Protein: P08238

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P08238 (Uniprot) HS90B_HUMAN HSP90AB1 Heat shock protein HSP 90-beta human No
Uniprot: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone that is involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 2, 181, 292, 304, 316, 474, 514, 545 GO:0016070 RNA metabolic process 689 5.15e-08 2.82e-13
GO:0036211 protein modification process 28, 32, 106, 138, 155, 159, 221, 247, 290, 301, 381, 482, 483, 560, 579, 599, 668 GO:0016070 RNA metabolic process 689 5.81e-04 8.44e-05
GO:0007166 cell surface receptor signaling pathway 108 GO:0006725 cellular aromatic compound metabolic process 81, 395, 484, 683 3.09e-47 2.24e-87
GO:0007166 cell surface receptor signaling pathway 108 GO:0009059 macromolecule biosynthetic process 157, 192, 211, 833 2.49e-18 9.18e-29
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 356, 612 6.88e-41 1.21e-84
GO:0007166 cell surface receptor signaling pathway 108 GO:0016070 RNA metabolic process 689 1.03e-23 1.51e-118
GO:0002376 immune system process 111 GO:0016070 RNA metabolic process 689 5.68e-23 7.16e-26
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 157, 192, 211, 833 6.37e-04 1.88e-40
GO:0007165 signal transduction 141, 169, 282, 308, 512 GO:0006725 cellular aromatic compound metabolic process 81, 395, 484, 683 5.44e-126 5.27e-27
GO:0007165 signal transduction 141, 169, 282, 308, 512 GO:0006139 nucleobase-containing compound metabolic process 356, 612 1.10e-111 5.07e-25
GO:0007165 signal transduction 141, 169, 282, 308, 512 GO:0016070 RNA metabolic process 689 3.11e-78 2.75e-26
GO:0009059 macromolecule biosynthetic process 157, 192, 211 GO:0006928 movement of cell or subcellular component 496 1.49e-13 8.46e-109
GO:0006464 cellular protein modification process 195 GO:0016070 RNA metabolic process 689 5.81e-04 8.44e-05
GO:0006139 nucleobase-containing compound metabolic process 356 GO:0006928 movement of cell or subcellular component 496 1.95e-31 6.36e-195
GO:0006725 cellular aromatic compound metabolic process 395, 484 GO:0006928 movement of cell or subcellular component 496 1.24e-32 2.63e-196
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
2 GO:0044267 cellular protein metabolic process
2 GO:0010467 gene expression
2 GO:0006139 nucleobase-containing compound metabolic process
2 GO:0060255 regulation of macromolecule metabolic process
2 GO:0007165 signal transduction
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
28 GO:0006464 cellular protein modification process
28 GO:0031324 negative regulation of cellular metabolic process
28 GO:0010605 negative regulation of macromolecule metabolic process
28 GO:0051172 negative regulation of nitrogen compound metabolic process
28 GO:0031325 positive regulation of cellular metabolic process
28 GO:0010604 positive regulation of macromolecule metabolic process
28 GO:0051173 positive regulation of nitrogen compound metabolic process
28 GO:0048584 positive regulation of response to stimulus
28 GO:0009966 regulation of signal transduction
28 GO:0006355 regulation of transcription, DNA-templated
32 GO:0006464 cellular protein modification process
32 GO:0006955 immune response
32 GO:0002682 regulation of immune system process
32 GO:0007165 signal transduction
45 GO:0071495 cellular response to endogenous stimulus
45 GO:0071310 cellular response to organic substance
45 GO:0032270 positive regulation of cellular protein metabolic process
45 GO:0006468 protein phosphorylation
45 GO:0042325 regulation of phosphorylation
45 GO:0009966 regulation of signal transduction
81 GO:0006139 nucleobase-containing compound metabolic process
106 GO:0006464 cellular protein modification process
106 GO:0031325 positive regulation of cellular metabolic process
106 GO:0010604 positive regulation of macromolecule metabolic process
106 GO:0051173 positive regulation of nitrogen compound metabolic process
106 GO:0009966 regulation of signal transduction
106 GO:0006355 regulation of transcription, DNA-templated
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
138 GO:0006464 cellular protein modification process
138 GO:0007165 signal transduction
141 GO:0035556 intracellular signal transduction
141 GO:0006468 protein phosphorylation
141 GO:0060255 regulation of macromolecule metabolic process
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
157 GO:0034645 cellular macromolecule biosynthetic process
157 GO:0044267 cellular protein metabolic process
157 GO:0090304 nucleic acid metabolic process
159 GO:0006464 cellular protein modification process
159 GO:0006355 regulation of transcription, DNA-templated
159 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
192 GO:0034645 cellular macromolecule biosynthetic process
192 GO:0006464 cellular protein modification process
192 GO:0010467 gene expression
192 GO:0090304 nucleic acid metabolic process
192 GO:0009893 positive regulation of metabolic process
192 GO:0060255 regulation of macromolecule metabolic process
192 GO:0007165 signal transduction
195 GO:0006468 protein phosphorylation
195 GO:0010468 regulation of gene expression
195 GO:0051246 regulation of protein metabolic process
195 GO:0007165 signal transduction
205 GO:0071310 cellular response to organic substance
205 GO:0007167 enzyme linked receptor protein signaling pathway
205 GO:0090304 nucleic acid metabolic process
205 GO:0034654 nucleobase-containing compound biosynthetic process
205 GO:0043085 positive regulation of catalytic activity
205 GO:0031325 positive regulation of cellular metabolic process
205 GO:0010604 positive regulation of macromolecule metabolic process
205 GO:0051173 positive regulation of nitrogen compound metabolic process
205 GO:0009967 positive regulation of signal transduction
205 GO:0006468 protein phosphorylation
205 GO:2000112 regulation of cellular macromolecule biosynthetic process
205 GO:0032268 regulation of cellular protein metabolic process
205 GO:0010468 regulation of gene expression
205 GO:1902531 regulation of intracellular signal transduction
205 GO:0019219 regulation of nucleobase-containing compound metabolic process
205 GO:0042325 regulation of phosphorylation
205 GO:0051049 regulation of transport
211 GO:0034645 cellular macromolecule biosynthetic process
211 GO:0044271 cellular nitrogen compound biosynthetic process
211 GO:0090304 nucleic acid metabolic process
211 GO:0060255 regulation of macromolecule metabolic process
221 GO:0006464 cellular protein modification process
221 GO:0071310 cellular response to organic substance
221 GO:0031325 positive regulation of cellular metabolic process
221 GO:0010604 positive regulation of macromolecule metabolic process
221 GO:0051173 positive regulation of nitrogen compound metabolic process
221 GO:0006357 regulation of transcription from RNA polymerase II promoter
221 GO:0007165 signal transduction
247 GO:0006464 cellular protein modification process
247 GO:0060255 regulation of macromolecule metabolic process
247 GO:0007165 signal transduction
282 GO:0035556 intracellular signal transduction
282 GO:0043085 positive regulation of catalytic activity
282 GO:0031325 positive regulation of cellular metabolic process
282 GO:0051173 positive regulation of nitrogen compound metabolic process
282 GO:0060255 regulation of macromolecule metabolic process
282 GO:0019220 regulation of phosphate metabolic process
290 GO:0006464 cellular protein modification process
290 GO:0031325 positive regulation of cellular metabolic process
290 GO:0009889 regulation of biosynthetic process
290 GO:0060255 regulation of macromolecule metabolic process
290 GO:0007165 signal transduction
292 GO:0044267 cellular protein metabolic process
292 GO:0010467 gene expression
301 GO:0006464 cellular protein modification process
301 GO:0060255 regulation of macromolecule metabolic process
304 GO:0044267 cellular protein metabolic process
304 GO:0007165 signal transduction
308 GO:0007166 cell surface receptor signaling pathway
308 GO:0071310 cellular response to organic substance
308 GO:0035556 intracellular signal transduction
308 GO:0043085 positive regulation of catalytic activity
308 GO:0031328 positive regulation of cellular biosynthetic process
308 GO:0010604 positive regulation of macromolecule metabolic process
308 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
308 GO:0009967 positive regulation of signal transduction
308 GO:0006468 protein phosphorylation
308 GO:0031399 regulation of protein modification process
308 GO:0006355 regulation of transcription, DNA-templated
316 GO:0044267 cellular protein metabolic process
316 GO:0060255 regulation of macromolecule metabolic process
323 GO:0016070 RNA metabolic process
323 GO:0034654 nucleobase-containing compound biosynthetic process
323 GO:0009893 positive regulation of metabolic process
323 GO:0006468 protein phosphorylation
323 GO:2000112 regulation of cellular macromolecule biosynthetic process
323 GO:0010468 regulation of gene expression
323 GO:0019219 regulation of nucleobase-containing compound metabolic process
323 GO:0007165 signal transduction
331 GO:0016070 RNA metabolic process
331 GO:0006464 cellular protein modification process
331 GO:0010467 gene expression
331 GO:0060255 regulation of macromolecule metabolic process
331 GO:0019219 regulation of nucleobase-containing compound metabolic process
337 GO:0022607 cellular component assembly
337 GO:0035556 intracellular signal transduction
337 GO:0006468 protein phosphorylation
337 GO:0060255 regulation of macromolecule metabolic process
356 GO:0034654 nucleobase-containing compound biosynthetic process
356 GO:0006468 protein phosphorylation
356 GO:0051252 regulation of RNA metabolic process
356 GO:2000112 regulation of cellular macromolecule biosynthetic process
356 GO:0010468 regulation of gene expression
356 GO:0007165 signal transduction
381 GO:0006464 cellular protein modification process
381 GO:0010467 gene expression
381 GO:0016310 phosphorylation
381 GO:0010604 positive regulation of macromolecule metabolic process
381 GO:0050790 regulation of catalytic activity
381 GO:0032268 regulation of cellular protein metabolic process
381 GO:0007165 signal transduction
395 GO:0006139 nucleobase-containing compound metabolic process
395 GO:0019538 protein metabolic process
435 GO:0031325 positive regulation of cellular metabolic process
435 GO:0010604 positive regulation of macromolecule metabolic process
435 GO:0051173 positive regulation of nitrogen compound metabolic process
435 GO:0019538 protein metabolic process
435 GO:0006357 regulation of transcription from RNA polymerase II promoter
435 GO:0007165 signal transduction
474 GO:0044267 cellular protein metabolic process
474 GO:0090304 nucleic acid metabolic process
474 GO:0060255 regulation of macromolecule metabolic process
482 GO:0006464 cellular protein modification process
482 GO:0007167 enzyme linked receptor protein signaling pathway
482 GO:0006796 phosphate-containing compound metabolic process
482 GO:0032268 regulation of cellular protein metabolic process
482 GO:0009966 regulation of signal transduction
483 GO:0006464 cellular protein modification process
483 GO:0010467 gene expression
483 GO:0009059 macromolecule biosynthetic process
483 GO:0090304 nucleic acid metabolic process
483 GO:0060255 regulation of macromolecule metabolic process
483 GO:0007165 signal transduction
484 GO:0006139 nucleobase-containing compound metabolic process
484 GO:1901362 organic cyclic compound biosynthetic process
484 GO:0019538 protein metabolic process
484 GO:0060255 regulation of macromolecule metabolic process
484 GO:0007165 signal transduction
496 GO:0048870 cell motility
496 GO:0071310 cellular response to organic substance
496 GO:0090304 nucleic acid metabolic process
496 GO:0034654 nucleobase-containing compound biosynthetic process
496 GO:0043085 positive regulation of catalytic activity
496 GO:0031325 positive regulation of cellular metabolic process
496 GO:1902533 positive regulation of intracellular signal transduction
496 GO:0010604 positive regulation of macromolecule metabolic process
496 GO:0051173 positive regulation of nitrogen compound metabolic process
496 GO:0051128 regulation of cellular component organization
496 GO:2000112 regulation of cellular macromolecule biosynthetic process
496 GO:0010468 regulation of gene expression
496 GO:0043549 regulation of kinase activity
496 GO:0019219 regulation of nucleobase-containing compound metabolic process
496 GO:0001932 regulation of protein phosphorylation
496 GO:0009719 response to endogenous stimulus
496 GO:1901700 response to oxygen-containing compound
496 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
512 GO:0035556 intracellular signal transduction
512 GO:0006468 protein phosphorylation
512 GO:0060255 regulation of macromolecule metabolic process
514 GO:0044267 cellular protein metabolic process
514 GO:0071310 cellular response to organic substance
514 GO:0033554 cellular response to stress
514 GO:0035556 intracellular signal transduction
514 GO:0031328 positive regulation of cellular biosynthetic process
514 GO:0010557 positive regulation of macromolecule biosynthetic process
514 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
514 GO:0042981 regulation of apoptotic process
514 GO:0010646 regulation of cell communication
514 GO:0023051 regulation of signaling
514 GO:0006357 regulation of transcription from RNA polymerase II promoter
545 GO:0044267 cellular protein metabolic process
545 GO:0006139 nucleobase-containing compound metabolic process
549 GO:0008219 cell death
549 GO:0070887 cellular response to chemical stimulus
549 GO:0033554 cellular response to stress
549 GO:0035556 intracellular signal transduction
549 GO:0031325 positive regulation of cellular metabolic process
549 GO:0010604 positive regulation of macromolecule metabolic process
549 GO:0051173 positive regulation of nitrogen compound metabolic process
549 GO:0048584 positive regulation of response to stimulus
549 GO:0006468 protein phosphorylation
549 GO:0051252 regulation of RNA metabolic process
549 GO:2000112 regulation of cellular macromolecule biosynthetic process
549 GO:0032268 regulation of cellular protein metabolic process
549 GO:0010468 regulation of gene expression
549 GO:0009966 regulation of signal transduction
549 GO:0006351 transcription, DNA-templated
560 GO:0006464 cellular protein modification process
560 GO:0060255 regulation of macromolecule metabolic process
560 GO:0007165 signal transduction
579 GO:0006464 cellular protein modification process
579 GO:0060255 regulation of macromolecule metabolic process
579 GO:0007165 signal transduction
599 GO:0006464 cellular protein modification process
599 GO:0016310 phosphorylation
612 GO:0090304 nucleic acid metabolic process
612 GO:0031325 positive regulation of cellular metabolic process
612 GO:0010604 positive regulation of macromolecule metabolic process
612 GO:0051173 positive regulation of nitrogen compound metabolic process
612 GO:0006468 protein phosphorylation
612 GO:0032268 regulation of cellular protein metabolic process
612 GO:0010468 regulation of gene expression
612 GO:0010556 regulation of macromolecule biosynthetic process
612 GO:0019219 regulation of nucleobase-containing compound metabolic process
612 GO:0042325 regulation of phosphorylation
612 GO:0009966 regulation of signal transduction
661 GO:0016070 RNA metabolic process
661 GO:0010467 gene expression
668 GO:0006464 cellular protein modification process
668 GO:0006796 phosphate-containing compound metabolic process
683 GO:0006139 nucleobase-containing compound metabolic process
683 GO:0060255 regulation of macromolecule metabolic process
685 GO:0060255 regulation of macromolecule metabolic process
685 GO:0007165 signal transduction
689 GO:0006396 RNA processing
689 GO:0051252 regulation of RNA metabolic process
689 GO:0010468 regulation of gene expression
692 GO:0016070 RNA metabolic process
692 GO:0044271 cellular nitrogen compound biosynthetic process
692 GO:0010467 gene expression
692 GO:0019538 protein metabolic process
692 GO:2000112 regulation of cellular macromolecule biosynthetic process
695 GO:0006464 cellular protein modification process
695 GO:0035556 intracellular signal transduction
695 GO:0016310 phosphorylation
695 GO:0060255 regulation of macromolecule metabolic process
724 GO:0016070 RNA metabolic process
724 GO:0035556 intracellular signal transduction
724 GO:0009892 negative regulation of metabolic process
724 GO:0034654 nucleobase-containing compound biosynthetic process
724 GO:0006468 protein phosphorylation
724 GO:2000112 regulation of cellular macromolecule biosynthetic process
724 GO:0032268 regulation of cellular protein metabolic process
724 GO:0010468 regulation of gene expression
724 GO:0019219 regulation of nucleobase-containing compound metabolic process
761 GO:0031324 negative regulation of cellular metabolic process
761 GO:0010605 negative regulation of macromolecule metabolic process
761 GO:0051172 negative regulation of nitrogen compound metabolic process
761 GO:0090304 nucleic acid metabolic process
761 GO:0034654 nucleobase-containing compound biosynthetic process
761 GO:2000112 regulation of cellular macromolecule biosynthetic process
761 GO:0019219 regulation of nucleobase-containing compound metabolic process
816 GO:0016070 RNA metabolic process
816 GO:0010467 gene expression
816 GO:0034654 nucleobase-containing compound biosynthetic process
816 GO:0010646 regulation of cell communication
816 GO:2000112 regulation of cellular macromolecule biosynthetic process
816 GO:0019219 regulation of nucleobase-containing compound metabolic process
816 GO:0023051 regulation of signaling
816 GO:0007165 signal transduction
821 GO:0006259 DNA metabolic process
821 GO:0007166 cell surface receptor signaling pathway
821 GO:0034613 cellular protein localization
821 GO:0071495 cellular response to endogenous stimulus
821 GO:0071310 cellular response to organic substance
821 GO:0031324 negative regulation of cellular metabolic process
821 GO:0010605 negative regulation of macromolecule metabolic process
821 GO:0051172 negative regulation of nitrogen compound metabolic process
821 GO:0031328 positive regulation of cellular biosynthetic process
821 GO:0010557 positive regulation of macromolecule biosynthetic process
821 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
821 GO:0048584 positive regulation of response to stimulus
821 GO:0006468 protein phosphorylation
821 GO:0031399 regulation of protein modification process
821 GO:0006355 regulation of transcription, DNA-templated
821 GO:1901700 response to oxygen-containing compound
833 GO:0034645 cellular macromolecule biosynthetic process
833 GO:0006464 cellular protein modification process
833 GO:0006796 phosphate-containing compound metabolic process
833 GO:0060255 regulation of macromolecule metabolic process
849 GO:0022607 cellular component assembly
849 GO:0006464 cellular protein modification process
849 GO:0006796 phosphate-containing compound metabolic process
849 GO:0010646 regulation of cell communication
849 GO:0023051 regulation of signaling
849 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
2 GO:0005829 cytosol
2 GO:0005634 nucleus
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
28 GO:0005829 cytosol
28 GO:0043232 intracellular non-membrane-bounded organelle
28 GO:0005654 nucleoplasm
32 GO:0005886 plasma membrane
32 GO:0031982 vesicle
45 GO:0005829 cytosol
45 GO:0031981 nuclear lumen
45 GO:0005886 plasma membrane
81 GO:0005829 cytosol
81 GO:0031981 nuclear lumen
106 GO:0005829 cytosol
106 GO:0005654 nucleoplasm
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
125 GO:0005829 cytosol
125 GO:0005634 nucleus
138 GO:0005634 nucleus
141 GO:0005634 nucleus
155 GO:0005634 nucleus
157 GO:0005654 nucleoplasm
159 GO:0005829 cytosol
159 GO:0005654 nucleoplasm
162 GO:0005634 nucleus
169 GO:0005654 nucleoplasm
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
192 GO:0005829 cytosol
192 GO:0005654 nucleoplasm
195 GO:0005829 cytosol
195 GO:0005634 nucleus
205 GO:0005829 cytosol
205 GO:0005634 nucleus
205 GO:0005886 plasma membrane
211 GO:0005829 cytosol
211 GO:0031981 nuclear lumen
216 GO:0005829 cytosol
221 GO:0005829 cytosol
221 GO:0043232 intracellular non-membrane-bounded organelle
221 GO:0005654 nucleoplasm
226 GO:0005634 nucleus
247 GO:0005634 nucleus
282 GO:0005829 cytosol
282 GO:0005886 plasma membrane
290 GO:0005829 cytosol
290 GO:0031982 vesicle
292 GO:0043232 intracellular non-membrane-bounded organelle
292 GO:0031981 nuclear lumen
301 GO:0005829 cytosol
301 GO:0005634 nucleus
308 GO:0005829 cytosol
308 GO:0070013 intracellular organelle lumen
308 GO:0044428 nuclear part
308 GO:0005886 plasma membrane
316 GO:0005634 nucleus
323 GO:0005829 cytosol
323 GO:0043232 intracellular non-membrane-bounded organelle
323 GO:0070013 intracellular organelle lumen
323 GO:0044428 nuclear part
331 GO:0005654 nucleoplasm
337 GO:0005829 cytosol
337 GO:0043232 intracellular non-membrane-bounded organelle
337 GO:0005634 nucleus
356 GO:0005634 nucleus
381 GO:0005829 cytosol
381 GO:0005634 nucleus
388 GO:0016021 integral component of membrane
395 GO:0005634 nucleus
411 GO:0005634 nucleus
435 GO:0005654 nucleoplasm
482 GO:0005576 extracellular region
483 GO:0005829 cytosol
483 GO:0031981 nuclear lumen
484 GO:0070013 intracellular organelle lumen
484 GO:0005634 nucleus
496 GO:0005829 cytosol
496 GO:0005634 nucleus
496 GO:0005886 plasma membrane
512 GO:0005829 cytosol
514 GO:0005654 nucleoplasm
545 GO:0005829 cytosol
545 GO:0005634 nucleus
545 GO:0031982 vesicle
549 GO:0005829 cytosol
549 GO:0005634 nucleus
560 GO:0005829 cytosol
612 GO:0005634 nucleus
661 GO:0005654 nucleoplasm
671 GO:0005829 cytosol
671 GO:0070013 intracellular organelle lumen
671 GO:0005634 nucleus
683 GO:0005829 cytosol
683 GO:0070013 intracellular organelle lumen
683 GO:0005634 nucleus
685 GO:0005829 cytosol
689 GO:0005654 nucleoplasm
692 GO:0031981 nuclear lumen
695 GO:0005829 cytosol
695 GO:0005634 nucleus
724 GO:0005829 cytosol
724 GO:0070013 intracellular organelle lumen
724 GO:0005634 nucleus
761 GO:0005654 nucleoplasm
816 GO:0005654 nucleoplasm
821 GO:0005829 cytosol
821 GO:0005654 nucleoplasm
821 GO:0005886 plasma membrane
833 GO:0005829 cytosol
849 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001890 placenta development IEA
GO:0006457 protein folding IEA
GO:0006805 xenobiotic metabolic process TAS
GO:0006986 response to unfolded protein NAS
GO:0007004 telomere maintenance via telomerase IDA
GO:0009651 response to salt stress IEA
GO:0019062 virion attachment to host cell IMP
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
GO:0031396 regulation of protein ubiquitination IDA
GO:0032092 positive regulation of protein binding IEA
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
GO:0032516 positive regulation of phosphoprotein phosphatase activity IDA
GO:0033160 positive regulation of protein import into nucleus, translocation IEA
GO:0035690 cellular response to drug IEA
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0042220 response to cocaine IEA
GO:0043312 neutrophil degranulation TAS
GO:0043524 negative regulation of neuron apoptotic process IEA
GO:0045429 positive regulation of nitric oxide biosynthetic process ISS
GO:0045597 positive regulation of cell differentiation IMP
GO:0045793 positive regulation of cell size IEA
GO:0050821 protein stabilization TAS
GO:0051131 chaperone-mediated protein complex assembly IDA
GO:0051973 positive regulation of telomerase activity IDA
GO:0060334 regulation of interferon-gamma-mediated signaling pathway IMP
GO:0060338 regulation of type I interferon-mediated signaling pathway IMP
GO:0071157 negative regulation of cell cycle arrest IMP
GO:0071353 cellular response to interleukin-4 IEA
GO:0071407 cellular response to organic cyclic compound IEA
GO:0071902 positive regulation of protein serine/threonine kinase activity IEA
GO:0097435 supramolecular fiber organization IMP
GO:1900034 regulation of cellular response to heat TAS
GO:1901389 negative regulation of transforming growth factor beta activation IDA
GO:1903660 negative regulation of complement-dependent cytotoxicity IEA
GO:1905323 telomerase holoenzyme complex assembly IDA
GO:2000010 positive regulation of protein localization to cell surface IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005739 mitochondrion IDA
GO:0005765 lysosomal membrane IEA
GO:0005829 cytosol TAS
GO:0008180 COP9 signalosome IDA
GO:0009986 cell surface IEA
GO:0016020 membrane IDA
GO:0016234 inclusion body IEA
GO:0016323 basolateral plasma membrane IEA
GO:0016324 apical plasma membrane IEA
GO:0031526 brush border membrane IEA
GO:0034751 aryl hydrocarbon receptor complex IDA
GO:0034774 secretory granule lumen TAS
GO:0042470 melanosome IEA
GO:0043234 protein complex IDA
GO:0070062 extracellular exosome IDA
GO:1904813 ficolin-1-rich granule lumen TAS
GO:1990913 sperm head plasma membrane IEA
GO:1990917 ooplasm IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005576 extracellular region GO:0005654 nucleoplasm 6.62e-72 7.68e-98
GO:0005634 nucleus GO:0005765 lysosomal membrane 3.45e-10 9.81e-32
GO:0005634 nucleus GO:0009986 cell surface 1.10e-44 1.49e-81
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0016324 apical plasma membrane 8.24e-09 4.92e-02
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0005765 lysosomal membrane 7.59e-07 1.29e-14
GO:0005654 nucleoplasm GO:0009986 cell surface 1.97e-37 5.46e-93
GO:0005654 nucleoplasm GO:0016020 membrane 5.76e-255 1.32e-206
GO:0005654 nucleoplasm GO:0016323 basolateral plasma membrane 7.74e-03 2.03e-05
GO:0005654 nucleoplasm GO:0016324 apical plasma membrane 3.23e-10 1.76e-23
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
GO:0005829 cytosol GO:0009986 cell surface 3.26e-22 6.81e-06
Interactor Also a MoonDB EMF protein
TRAF2_HUMAN No
FBXW5_HUMAN No
CSK21_HUMAN Yes: P68400 (MoonDB)
KAT5_HUMAN No
PCGF1_HUMAN No
SGTA_HUMAN No
KEAP1_HUMAN No
BLK_HUMAN No
KCC2A_HUMAN No
A0A0G2JHK4_HUMAN No
A9UEZ6_HUMAN No
AAPK1_HUMAN No
AAPK2_HUMAN No
ABL1_HUMAN Yes: P00519 (MoonDB)
ACD_HUMAN Yes: Q96AP0 (MoonDB)
ACK1_HUMAN No
ACTB_HUMAN No
ACV1B_HUMAN No
ACV1C_HUMAN No
AGO3_HUMAN No
AHSA1_HUMAN No
AKT2_HUMAN No
AKT3_HUMAN No
ALK_HUMAN No
ALPK1_HUMAN No
AMHR2_HUMAN No
ANC2_HUMAN No
ANPRB_HUMAN No
ARAF_HUMAN No
AREL1_HUMAN No
ARMC5_HUMAN No
ASB17_HUMAN No
ASB2_HUMAN No
ASB3_HUMAN No
ASB4_HUMAN No
ASB6_HUMAN No
ATF3_HUMAN No
AURKB_HUMAN No
AURKC_HUMAN No
AVR2B_HUMAN No
B4DE84_HUMAN No
B4DYC6_HUMAN No
BBX_HUMAN No
BMR1A_HUMAN No
BMX_HUMAN No
BRAF_HUMAN No
BRE1B_HUMAN No
BTK_HUMAN No
C9JYL6_HUMAN No
CAMKV_HUMAN No
CC117_HUMAN No
CD11A_HUMAN No
CD37L_HUMAN No
CDC37_HUMAN Yes: Q16543 (MoonDB)
CDK10_HUMAN No
CDK14_HUMAN No
CDK15_HUMAN No
CDK18_HUMAN No
CDK3_HUMAN No
CDK4_HUMAN No
CDK6_HUMAN Yes: Q00534 (MoonDB)
CDK7_HUMAN No
CDK9_HUMAN No
CEBPE_HUMAN No
CFLAR_HUMAN No
CHIP_HUMAN Yes: Q9UNE7 (MoonDB)
CHK1_HUMAN No
CHRD1_HUMAN No
CLIC4_HUMAN No
CLK2_HUMAN No
CLK3_HUMAN No
COPG2_HUMAN No
CP17A_HUMAN No
CSF1R_HUMAN No
CT194_HUMAN No
CTCFL_HUMAN No
CUL1_HUMAN No
CUL2_HUMAN No
CUL3_HUMAN No
CUL4A_HUMAN No
CUL4B_HUMAN No
CXXC1_HUMAN No
DAPK3_HUMAN No
DCLK2_HUMAN No
DDR2_HUMAN No
DDX11_HUMAN No
DDX24_HUMAN No
DET1_HUMAN No
DLX6_HUMAN No
DMPK_HUMAN No
DMRTA_HUMAN No
DTX4_HUMAN No
DYR1B_HUMAN No
DYRK2_HUMAN No
DYRK4_HUMAN No
E2AK1_HUMAN No
E2AK2_HUMAN No
E2AK4_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
EIPR1_HUMAN No
ENC1_HUMAN No
ENOA_HUMAN Yes: P06733 (MoonDB)
EPHA1_HUMAN No
EPHA2_HUMAN No
EPHA4_HUMAN No
EPHB1_HUMAN No
EPHB6_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
ERBB3_HUMAN Yes: P21860 (MoonDB)
ERBB4_HUMAN No
ERCC2_HUMAN No
ERR2_HUMAN No
ESR1_HUMAN Yes: P03372 (MoonDB)
F162A_HUMAN No
FAK1_HUMAN No
FAK2_HUMAN No
FANCC_HUMAN No
FASTK_HUMAN No
FBH1_HUMAN No
FBW1A_HUMAN No
FBW1B_HUMAN No
FBX10_HUMAN No
FBX24_HUMAN No
FBX25_HUMAN No
FBX27_HUMAN No
FBX28_HUMAN No
FBX34_HUMAN No
FBX38_HUMAN No
FBX3_HUMAN No
FBX40_HUMAN No
FBX4_HUMAN No
FBX6_HUMAN No
FBX9_HUMAN No
FBXL2_HUMAN No
FBXL3_HUMAN No
FBXL8_HUMAN No
FBXW2_HUMAN No
FBXW7_HUMAN No
FCSD2_HUMAN No
FER_HUMAN No
FES_HUMAN No
FGFR1_HUMAN No
FGFR3_HUMAN No
FGR_HUMAN No
FKBP4_HUMAN No
FKBP8_HUMAN No
FLNA_HUMAN Yes: P21333 (MoonDB)
FOXM1_HUMAN No
FOXP2_HUMAN No
FRK_HUMAN No
FX4L6_HUMAN No
FXL12_HUMAN No
FXL13_HUMAN No
FXL14_HUMAN No
FXL15_HUMAN No
FXL18_HUMAN No
FYN_HUMAN Yes: P06241 (MoonDB)
G2E3_HUMAN No
GAN_HUMAN No
GBB2_HUMAN No
GNAI2_HUMAN No
GNAL_HUMAN No
GNB5_HUMAN No
GRK4_HUMAN No
GRK6_HUMAN No
GRK7_HUMAN No
GSK3A_HUMAN No
GTD2A_HUMAN No
H0YE48_HUMAN No
HASP_HUMAN No
HCK_HUMAN No
HDAC6_HUMAN No
HECD3_HUMAN No
HERC4_HUMAN No
HERC6_HUMAN No
HES4_HUMAN No
HIF1A_HUMAN No
HIPK4_HUMAN No
HMGA1_HUMAN No
HP1B3_HUMAN No
HS90A_HUMAN Yes: P07900 (MoonDB)
HSF1_HUMAN Yes: Q00613 (MoonDB)
HSPB1_HUMAN Yes: P04792 (MoonDB)
ICK_HUMAN No
IGF1R_HUMAN No
IKKA_HUMAN No
IKKB_HUMAN No
IKKE_HUMAN No
ILK_HUMAN No
INSRR_HUMAN No
IRAK2_HUMAN No
IRAK3_HUMAN No
IRF2_HUMAN No
ISX_HUMAN No
ITBP2_HUMAN No
ITK_HUMAN No
JAK1_HUMAN No
KAPCB_HUMAN No
KBTB4_HUMAN No
KBTB7_HUMAN No
KC1A_HUMAN No
KC1E_HUMAN No
KCC1G_HUMAN No
KCC2B_HUMAN No
KCC2D_HUMAN No
KCC2G_HUMAN No
KCC4_HUMAN No
KCNA5_HUMAN No
KCNA6_HUMAN No
KCNG1_HUMAN No
KCNS3_HUMAN No
KCTD8_HUMAN No
KGP2_HUMAN No
KKCC1_HUMAN No
KKCC2_HUMAN No
KLH10_HUMAN No
KLH13_HUMAN No
KLH14_HUMAN No
KLH15_HUMAN No
KLH22_HUMAN No
KLH23_HUMAN No
KLH25_HUMAN No
KLH26_HUMAN No
KLH29_HUMAN No
KLH32_HUMAN No
KLH34_HUMAN No
KLH36_HUMAN No
KLH38_HUMAN No
KLHL1_HUMAN No
KLHL6_HUMAN No
KPCA_HUMAN No
KPCB_HUMAN No
KPCD1_HUMAN No
KPCD2_HUMAN No
KPCE_HUMAN No
KPCG_HUMAN No
KPCI_HUMAN No
KPCL_HUMAN No
KPCT_HUMAN No
KPCZ_HUMAN Yes: Q05513 (MoonDB)
KPSH1_HUMAN No
KPSH2_HUMAN No
KS6A1_HUMAN No
KS6A2_HUMAN No
KS6A3_HUMAN No
KS6A5_HUMAN No
KS6A6_HUMAN No
KS6B1_HUMAN No
KS6C1_HUMAN No
KSR1_HUMAN No
KSR2_HUMAN No
LAR4B_HUMAN No
LCK_HUMAN No
LG3BP_HUMAN No
LIMK1_HUMAN No
LIMK2_HUMAN No
LNX1_HUMAN Yes: Q8TBB1 (MoonDB)
LRSM1_HUMAN Yes: Q6UWE0 (MoonDB)
LYN_HUMAN No
M3K12_HUMAN No
M3K14_HUMAN No
M3K15_HUMAN No
M3K2_HUMAN No
M3K5_HUMAN No
M3K6_HUMAN No
M3K8_HUMAN No
M3K9_HUMAN No
M4K1_HUMAN No
M4K2_HUMAN No
M4K4_HUMAN No
MAFG_HUMAN No
MARH9_HUMAN No
MAST2_HUMAN No
MATK_HUMAN No
MAX_HUMAN No
MCR_HUMAN No
MDM4_HUMAN Yes: O15151 (MoonDB)
MERTK_HUMAN No
MINK1_HUMAN No
MK04_HUMAN No
MK06_HUMAN Yes: Q16659 (MoonDB)
MK07_HUMAN No
MK15_HUMAN No
MKNK1_HUMAN No
MKX_HUMAN No
MOS_HUMAN No
MP2K5_HUMAN No
MP2K7_HUMAN No
MUSK_HUMAN No
MYLK2_HUMAN No
MYLK3_HUMAN No
MYLK4_HUMAN No
MYO3B_HUMAN No
NAL12_HUMAN No
NEK11_HUMAN No
NEK8_HUMAN No
NEK9_HUMAN No
NFIC_HUMAN No
NFKB1_HUMAN No
NFRKB_HUMAN No
NHLC1_HUMAN No
NOD1_HUMAN No
NPHP4_HUMAN No
NR1H3_HUMAN No
NR1I2_HUMAN No
NR1I3_HUMAN No
NR2C2_HUMAN No
NR4A1_HUMAN Yes: P22736 (MoonDB)
NTRK1_HUMAN No
NTRK2_HUMAN No
NTRK3_HUMAN No
NUAK2_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
PADI4_HUMAN No
PAK6_HUMAN No
PASK_HUMAN Yes: Q96RG2 (MoonDB)
PCGF3_HUMAN No
PCGF6_HUMAN No
PDK1L_HUMAN Yes: Q8N165 (MoonDB)
PGFRB_HUMAN No
PHB_HUMAN No
PIM2_HUMAN No
PIM3_HUMAN No
PINK1_HUMAN No
PIWL1_HUMAN No
PIWL2_HUMAN No
PIWL4_HUMAN No
PKN1_HUMAN No
PKN2_HUMAN No
POGK_HUMAN No
POTE1_HUMAN Yes: Q9NUX5 (MoonDB)
PPARD_HUMAN No
PPARG_HUMAN Yes: P37231 (MoonDB)
PPP5_HUMAN No
PRAG1_HUMAN No
PRAME_HUMAN No
PRDM1_HUMAN No
PREB_HUMAN No
PRKN_HUMAN No
PRKX_HUMAN No
PRKY_HUMAN No
PRP19_HUMAN Yes: Q9UMS4 (MoonDB)
PRPK_HUMAN No
PTK6_HUMAN No
Q15850_HUMAN No
Q573B4_HUMAN No
Q59FP4_HUMAN No
Q59GL9_HUMAN No
Q5ULA9_HUMAN No
Q86WA0_HUMAN No
Q86WI5_HUMAN No
Q96II5_HUMAN No
Q9H4M8_HUMAN No
Q9NWG3_HUMAN No
Q9UMP2_HUMAN No
RAF1_HUMAN Yes: P04049 (MoonDB)
RAG1_HUMAN No
RAPSN_HUMAN No
RB40A_HUMAN No
RCBT1_HUMAN No
RCBT2_HUMAN No
RFWD3_HUMAN No
RGS11_HUMAN No
RGS6_HUMAN No
RGS7_HUMAN No
RGS9_HUMAN No
RHBT1_HUMAN No
RHBT2_HUMAN No
RIPK1_HUMAN No
RN111_HUMAN Yes: Q6ZNA4 (MoonDB)
RN19B_HUMAN No
RNF10_HUMAN No
RO52_HUMAN No
ROR2_HUMAN No
RPAP3_HUMAN No
RPC1_HUMAN No
RPKL1_HUMAN No
SETB1_HUMAN No
SF3B3_HUMAN No
SGK1_HUMAN No
SGK2_HUMAN No
SGK3_HUMAN No
SH3R2_HUMAN No
SIM2_HUMAN No
SKP2_HUMAN No
SLN11_HUMAN No
SOCS6_HUMAN No
SPSB1_HUMAN No
SPSB3_HUMAN No
SRBP1_HUMAN No
SRPK1_HUMAN Yes: Q96SB4 (MoonDB)
SRPK3_HUMAN No
ST32B_HUMAN No
ST32C_HUMAN No
ST38L_HUMAN No
STA13_HUMAN No
STAT1_HUMAN No
STAT2_HUMAN No
STK11_HUMAN No
STK38_HUMAN No
STYK1_HUMAN No
SYSM_HUMAN No
TAD2A_HUMAN No
TAF1D_HUMAN No
TAOK3_HUMAN No
TAU_HUMAN No
TBK1_HUMAN No
TBX22_HUMAN No
TCF25_HUMAN No
TEAD2_HUMAN No
TEBP_HUMAN No
TERF1_HUMAN No
TESK1_HUMAN No
TESK2_HUMAN No
TET3_HUMAN No
TFDP3_HUMAN No
THAP4_HUMAN No
TIE1_HUMAN No
TINF2_HUMAN Yes: Q9BSI4 (MoonDB)
TNAP3_HUMAN No
TNK1_HUMAN No
TNNT1_HUMAN No
TREX1_HUMAN No
TRI10_HUMAN No
TRI17_HUMAN No
TRI32_HUMAN No
TRI36_HUMAN No
TRI37_HUMAN No
TRI41_HUMAN Yes: Q8WV44 (MoonDB)
TRI49_HUMAN No
TRI56_HUMAN No
TRI73_HUMAN No
TRI74_HUMAN No
TRIM2_HUMAN No
TRIM7_HUMAN No
TSSK1_HUMAN No
TSSK2_HUMAN No
TSSK3_HUMAN No
TSSK6_HUMAN No
TYK2_HUMAN No
TYRO3_HUMAN No
UBP18_HUMAN No
UBP19_HUMAN No
UBP36_HUMAN No
UBP49_HUMAN No
UBP50_HUMAN No
UFO_HUMAN No
UN45B_HUMAN No
VGFR3_HUMAN No
VPS18_HUMAN No
VPS41_HUMAN No
WNK4_HUMAN No
WSB2_HUMAN No
WWP1_HUMAN Yes: Q9H0M0 (MoonDB)
YES_HUMAN No
Z3H7B_HUMAN No
ZBED4_HUMAN No
ZBT17_HUMAN No
ZBT20_HUMAN No
ZBT49_HUMAN No
ZN215_HUMAN No
ZN843_HUMAN No
ZNF74_HUMAN No
PMID Article Title
2469626 Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens.
2492519 Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II.
2768249 Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene.
3301534 Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family.
7588731 Mechanism of dimer formation of the 90-kDa heat-shock protein.
8180474 A cosmid clone at the D6S182 locus on human chromosome 6p12 contains the 90-kDa heat shock protein beta gene (HSP90 beta).
9150948 A two-dimensional gel database of human colon carcinoma proteins.
9482106 Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.
11230166 Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
14574404 The DNA sequence and analysis of human chromosome 6.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15159550 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.
15217611 Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
15358771 Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15581363 Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex.
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
16139798 Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.
16478993 GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.
16580629 SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis.
17081065 Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
18042044 Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.
18088087 Phosphoproteome of resting human platelets.
18239673 Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation.
18318008 Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
18400751 Conserved conformational changes in the ATPase cycle of human Hsp90.
18620420 Role of the cochaperone Tpr2 in Hsp90 chaperoning.
18669648 A quantitative atlas of mitotic phosphorylation.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19696785 Hsp90 is regulated by a switch point in the C-terminal domain.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20353823 Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.
20599762 Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21908771 The first identification of lysine malonylation substrates and its regulatory enzyme.
22022502 An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.
22828320 Investigation on PLK2 and PLK3 substrate recognition.
22843495 Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells.
22848402 Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23428871 Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.
23431407 Distinct roles of molecular chaperones HSP90alpha and HSP90beta in the biogenesis of KCNQ4 channels.
23585225 LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24613385 Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.
24681825 The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.
24880080 SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.
25486457 Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast.
25944712 N-terminome analysis of the human mitochondrial proteome.
25973397 Hsp90, the concertmaster: tuning transcription.
26517842 Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.
26991466 Review: The HSP90 molecular chaperone-an enigmatic ATPase.
27295069 Hsp90: Friends, clients and natural foes.
No results found.
Domain Name Domain ID Source
HHHU84 A29461 PIR
Hsp90_fam IPR001404 InterPro
HATPase_C IPR003594 InterPro
Heat_shock_protein_90_CS IPR019805 InterPro
Ribosomal_S5_D2-typ_fold IPR020568 InterPro
Hsp90_N IPR020575 InterPro
HATPase_C_sf IPR036890 InterPro
HSP90_C IPR037196 InterPro
HSP90 MF_00505 HAMAP
HSP90 PF00183 Pfam
HATPase_c PF02518 Pfam
Hsp90 PIRSF002583 PIRSF
HEATSHOCK90 PR00775 PRINTS
HSP90 PS00298 PROSITE
PTHR11528 PTHR11528 PANTHER
HATPase_c SM00387 SMART
SSF110942 SSF110942 SUPFAM
SSF54211 SSF54211 SUPFAM
SSF55874 SSF55874 SUPFAM
T46243 T46243 PIR
HATPase_c cd00075 CDD