Protein: P10276

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P10276 (Uniprot) RARA_HUMAN RARA Retinoic acid receptor alpha human No
Uniprot: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0006725 cellular aromatic compound metabolic process 345 5.44e-126 5.27e-27
GO:0007165 signal transduction 169 GO:0034641 cellular nitrogen compound metabolic process 789 4.22e-144 6.90e-18
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
345 GO:0006139 nucleobase-containing compound metabolic process
345 GO:0060255 regulation of macromolecule metabolic process
357 GO:0071310 cellular response to organic substance
357 GO:0031324 negative regulation of cellular metabolic process
357 GO:0010605 negative regulation of macromolecule metabolic process
357 GO:0051172 negative regulation of nitrogen compound metabolic process
357 GO:0031325 positive regulation of cellular metabolic process
357 GO:0010604 positive regulation of macromolecule metabolic process
357 GO:0051173 positive regulation of nitrogen compound metabolic process
357 GO:0009966 regulation of signal transduction
357 GO:0006357 regulation of transcription from RNA polymerase II promoter
490 GO:0031325 positive regulation of cellular metabolic process
490 GO:0010604 positive regulation of macromolecule metabolic process
490 GO:0051173 positive regulation of nitrogen compound metabolic process
490 GO:0009966 regulation of signal transduction
490 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0008219 cell death
535 GO:0044267 cellular protein metabolic process
535 GO:0071495 cellular response to endogenous stimulus
535 GO:0071310 cellular response to organic substance
535 GO:0010605 negative regulation of macromolecule metabolic process
535 GO:0045893 positive regulation of transcription, DNA-templated
535 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0007165 signal transduction
578 GO:0044267 cellular protein metabolic process
578 GO:0031325 positive regulation of cellular metabolic process
578 GO:0010604 positive regulation of macromolecule metabolic process
578 GO:0051173 positive regulation of nitrogen compound metabolic process
578 GO:0048584 positive regulation of response to stimulus
578 GO:0009966 regulation of signal transduction
578 GO:0006355 regulation of transcription, DNA-templated
672 GO:0034645 cellular macromolecule biosynthetic process
672 GO:0006139 nucleobase-containing compound metabolic process
672 GO:1901362 organic cyclic compound biosynthetic process
672 GO:0009889 regulation of biosynthetic process
672 GO:0010468 regulation of gene expression
789 GO:0044271 cellular nitrogen compound biosynthetic process
789 GO:0044267 cellular protein metabolic process
789 GO:0071310 cellular response to organic substance
789 GO:0031325 positive regulation of cellular metabolic process
789 GO:0010604 positive regulation of macromolecule metabolic process
789 GO:0051173 positive regulation of nitrogen compound metabolic process
789 GO:2000112 regulation of cellular macromolecule biosynthetic process
789 GO:0010468 regulation of gene expression
789 GO:0007165 signal transduction
867 GO:0044267 cellular protein metabolic process
867 GO:0071495 cellular response to endogenous stimulus
867 GO:0071310 cellular response to organic substance
867 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
867 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
169 GO:0005654 nucleoplasm
213 GO:0005634 nucleus
345 GO:0070013 intracellular organelle lumen
345 GO:0005634 nucleus
357 GO:0005654 nucleoplasm
490 GO:0005654 nucleoplasm
535 GO:0005829 cytosol
535 GO:0043232 intracellular non-membrane-bounded organelle
535 GO:0005654 nucleoplasm
578 GO:0005634 nucleus
672 GO:0031981 nuclear lumen
789 GO:0005654 nucleoplasm
867 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA
GO:0001657 ureteric bud development IEA
GO:0001843 neural tube closure IEA
GO:0001889 liver development IEA
GO:0002068 glandular epithelial cell development IEA
GO:0003148 outflow tract septum morphogenesis IEA
GO:0003417 growth plate cartilage development IEA
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0006468 protein phosphorylation IMP
GO:0007165 signal transduction IDA
GO:0007281 germ cell development IEA
GO:0007283 spermatogenesis IEA
GO:0007565 female pregnancy IEA
GO:0008284 positive regulation of cell proliferation IMP
GO:0008285 negative regulation of cell proliferation IEA
GO:0021766 hippocampus development IEA
GO:0030850 prostate gland development IEA
GO:0030853 negative regulation of granulocyte differentiation IDA
GO:0031076 embryonic camera-type eye development IEA
GO:0031641 regulation of myelination IEA
GO:0032355 response to estradiol IEA
GO:0032526 response to retinoic acid IMP
GO:0032689 negative regulation of interferon-gamma production IDA
GO:0032720 negative regulation of tumor necrosis factor production IDA
GO:0032736 positive regulation of interleukin-13 production IDA
GO:0032753 positive regulation of interleukin-4 production IDA
GO:0032754 positive regulation of interleukin-5 production IDA
GO:0033189 response to vitamin A IEA
GO:0034097 response to cytokine IEA
GO:0035264 multicellular organism growth IEA
GO:0043066 negative regulation of apoptotic process IEA
GO:0043277 apoptotic cell clearance IMP
GO:0043401 steroid hormone mediated signaling pathway IEA
GO:0045471 response to ethanol IEA
GO:0045630 positive regulation of T-helper 2 cell differentiation IDA
GO:0045666 positive regulation of neuron differentiation IEA
GO:0045787 positive regulation of cell cycle IMP
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP
GO:0045947 negative regulation of translational initiation IEA
GO:0048167 regulation of synaptic plasticity IEA
GO:0048384 retinoic acid receptor signaling pathway IMP
GO:0051099 positive regulation of binding IMP
GO:0055012 ventricular cardiac muscle cell differentiation IEA
GO:0060010 Sertoli cell fate commitment IEA
GO:0060173 limb development IEA
GO:0060324 face development IEA
GO:0060534 trachea cartilage development IEA
GO:0060591 chondroblast differentiation IEA
GO:0061037 negative regulation of cartilage development IEA
GO:0071222 cellular response to lipopolysaccharide IEA
GO:0071300 cellular response to retinoic acid IDA
GO:0071391 cellular response to estrogen stimulus IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol IDA
GO:0009986 cell surface IC
GO:0015629 actin cytoskeleton IDA
GO:0030425 dendrite IEA
GO:0043025 neuronal cell body IEA
GO:0048471 perinuclear region of cytoplasm IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000790 nuclear chromatin GO:0005737 cytoplasm 4.55e-08 5.17e-23
GO:0005634 nucleus GO:0009986 cell surface 1.10e-44 1.49e-81
GO:0005654 nucleoplasm GO:0009986 cell surface 1.97e-37 5.46e-93
GO:0005829 cytosol GO:0009986 cell surface 3.26e-22 6.81e-06
PMID Article Title
2175878 Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha).
2825025 A human retinoic acid receptor which belongs to the family of nuclear receptors.
2825036 Identification of a receptor for the morphogen retinoic acid.
8302850 PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.
8562957 The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.
9267036 Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
10337631 Genomic structure of the human retinoic acid receptor-alpha1 gene.
10567404 A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.
10698945 Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.
10882070 Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains.
11812818 Retinoic acid receptor alpha1 variants, RARalpha1DeltaB and RARalpha1DeltaBC, define a new class of nuclear receptor isoforms.
11971969 ERAP140, a conserved tissue-specific nuclear receptor coactivator.
12039952 Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.
12691149 Cytogenetics, FISH and RT-PCR analysis of acute promyelocytic leukemia: structure of the fusion point in a case lacking classic t(15;17) translocation.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15809060 Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation.
16179254 The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.
16417524 Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.
16606617 Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17455211 RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix.
19377461 GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.
19850744 Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity.
20215566 Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.
20543827 A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
22351778 Familial focal segmental glomerulosclerosis (FSGS)-linked alpha-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.
No results found.
Domain Name Domain ID Source
A29491 A29491 PIR
Nucl_hrmn_rcpt_lig-bd IPR000536 InterPro
Znf_hrmn_rcpt IPR001628 InterPro
Nuclear_hrmn_rcpt IPR001723 InterPro
Retinoic_acid_rcpt IPR003078 InterPro
Znf_NHR/GATA IPR013088 InterPro
NHR_like_dom_sf IPR035500 InterPro
Hormone_recep PF00104 Pfam
zf-C4 PF00105 Pfam
STROIDFINGER PR00047 PRINTS
STRDHORMONER PR00398 PRINTS
RETNOICACIDR PR01292 PRINTS
NUCLEAR_REC_DBD_1 PS00031 PROSITE
NUCLEAR_REC_DBD_2 PS51030 PROSITE
NR_LBD PS51843 PROSITE
ZnF_C4 SM00399 SMART
HOLI SM00430 SMART
SSF48508 SSF48508 SUPFAM