Protein: P19793

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P19793 (Uniprot) RXRA_HUMAN RXRA Retinoic acid receptor RXR-alpha human No
Uniprot: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0034641 cellular nitrogen compound metabolic process 245, 789 4.22e-144 6.90e-18
GO:0007165 signal transduction 169 GO:0006725 cellular aromatic compound metabolic process 345 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
42 GO:0031325 positive regulation of cellular metabolic process
42 GO:0010604 positive regulation of macromolecule metabolic process
42 GO:0051173 positive regulation of nitrogen compound metabolic process
42 GO:0006355 regulation of transcription, DNA-templated
42 GO:0007165 signal transduction
45 GO:0071495 cellular response to endogenous stimulus
45 GO:0071310 cellular response to organic substance
45 GO:0032270 positive regulation of cellular protein metabolic process
45 GO:0006468 protein phosphorylation
45 GO:0042325 regulation of phosphorylation
45 GO:0009966 regulation of signal transduction
122 GO:0016070 RNA metabolic process
122 GO:0044271 cellular nitrogen compound biosynthetic process
122 GO:0006464 cellular protein modification process
122 GO:0031324 negative regulation of cellular metabolic process
122 GO:0010605 negative regulation of macromolecule metabolic process
122 GO:0051172 negative regulation of nitrogen compound metabolic process
122 GO:2000112 regulation of cellular macromolecule biosynthetic process
122 GO:0010468 regulation of gene expression
122 GO:0019219 regulation of nucleobase-containing compound metabolic process
122 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
221 GO:0006464 cellular protein modification process
221 GO:0071310 cellular response to organic substance
221 GO:0031325 positive regulation of cellular metabolic process
221 GO:0010604 positive regulation of macromolecule metabolic process
221 GO:0051173 positive regulation of nitrogen compound metabolic process
221 GO:0006357 regulation of transcription from RNA polymerase II promoter
221 GO:0007165 signal transduction
245 GO:0044271 cellular nitrogen compound biosynthetic process
245 GO:0090304 nucleic acid metabolic process
245 GO:1901362 organic cyclic compound biosynthetic process
245 GO:2000112 regulation of cellular macromolecule biosynthetic process
245 GO:0019219 regulation of nucleobase-containing compound metabolic process
341 GO:0070887 cellular response to chemical stimulus
341 GO:0045893 positive regulation of transcription, DNA-templated
341 GO:0006357 regulation of transcription from RNA polymerase II promoter
345 GO:0006139 nucleobase-containing compound metabolic process
345 GO:0060255 regulation of macromolecule metabolic process
357 GO:0071310 cellular response to organic substance
357 GO:0031324 negative regulation of cellular metabolic process
357 GO:0010605 negative regulation of macromolecule metabolic process
357 GO:0051172 negative regulation of nitrogen compound metabolic process
357 GO:0031325 positive regulation of cellular metabolic process
357 GO:0010604 positive regulation of macromolecule metabolic process
357 GO:0051173 positive regulation of nitrogen compound metabolic process
357 GO:0009966 regulation of signal transduction
357 GO:0006357 regulation of transcription from RNA polymerase II promoter
367 GO:0010467 gene expression
367 GO:0007399 nervous system development
367 GO:0006139 nucleobase-containing compound metabolic process
367 GO:0019538 protein metabolic process
367 GO:0051128 regulation of cellular component organization
367 GO:0060255 regulation of macromolecule metabolic process
367 GO:0007165 signal transduction
465 GO:0031325 positive regulation of cellular metabolic process
465 GO:0010604 positive regulation of macromolecule metabolic process
465 GO:0051173 positive regulation of nitrogen compound metabolic process
465 GO:0006357 regulation of transcription from RNA polymerase II promoter
465 GO:0007165 signal transduction
535 GO:0008219 cell death
535 GO:0044267 cellular protein metabolic process
535 GO:0071495 cellular response to endogenous stimulus
535 GO:0071310 cellular response to organic substance
535 GO:0010605 negative regulation of macromolecule metabolic process
535 GO:0045893 positive regulation of transcription, DNA-templated
535 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0007165 signal transduction
578 GO:0044267 cellular protein metabolic process
578 GO:0031325 positive regulation of cellular metabolic process
578 GO:0010604 positive regulation of macromolecule metabolic process
578 GO:0051173 positive regulation of nitrogen compound metabolic process
578 GO:0048584 positive regulation of response to stimulus
578 GO:0009966 regulation of signal transduction
578 GO:0006355 regulation of transcription, DNA-templated
626 GO:0006915 apoptotic process
626 GO:0044267 cellular protein metabolic process
626 GO:0071310 cellular response to organic substance
626 GO:0051253 negative regulation of RNA metabolic process
626 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
626 GO:0010629 negative regulation of gene expression
626 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
626 GO:0010941 regulation of cell death
626 GO:0009966 regulation of signal transduction
626 GO:0009719 response to endogenous stimulus
672 GO:0034645 cellular macromolecule biosynthetic process
672 GO:0006139 nucleobase-containing compound metabolic process
672 GO:1901362 organic cyclic compound biosynthetic process
672 GO:0009889 regulation of biosynthetic process
672 GO:0010468 regulation of gene expression
789 GO:0044271 cellular nitrogen compound biosynthetic process
789 GO:0044267 cellular protein metabolic process
789 GO:0071310 cellular response to organic substance
789 GO:0031325 positive regulation of cellular metabolic process
789 GO:0010604 positive regulation of macromolecule metabolic process
789 GO:0051173 positive regulation of nitrogen compound metabolic process
789 GO:2000112 regulation of cellular macromolecule biosynthetic process
789 GO:0010468 regulation of gene expression
789 GO:0007165 signal transduction
823 GO:0044267 cellular protein metabolic process
823 GO:0071310 cellular response to organic substance
823 GO:0010629 negative regulation of gene expression
823 GO:0031325 positive regulation of cellular metabolic process
823 GO:0010628 positive regulation of gene expression
823 GO:0051173 positive regulation of nitrogen compound metabolic process
823 GO:0006357 regulation of transcription from RNA polymerase II promoter
823 GO:0007165 signal transduction
867 GO:0044267 cellular protein metabolic process
867 GO:0071495 cellular response to endogenous stimulus
867 GO:0071310 cellular response to organic substance
867 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
867 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
42 GO:0005829 cytosol
42 GO:0005654 nucleoplasm
45 GO:0005829 cytosol
45 GO:0031981 nuclear lumen
45 GO:0005886 plasma membrane
122 GO:0005829 cytosol
122 GO:0043232 intracellular non-membrane-bounded organelle
122 GO:0005654 nucleoplasm
162 GO:0005634 nucleus
169 GO:0005654 nucleoplasm
221 GO:0005829 cytosol
221 GO:0043232 intracellular non-membrane-bounded organelle
221 GO:0005654 nucleoplasm
245 GO:0005634 nucleus
341 GO:0005654 nucleoplasm
345 GO:0070013 intracellular organelle lumen
345 GO:0005634 nucleus
357 GO:0005654 nucleoplasm
367 GO:0005829 cytosol
367 GO:0070013 intracellular organelle lumen
367 GO:0005634 nucleus
411 GO:0005634 nucleus
465 GO:0005654 nucleoplasm
535 GO:0005829 cytosol
535 GO:0043232 intracellular non-membrane-bounded organelle
535 GO:0005654 nucleoplasm
578 GO:0005634 nucleus
626 GO:0005829 cytosol
626 GO:0005654 nucleoplasm
672 GO:0031981 nuclear lumen
789 GO:0005654 nucleoplasm
823 GO:0005829 cytosol
823 GO:0005654 nucleoplasm
867 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0001701 in utero embryonic development IEA
GO:0001893 maternal placenta development IEA
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0006766 vitamin metabolic process TAS
GO:0007566 embryo implantation IEA
GO:0008203 cholesterol metabolic process TAS
GO:0015721 bile acid and bile salt transport TAS
GO:0019048 modulation by virus of host morphology or physiology IDA
GO:0019216 regulation of lipid metabolic process TAS
GO:0032526 response to retinoic acid IMP
GO:0035357 peroxisome proliferator activated receptor signaling pathway IDA
GO:0043010 camera-type eye development IEA
GO:0043401 steroid hormone mediated signaling pathway IEA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0045994 positive regulation of translational initiation by iron IEA
GO:0048384 retinoic acid receptor signaling pathway IMP
GO:0051289 protein homotetramerization IDA
GO:0055010 ventricular cardiac muscle tissue morphogenesis IEA
GO:0055012 ventricular cardiac muscle cell differentiation IEA
GO:0060038 cardiac muscle cell proliferation IEA
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA
GO:0060687 regulation of branching involved in prostate gland morphogenesis IEA
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0043234 protein complex IDA
GO:0043235 receptor complex IDA
GO:0090575 RNA polymerase II transcription factor complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1310260 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.
2159111 Nuclear receptor that identifies a novel retinoic acid response pathway.
7746322 Structural determinants of nuclear receptor assembly on DNA direct repeats.
7760929 Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
7925381 NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix.
9267036 Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
9698548 High-resolution solution structure of the retinoid X receptor DNA-binding domain.
10195690 Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR.
10567404 A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.
10669605 Structural basis of RXR-DNA interactions.
10698945 Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.
10835357 Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid.
10882139 Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
10970886 Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.
11162439 Serine 27, a human retinoid X receptor alpha residue, phosphorylated by protein kinase A is essential for cyclicAMP-mediated downregulation of RXRalpha function.
11259580 PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
11698662 Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
11915042 Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity.
12039952 Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14981089 The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity.
15047147 ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.
15164053 DNA sequence and analysis of human chromosome 9.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15610733 The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.
16574651 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.
16912044 Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1.
17205979 Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function.
18619963 DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system.
18669648 A quantitative atlas of mitotic phosphorylation.
19786558 The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20215566 Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
28698609 Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia.
No results found.
Domain Name Domain ID Source
Retinoid-X_rcpt/HNF4 IPR000003 InterPro
Nucl_hrmn_rcpt_lig-bd IPR000536 InterPro
Znf_hrmn_rcpt IPR001628 InterPro
Nuclear_hrmn_rcpt IPR001723 InterPro
Znf_NHR/GATA IPR013088 InterPro
Nuc_recep-AF1 IPR021780 InterPro
NHR_like_dom_sf IPR035500 InterPro
Hormone_recep PF00104 Pfam
zf-C4 PF00105 Pfam
Nuc_recep-AF1 PF11825 Pfam
STROIDFINGER PR00047 PRINTS
STRDHORMONER PR00398 PRINTS
RETINOIDXR PR00545 PRINTS
NUCLEAR_REC_DBD_1 PS00031 PROSITE
NUCLEAR_REC_DBD_2 PS51030 PROSITE
NR_LBD PS51843 PROSITE
S09592 S09592 PIR
ZnF_C4 SM00399 SMART
HOLI SM00430 SMART
SSF48508 SSF48508 SUPFAM