Protein: P53675

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P53675 (Uniprot) CLH2_HUMAN CLTCL1 Clathrin heavy chain 2 human Yes
Uniprot: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).
Dissimilar Functions Manual Curation

Function 1: Membrane trafficking, endocytosis.

Function 2: Involved in mitosis. Condition: interaction with microtubules, located at the mitotic spindle.

Publications (PMID): 15858577, 19509056

GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000278 mitotic cell cycle IDA
GO:0006886 intracellular protein transport IEA
GO:0006898 receptor-mediated endocytosis IDA
GO:0007165 signal transduction IEA
GO:0009653 anatomical structure morphogenesis TAS
GO:0042147 retrograde transport, endosome to Golgi IMP
GO:0046326 positive regulation of glucose import IMP
GO:0048268 clathrin coat assembly IEA
GO:0061024 membrane organization TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005769 early endosome IDA
GO:0005770 late endosome IDA
GO:0005802 trans-Golgi network IDA
GO:0005819 spindle IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IDA
GO:0005905 clathrin-coated pit IDA
GO:0016020 membrane IDA
GO:0030130 clathrin coat of trans-Golgi network vesicle IEA
GO:0030135 coated vesicle IDA
GO:0030136 clathrin-coated vesicle IDA
GO:0045334 clathrin-coated endocytic vesicle NAS
GO:0055037 recycling endosome IDA
GO:0070062 extracellular exosome IDA
GO:0071439 clathrin complex IEA
GO:0097443 sorting endosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005819 spindle GO:0005886 plasma membrane 2.71e-05 1.10e-14
Interactor Also a MoonDB EMF protein
HIP1_HUMAN Yes: O00291 (MoonDB)
SNX5_HUMAN No
PMID Article Title
8733128 Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome.
8733129 Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.
8844170 Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL).
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
No results found.
Domain Name Domain ID Source
G02757 G02757 PIR
Clathrin_H-chain/VPS_repeat IPR000547 InterPro
TPR-like_helical_dom_sf IPR011990 InterPro
Clathrin_H-chain_linker_core IPR015348 InterPro
ARM-type_fold IPR016024 InterPro
Clathrin_H-chain_N IPR016025 InterPro
Clathrin_heavy_chain IPR016341 InterPro
Clathrin_H-chain_propeller_rpt IPR022365 InterPro
Clathrin PF00637 Pfam
Clathrin_propel PF01394 Pfam
Clathrin-link PF09268 Pfam
Clathrin_H_chain PIRSF002290 PIRSF
CHCR PS50236 PROSITE
CLH SM00299 SMART
SSF48371 SSF48371 SUPFAM
SSF50989 SSF50989 SUPFAM
T09522 T09522 PIR