Protein: Q16659 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q16659 (Uniprot)	MK06_HUMAN	MAPK6	Mitogen-activated protein kinase 6	human	No

Protein Function

Uniprot: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and t more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	512	GO:0034641	cellular nitrogen compound metabolic process	595, 789	4.22e-144	6.90e-18
GO:0007165	signal transduction	512	GO:0006725	cellular aromatic compound metabolic process	614	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
6	GO:0034645	cellular macromolecule biosynthetic process
6	GO:0010467	gene expression
6	GO:0090304	nucleic acid metabolic process
6	GO:0060255	regulation of macromolecule metabolic process
195	GO:0006468	protein phosphorylation
195	GO:0010468	regulation of gene expression
195	GO:0051246	regulation of protein metabolic process
195	GO:0007165	signal transduction
261	GO:0006355	regulation of transcription, DNA-templated
297	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
6	GO:0043232	intracellular non-membrane-bounded organelle
6	GO:0005654	nucleoplasm
168	GO:0012505	endomembrane system
168	GO:0016021	integral component of membrane
195	GO:0005829	cytosol
195	GO:0005634	nucleus
261	GO:0031981	nuclear lumen
297	GO:0005634	nucleus
370	GO:0005829	cytosol
370	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

Showing 1 to 7 of 7 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000165	MAPK cascade	IEA
GO:0006468	protein phosphorylation	ISS
GO:0007049	cell cycle	IEA
GO:0007165	signal transduction	TAS
GO:0010468	regulation of gene expression	IBA
GO:0060999	positive regulation of dendritic spine development	IEA
GO:0071310	cellular response to organic substance	IBA

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Cellular Components

Showing 1 to 6 of 6 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IBA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IBA
GO:0005829	cytosol	TAS
GO:0032156	septin cytoskeleton	IEA
GO:0043234	protein complex	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 170 entries

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Interactor	Also a MoonDB EMF protein
2AAA_HUMAN	No
AAKB1_HUMAN	No
ACTG_HUMAN	No
ACTY_HUMAN	No
AMPH_HUMAN	No
ANK3_HUMAN	No
ANKR2_HUMAN	No
APBA2_HUMAN	No
APC5_HUMAN	No
APOA1_HUMAN	No

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Publications Associated

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PMID	Article Title
7969157	Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.
8875998	Primary structure, expression and chromosomal locus of a human homolog of rat ERK3.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15226418	N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17344846	Patterns of somatic mutation in human cancer genomes.
17974005	The full-ORF clone resource of the German cDNA consortium.
18669648	A quantitative atlas of mitotic phosphorylation.
19054851	Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
19369195	Large-scale proteomics analysis of the human kinome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 13 entries

Search:

Domain Name	Domain ID	Source
A56352	A56352	PIR
ERK3ERK4MAPK	PR01771	PRINTS
Kinase-like_dom_sf	IPR011009	InterPro
MAPK_ERK3/4	IPR008350	InterPro
Pkinase	PF00069	Pfam
Prot_kinase_dom	IPR000719	InterPro
PROTEIN_KINASE_ATP	PS00107	PROSITE
Protein_kinase_ATP_BS	IPR017441	InterPro
PROTEIN_KINASE_DOM	PS50011	PROSITE
PROTEIN_KINASE_ST	PS00108	PROSITE

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