
No
SRC_HUMAN
Yes:
P12931 (MoonDB)
CRK_HUMAN
Yes:
P46108 (MoonDB)
VASP_HUMAN
Yes:
P50552 (MoonDB)
KSYK_HUMAN
Yes:
P43405 (MoonDB)
GAB1_HUMAN
Yes:
Q13480 (MoonDB)
TRIM8_HUMAN
Yes:
Q9BZR9 (MoonDB)
ACTB_HUMAN
No
UBE2U_HUMAN
Yes:
Q5VVX9 (MoonDB)
MOES_HUMAN
No
MED7_HUMAN
No
COR1B_HUMAN
No
CDK6_HUMAN
Yes:
Q00534 (MoonDB)
ROCK1_HUMAN
No
SNW1_HUMAN
No
IRF5_HUMAN
No
VINC_HUMAN
No
FBLI1_HUMAN
No
URP2_HUMAN
No
CCD94_HUMAN
No
COF1_HUMAN
No
NEXN_HUMAN
No
PROF1_HUMAN
No
MYBB_HUMAN
No
ACD_HUMAN
Yes:
Q96AP0 (MoonDB)
TINF2_HUMAN
Yes:
Q9BSI4 (MoonDB)
EHMT1_HUMAN
No
APRIO_HUMAN
No
F151B_HUMAN
No
FERM2_HUMAN
No
TAF9B_HUMAN
No
Publications Associated
PMID
Article Title
8304341
Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection.
11331580
The tripartite motif family identifies cell compartments.
14574404
The DNA sequence and analysis of human chromosome 6.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
Znf_B-box
IPR000315
InterPro
Znf_RING
IPR001841
InterPro
B30.2/SPRY
IPR001870
InterPro
SPRY_dom
IPR003877
InterPro
Butyrophylin_SPRY
IPR003879
InterPro
PRY
IPR006574
InterPro
Znf_RING/FYVE/PHD
IPR013083
InterPro
ConA-like_dom_sf
IPR013320
InterPro
Znf_RING_CS
IPR017907
InterPro
Znf_C3HC4_RING-type
IPR018957
InterPro
zf-C3HC4
PF00097
Pfam
SPRY
PF00622
Pfam
zf-B_box
PF00643
Pfam
PRY
PF13765
Pfam
BUTYPHLNCDUF
PR01407
PRINTS
ZF_RING_1
PS00518
PROSITE
ZF_RING_2
PS50089
PROSITE
ZF_BBOX
PS50119
PROSITE
B302_SPRY
PS50188
PROSITE
RING
SM00184
SMART
BBOX
SM00336
SMART
SPRY
SM00449
SMART
PRY
SM00589
SMART
SSF49899
SSF49899
SUPFAM
BBOX
cd00021
CDD