Protein: P53675 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P53675 (Uniprot)	CLH2_HUMAN	CLTCL1	Clathrin heavy chain 2	human	Yes

Protein Function

Uniprot: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).

Dissimilar Functions Manual Curation

Function 1: Membrane trafficking, endocytosis.

Function 2: Involved in mitosis. Condition: interaction with microtubules, located at the mitotic spindle.

Publications (PMID): 15858577, 19509056

MoonDB Network Modules

Biological Processes

No results found.

Cellular Components

No results found.

Protein GO Annotations

Biological Processes

Showing 1 to 9 of 9 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000278	mitotic cell cycle	IDA
GO:0006886	intracellular protein transport	IEA
GO:0006898	receptor-mediated endocytosis	IDA
GO:0007165	signal transduction	IEA
GO:0009653	anatomical structure morphogenesis	TAS
GO:0042147	retrograde transport, endosome to Golgi	IMP
GO:0046326	positive regulation of glucose import	IMP
GO:0048268	clathrin coat assembly	IEA
GO:0061024	membrane organization	TAS

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Cellular Components

Showing 1 to 10 of 16 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005769	early endosome	IDA
GO:0005770	late endosome	IDA
GO:0005802	trans-Golgi network	IDA
GO:0005819	spindle	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0005905	clathrin-coated pit	IDA
GO:0016020	membrane	IDA
GO:0030130	clathrin coat of trans-Golgi network vesicle	IEA
GO:0030135	coated vesicle	IDA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 1 of 1 entries

Search:

GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005819	spindle	GO:0005886	plasma membrane	2.71e-05	1.10e-14

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All Protein Interactions

Showing 1 to 2 of 2 entries

Search:

Interactor	Also a MoonDB EMF protein
HIP1_HUMAN	Yes: O00291 (MoonDB)
SNX5_HUMAN	No

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Publications Associated

Showing 1 to 5 of 5 entries

Search:

PMID	Article Title
8733128	Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome.
8733129	Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.
8844170	Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL).
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
20068231	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 17 entries

Search:

Domain Name	Domain ID	Source
ARM-type_fold	IPR016024	InterPro
CHCR	PS50236	PROSITE
Clathrin	PF00637	Pfam
Clathrin-link	PF09268	Pfam
Clathrin_H-chain/VPS_repeat	IPR000547	InterPro
Clathrin_H-chain_linker_core	IPR015348	InterPro
Clathrin_H-chain_N	IPR016025	InterPro
Clathrin_H-chain_propeller_rpt	IPR022365	InterPro
Clathrin_H_chain	PIRSF002290	PIRSF
Clathrin_heavy_chain	IPR016341	InterPro

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