Protein: Q00534

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q00534 (Uniprot) CDK6_HUMAN CDK6 Cyclin-dependent kinase 6 human No
Uniprot: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 106, 330 GO:0016070 RNA metabolic process 689 5.81e-04 8.44e-05
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
6 GO:0034645 cellular macromolecule biosynthetic process
6 GO:0010467 gene expression
6 GO:0090304 nucleic acid metabolic process
6 GO:0060255 regulation of macromolecule metabolic process
51 GO:0060255 regulation of macromolecule metabolic process
64 GO:0016070 RNA metabolic process
64 GO:0010467 gene expression
64 GO:0060255 regulation of macromolecule metabolic process
106 GO:0006464 cellular protein modification process
106 GO:0031325 positive regulation of cellular metabolic process
106 GO:0010604 positive regulation of macromolecule metabolic process
106 GO:0051173 positive regulation of nitrogen compound metabolic process
106 GO:0009966 regulation of signal transduction
106 GO:0006355 regulation of transcription, DNA-templated
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
689 GO:0006396 RNA processing
689 GO:0051252 regulation of RNA metabolic process
689 GO:0010468 regulation of gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
6 GO:0043232 intracellular non-membrane-bounded organelle
6 GO:0005654 nucleoplasm
51 GO:0005634 nucleus
64 GO:0005634 nucleus
106 GO:0005829 cytosol
106 GO:0005654 nucleoplasm
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
689 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000082 G1/S transition of mitotic cell cycle TAS
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA
GO:0001954 positive regulation of cell-matrix adhesion IDA
GO:0003323 type B pancreatic cell development IDA
GO:0006468 protein phosphorylation IDA
GO:0007050 cell cycle arrest TAS
GO:0007165 signal transduction IBA
GO:0007219 Notch signaling pathway IEA
GO:0008285 negative regulation of cell proliferation TAS
GO:0009615 response to virus IEP
GO:0010389 regulation of G2/M transition of mitotic cell cycle IBA
GO:0010468 regulation of gene expression IMP
GO:0010628 positive regulation of gene expression IEA
GO:0014002 astrocyte development ISS
GO:0021542 dentate gyrus development ISS
GO:0021670 lateral ventricle development ISS
GO:0033077 T cell differentiation in thymus IEA
GO:0042063 gliogenesis IMP
GO:0043697 cell dedifferentiation IMP
GO:0045596 negative regulation of cell differentiation TAS
GO:0045638 negative regulation of myeloid cell differentiation IDA
GO:0045646 regulation of erythrocyte differentiation IMP
GO:0045656 negative regulation of monocyte differentiation IDA
GO:0045668 negative regulation of osteoblast differentiation IDA
GO:0045786 negative regulation of cell cycle IDA
GO:0048146 positive regulation of fibroblast proliferation IMP
GO:0048699 generation of neurons ISS
GO:0050680 negative regulation of epithelial cell proliferation IMP
GO:0051301 cell division IEA
GO:0060218 hematopoietic stem cell differentiation IEA
GO:1902036 regulation of hematopoietic stem cell differentiation IEA
GO:1904628 cellular response to phorbol 13-acetate 12-myristate IDA
GO:2000145 regulation of cell motility ISS
GO:2000773 negative regulation of cellular senescence IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA
GO:0001726 ruffle IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005813 centrosome IDA
GO:0005829 cytosol TAS
GO:0097132 cyclin D2-CDK6 complex IEA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
DAB1_HUMAN No
PSA3_HUMAN Yes: P25788 (MoonDB)
PROP1_HUMAN No
ATX1_HUMAN Yes: P54253 (MoonDB)
CDN2D_HUMAN No
HS90B_HUMAN Yes: P08238 (MoonDB)
POGZ_HUMAN No
CBY1_HUMAN No
HSF1_HUMAN Yes: Q00613 (MoonDB)
DDIT3_HUMAN No
RUNX1_HUMAN No
CDC37_HUMAN Yes: Q16543 (MoonDB)
CDN2B_HUMAN No
SRS11_HUMAN No
SNIP1_HUMAN Yes: Q8TAD8 (MoonDB)
MCM2_HUMAN No
UHRF2_HUMAN No
CDN2C_HUMAN No
SOX5_HUMAN No
RBL2_HUMAN No
TRA2A_HUMAN No
CDN1A_HUMAN Yes: P38936 (MoonDB)
CDN2A_HUMAN No
MCM10_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
SOX10_HUMAN No
MYC_HUMAN No
CTNB1_HUMAN No
SRSF1_HUMAN No
ABI1_HUMAN No
SRSF7_HUMAN No
OTP_HUMAN No
RB_HUMAN No
EZH2_HUMAN No
RBM23_HUMAN No
TFDP1_HUMAN No
ELOA2_HUMAN No
CCNH_HUMAN No
FOXO3_HUMAN No
TPX2_HUMAN No
CDN1B_HUMAN Yes: P46527 (MoonDB)
RBL1_HUMAN No
PML_HUMAN No
CASC3_HUMAN No
4ET_HUMAN No
ABEC1_HUMAN No
AF9_HUMAN No
ANR12_HUMAN No
ARF_HUMAN No
ATF6B_HUMAN No
BC11A_HUMAN No
CCND1_HUMAN No
CCND3_HUMAN No
CCNI_HUMAN No
CDC6_HUMAN No
CDK2_HUMAN No
CLASR_HUMAN No
COE4_HUMAN No
DEDD2_HUMAN No
ELK1_HUMAN No
FOXM1_HUMAN No
ISL1_HUMAN No
KLF10_HUMAN No
LPIN1_HUMAN No
MEF2D_HUMAN No
MS3L1_HUMAN No
MZF1_HUMAN No
N4BP1_HUMAN No
NFAC3_HUMAN No
NIPBL_HUMAN No
NUMA1_HUMAN No
PPHLN_HUMAN No
PRAX_HUMAN No
PRGC1_HUMAN No
SENP3_HUMAN No
SIR1_HUMAN No
SLBP_HUMAN No
SRBS1_HUMAN No
SRS12_HUMAN No
SRSF2_HUMAN No
SSBP2_HUMAN No
SYNP2_HUMAN No
TRA2B_HUMAN No
TRAK1_HUMAN No
TRI15_HUMAN Yes: Q9C019 (MoonDB)
VGLL4_HUMAN No
ZEB1_HUMAN No
ZMYM3_HUMAN No
ZN101_HUMAN No
ZN174_HUMAN No
ZN335_HUMAN No
ZN823_HUMAN No
ZO2_HUMAN No
ZSCA1_HUMAN No
PMID Article Title
1639063 A family of human cdc2-related protein kinases.
8114739 Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
9482106 Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.
9751050 Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
11124804 Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.
11828325 Structural basis for CDK6 activation by a virus-encoded cyclin.
12690205 Human chromosome 7: DNA sequence and biology.
12833137 CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells.
12853948 The DNA sequence of human chromosome 7.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14985467 Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.
15254224 Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15689157 Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
15809340 Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro.
16096642 Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.
16294322 Beyond the cell cycle: a new role for Cdk6 in differentiation.
16548883 Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
16789739 Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.
17344846 Patterns of somatic mutation in human cancer genomes.
17420273 CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.
17431401 Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.
19139263 A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.
19238148 Cell cycle, CDKs and cancer: a changing paradigm.
19369195 Large-scale proteomics analysis of the human kinome.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20333249 Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.
20668294 Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6.
21038853 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.
21269460 Initial characterization of the human central proteome.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23918663 CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly.
OMIM ID Disease Name
616080 Microcephaly 12, primary, autosomal recessive
Domain Name Domain ID Source
Prot_kinase_dom IPR000719 InterPro
Ser/Thr_kinase_AS IPR008271 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
CDK6 IPR028788 InterPro
Pkinase PF00069 Pfam
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_ST PS00108 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
S23387 S23387 PIR
S_TKc SM00220 SMART
SSF56112 SSF56112 SUPFAM
STKc_CDK6 cd07862 CDD