Protein: Q9H0M0

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9H0M0 (Uniprot) WWP1_HUMAN WWP1 NEDD4-like E3 ubiquitin-protein ligase WWP1 human No
Uniprot: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 373 GO:0009056 catabolic process 48 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
48 GO:0044248 cellular catabolic process
48 GO:0070647 protein modification by small protein conjugation or removal
48 GO:0006508 proteolysis
48 GO:0060255 regulation of macromolecule metabolic process
48 GO:0007165 signal transduction
373 GO:0034645 cellular macromolecule biosynthetic process
373 GO:0006139 nucleobase-containing compound metabolic process
373 GO:0060255 regulation of macromolecule metabolic process
664 GO:0044267 cellular protein metabolic process
664 GO:0010467 gene expression
664 GO:0090304 nucleic acid metabolic process
664 GO:0060255 regulation of macromolecule metabolic process
664 GO:0007165 signal transduction
692 GO:0016070 RNA metabolic process
692 GO:0044271 cellular nitrogen compound biosynthetic process
692 GO:0010467 gene expression
692 GO:0019538 protein metabolic process
692 GO:2000112 regulation of cellular macromolecule biosynthetic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
48 GO:0031410 cytoplasmic vesicle
48 GO:0012505 endomembrane system
48 GO:0005634 nucleus
48 GO:0005886 plasma membrane
664 GO:0005829 cytosol
664 GO:0043232 intracellular non-membrane-bounded organelle
664 GO:0005634 nucleus
692 GO:0031981 nuclear lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007165 signal transduction NAS
GO:0007417 central nervous system development NAS
GO:0016567 protein ubiquitination TAS
GO:0034220 ion transmembrane transport TAS
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
GO:0045892 negative regulation of transcription, DNA-templated ISS
GO:0046718 viral entry into host cell TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000151 ubiquitin ligase complex NAS
GO:0005634 nucleus IEA
GO:0005737 cytoplasm IBA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000151 ubiquitin ligase complex GO:0005886 plasma membrane 2.77e-20 3.36e-26
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
PMID Article Title
9169421 Identification of novel human WW domain-containing proteins by cloning of ligand targets.
9647693 Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
11230166 Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
11779188 Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.
12450395 Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.
12535537 Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase.
15221015 Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).
15359284 The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16421571 DNA sequence and analysis of human chromosome 8.
18724389 The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11.
19343052 Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.
19561640 WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.
19580544 Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.
21191027 Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.
No results found.
Domain Name Domain ID Source
C2_dom IPR000008 InterPro
HECT_dom IPR000569 InterPro
WW_dom IPR001202 InterPro
E3_ub_ligase_SMURF1 IPR024928 InterPro
C2_domain_sf IPR035892 InterPro
Hect_E3_ubiquitin_ligase IPR035983 InterPro
WW_dom_sf IPR036020 InterPro
C2 PF00168 Pfam
WW PF00397 Pfam
HECT PF00632 Pfam
E3_ub_ligase_SMURF1 PIRSF001569 PIRSF
WW_DOMAIN_1 PS01159 PROSITE
C2 PS50004 PROSITE
WW_DOMAIN_2 PS50020 PROSITE
HECT PS50237 PROSITE
HECTc SM00119 SMART
C2 SM00239 SMART
WW SM00456 SMART
SSF49562 SSF49562 SUPFAM
SSF51045 SSF51045 SUPFAM
SSF56204 SSF56204 SUPFAM
HECTc cd00078 CDD
WW cd00201 CDD