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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q00534
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q00534 (Uniprot)
CDK6_HUMAN
CDK6
Cyclin-dependent kinase 6
human
No
Protein Function
Uniprot:
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and main
tenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
more..
MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0036211
protein modification process
106
,
330
GO:0016070
RNA metabolic process
689
5.81e-04
8.44e-05
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 28 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
6
GO:0034645
cellular macromolecule biosynthetic process
6
GO:0010467
gene expression
6
GO:0090304
nucleic acid metabolic process
6
GO:0060255
regulation of macromolecule metabolic process
51
GO:0060255
regulation of macromolecule metabolic process
64
GO:0016070
RNA metabolic process
64
GO:0010467
gene expression
64
GO:0060255
regulation of macromolecule metabolic process
106
GO:0006464
cellular protein modification process
106
GO:0031325
positive regulation of cellular metabolic process
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Cellular Components
Showing 1 to 9 of 9 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
6
GO:0043232
intracellular non-membrane-bounded organelle
6
GO:0005654
nucleoplasm
51
GO:0005634
nucleus
64
GO:0005634
nucleus
106
GO:0005829
cytosol
106
GO:0005654
nucleoplasm
330
GO:0005829
cytosol
330
GO:0005654
nucleoplasm
689
GO:0005654
nucleoplasm
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 34 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000082
G1/S transition of mitotic cell cycle
TAS
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
IEA
GO:0001954
positive regulation of cell-matrix adhesion
IDA
GO:0003323
type B pancreatic cell development
IDA
GO:0006468
protein phosphorylation
IDA
GO:0007050
cell cycle arrest
TAS
GO:0007165
signal transduction
IBA
GO:0007219
Notch signaling pathway
IEA
GO:0008285
negative regulation of cell proliferation
TAS
GO:0009615
response to virus
IEP
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Cellular Components
Showing 1 to 8 of 8 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000307
cyclin-dependent protein kinase holoenzyme complex
IDA
GO:0001726
ruffle
IDA
GO:0005634
nucleus
IDA
GO:0005654
nucleoplasm
TAS
GO:0005737
cytoplasm
IDA
GO:0005813
centrosome
IDA
GO:0005829
cytosol
TAS
GO:0097132
cyclin D2-CDK6 complex
IEA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 94 entries
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Interactor
Also a MoonDB EMF protein
4ET_HUMAN
No
ABEC1_HUMAN
No
ABI1_HUMAN
No
AF9_HUMAN
No
ANDR_HUMAN
Yes:
P10275 (MoonDB)
ANR12_HUMAN
No
ARF_HUMAN
No
ATF6B_HUMAN
No
ATX1_HUMAN
Yes:
P54253 (MoonDB)
BC11A_HUMAN
No
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Publications Associated
Showing 1 to 10 of 34 entries
Search:
PMID
Article Title
1639063
A family of human cdc2-related protein kinases.
8114739
Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
9482106
Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.
9751050
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
11124804
Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.
11828325
Structural basis for CDK6 activation by a virus-encoded cyclin.
12690205
Human chromosome 7: DNA sequence and biology.
12833137
CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells.
12853948
The DNA sequence of human chromosome 7.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
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OMIM Diseases Associated
Showing 1 to 1 of 1 entries
Search:
OMIM ID
Disease Name
616080
Microcephaly 12, primary, autosomal recessive
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Protein Domains Associated
Showing 1 to 10 of 13 entries
Search:
Domain Name
Domain ID
Source
CDK6
IPR028788
InterPro
Kinase-like_dom_sf
IPR011009
InterPro
Pkinase
PF00069
Pfam
Prot_kinase_dom
IPR000719
InterPro
PROTEIN_KINASE_ATP
PS00107
PROSITE
Protein_kinase_ATP_BS
IPR017441
InterPro
PROTEIN_KINASE_DOM
PS50011
PROSITE
PROTEIN_KINASE_ST
PS00108
PROSITE
S23387
S23387
PIR
S_TKc
SM00220
SMART
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