Protein: O00291 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O00291 (Uniprot)	HIP1_HUMAN	HIP1	Huntingtin-interacting protein 1	human	Yes

Protein Function

Uniprot: Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances and more..

Dissimilar Functions Manual Curation

Function 1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in a NMDA-dependent manner.

Function 2: Regulation of apoptosis, regulation of transcription. Condition: nuclear localization constitutive, enhanced upon androgen stimulation.

Publications (PMID): 16027218

MoonDB Network Modules

Biological Processes

Showing 1 to 4 of 4 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
134	GO:0044267	cellular protein metabolic process
134	GO:0060255	regulation of macromolecule metabolic process
134	GO:0007165	signal transduction
297	GO:0007165	signal transduction

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Cellular Components

Showing 1 to 6 of 6 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
134	GO:0005829	cytosol
134	GO:0005634	nucleus
297	GO:0005634	nucleus
447	GO:0005829	cytosol
447	GO:0043232	intracellular non-membrane-bounded organelle
447	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 18 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006351	transcription, DNA-templated	IEA
GO:0006355	regulation of transcription, DNA-templated	IEA
GO:0006915	apoptotic process	IDA
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA
GO:0007010	cytoskeleton organization	IEA
GO:0030100	regulation of endocytosis	NAS
GO:0030154	cell differentiation	IEA
GO:0042981	regulation of apoptotic process	IDA
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	IMP
GO:0048260	positive regulation of receptor-mediated endocytosis	IMP

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Cellular Components

Showing 1 to 10 of 14 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	TAS
GO:0005737	cytoplasm	IDA
GO:0005794	Golgi apparatus	IDA
GO:0005829	cytosol	TAS
GO:0005856	cytoskeleton	TAS
GO:0016020	membrane	TAS
GO:0030122	AP-2 adaptor complex	IDA
GO:0030136	clathrin-coated vesicle	IDA
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IEA
GO:0043231	intracellular membrane-bounded organelle	IDA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 5 of 5 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005794	Golgi apparatus	4.39e-25	2.14e-64
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0030136	clathrin-coated vesicle	6.14e-04	7.94e-24
GO:0005634	nucleus	GO:0098793	presynapse	3.45e-05	2.45e-27
GO:0005856	cytoskeleton	GO:0043231	intracellular membrane-bounded organelle	3.21e-14	3.53e-300

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All Protein Interactions

Showing 1 to 10 of 29 entries

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Interactor	Also a MoonDB EMF protein
CENPR_HUMAN	No
CFA53_HUMAN	No
CLH1_HUMAN	Yes: Q00610 (MoonDB)
CLH2_HUMAN	Yes: P53675 (MoonDB)
DAZP2_HUMAN	Yes: Q15038 (MoonDB)
DVL2_HUMAN	No
ECHP_HUMAN	No
F168A_HUMAN	No
FA49B_HUMAN	No
GLSL_HUMAN	No

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Publications Associated

Showing 1 to 10 of 24 entries

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PMID	Article Title
9140394	HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.
9147654	HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.
9616134	Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2).
11007801	Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.
11063258	HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.
11517213	HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.
11532990	The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.
11577110	Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins.
11788820	Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
11889126	HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 20 entries

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Domain Name	Domain ID	Source
ANTH	PF07651	Pfam
ANTH_dom	IPR011417	InterPro
ENTH	IPR013809	InterPro
ENTH	PS50942	PROSITE
ENTH	SM00273	SMART
ENTH_VHS	IPR008942	InterPro
HIP1	IPR030554	InterPro
HIP1_clath-bd	IPR032422	InterPro
HIP1_clath_bdg	PF16515	Pfam
I/LWEQ_dom_sf	IPR035964	InterPro

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