Skip to main content
A Database of Extreme Multifunctional and Moonlighting Proteins
Main navigation
Home
Browse
Downloads
Help
About
Protein: Q16659
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q16659 (Uniprot)
MK06_HUMAN
MAPK6
Mitogen-activated protein kinase 6
human
No
Protein Function
Uniprot:
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and t
hen mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
more..
MoonDB Dissimilar Functions
Showing 1 to 2 of 2 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0007165
signal transduction
512
GO:0034641
cellular nitrogen compound metabolic process
595
,
789
4.22e-144
6.90e-18
GO:0007165
signal transduction
512
GO:0006725
cellular aromatic compound metabolic process
614
5.44e-126
5.27e-27
Copy
Excel
CSV
PDF
Previous
1
Next
MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 56 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
6
GO:0034645
cellular macromolecule biosynthetic process
6
GO:0010467
gene expression
6
GO:0090304
nucleic acid metabolic process
6
GO:0060255
regulation of macromolecule metabolic process
195
GO:0006468
protein phosphorylation
195
GO:0010468
regulation of gene expression
195
GO:0051246
regulation of protein metabolic process
195
GO:0007165
signal transduction
261
GO:0006355
regulation of transcription, DNA-templated
297
GO:0007165
signal transduction
Copy
Excel
CSV
PDF
Previous
1
2
3
4
5
6
Next
Cellular Components
Showing 1 to 10 of 28 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
6
GO:0043232
intracellular non-membrane-bounded organelle
6
GO:0005654
nucleoplasm
168
GO:0012505
endomembrane system
168
GO:0016021
integral component of membrane
195
GO:0005829
cytosol
195
GO:0005634
nucleus
261
GO:0031981
nuclear lumen
297
GO:0005634
nucleus
370
GO:0005829
cytosol
370
GO:0043232
intracellular non-membrane-bounded organelle
Copy
Excel
CSV
PDF
Previous
1
2
3
Next
Protein GO Annotations
Biological Processes
Showing 1 to 7 of 7 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000165
MAPK cascade
IEA
GO:0006468
protein phosphorylation
ISS
GO:0007049
cell cycle
IEA
GO:0007165
signal transduction
TAS
GO:0010468
regulation of gene expression
IBA
GO:0060999
positive regulation of dendritic spine development
IEA
GO:0071310
cellular response to organic substance
IBA
Copy
Excel
CSV
PDF
Previous
1
Next
Cellular Components
Showing 1 to 6 of 6 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005634
nucleus
IBA
GO:0005654
nucleoplasm
TAS
GO:0005737
cytoplasm
IBA
GO:0005829
cytosol
TAS
GO:0032156
septin cytoskeleton
IEA
GO:0043234
protein complex
IEA
Copy
Excel
CSV
PDF
Previous
1
Next
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 170 entries
Search:
Interactor
Also a MoonDB EMF protein
2AAA_HUMAN
No
AAKB1_HUMAN
No
ACTG_HUMAN
No
ACTY_HUMAN
No
AMPH_HUMAN
No
ANK3_HUMAN
No
ANKR2_HUMAN
No
APBA2_HUMAN
No
APC5_HUMAN
No
APOA1_HUMAN
No
Copy
Excel
CSV
PDF
Previous
1
2
3
4
5
…
17
Next
Publications Associated
Showing 1 to 10 of 14 entries
Search:
PMID
Article Title
7969157
Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.
8875998
Primary structure, expression and chromosomal locus of a human homolog of rat ERK3.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15226418
N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17344846
Patterns of somatic mutation in human cancer genomes.
17974005
The full-ORF clone resource of the German cDNA consortium.
18669648
A quantitative atlas of mitotic phosphorylation.
19054851
Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
19369195
Large-scale proteomics analysis of the human kinome.
Copy
Excel
CSV
PDF
Previous
1
2
Next
OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 13 entries
Search:
Domain Name
Domain ID
Source
A56352
A56352
PIR
ERK3ERK4MAPK
PR01771
PRINTS
Kinase-like_dom_sf
IPR011009
InterPro
MAPK_ERK3/4
IPR008350
InterPro
Pkinase
PF00069
Pfam
Prot_kinase_dom
IPR000719
InterPro
PROTEIN_KINASE_ATP
PS00107
PROSITE
Protein_kinase_ATP_BS
IPR017441
InterPro
PROTEIN_KINASE_DOM
PS50011
PROSITE
PROTEIN_KINASE_ST
PS00108
PROSITE
Copy
Excel
CSV
PDF
Previous
1
2
Next