Protein: P32189 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P32189 (Uniprot)	GLPK_HUMAN	GK	Glycerol kinase	human	Yes

Protein Function

Uniprot: Key enzyme in the regulation of glycerol uptake and metabolism.

Function 1: Glycerol kinase. Key enzyme in the regulation of glycerol uptake and metabolism.

Function 2: ATP-stimulated translocation protein. Binds to histones, interacts with porin or the voltage dependant anion channel. Lysosomal stabilization factor.

Publications (PMID): 15877277

MoonDB Network Modules

Biological Processes

No results found.

Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
411	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006071	glycerol metabolic process	IMP
GO:0006641	triglyceride metabolic process	IMP
GO:0016310	phosphorylation	IEA
GO:0019432	triglyceride biosynthetic process	TAS
GO:0019563	glycerol catabolic process	IEA
GO:0046167	glycerol-3-phosphate biosynthetic process	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005739	mitochondrion	IBA
GO:0005741	mitochondrial outer membrane	IEA
GO:0005829	cytosol	TAS
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AOXA_HUMAN	No
CLP1L_HUMAN	No
CP3A4_HUMAN	No
FBX28_HUMAN	No
GPDA_HUMAN	No
IF4G1_HUMAN	No
IPO13_HUMAN	No
NR4A1_HUMAN	Yes: P22736 (MoonDB)
OPLA_HUMAN	No
RXRA_HUMAN	Yes: P19793 (MoonDB)

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Publications Associated

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PMID	Article Title
7987308	The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons.
8401584	Genomic scanning for expressed sequences in Xp21 identifies the glycerol kinase gene.
8499898	Isolation of the human Xp21 glycerol kinase gene by positional cloning.
8499912	Cloning of the X-linked glycerol kinase deficiency gene and its identification by sequence comparison to the Bacillus subtilis homologue.
8651297	Mutations and phenotype in isolated glycerol kinase deficiency.
9719371	Clinical heterogeneity and novel mutations in the glycerol kinase gene in three families with isolated glycerol kinase deficiency.
10736265	Glycerol as a correlate of impaired glucose tolerance: dissection of a complex system by use of a simple genetic trait.
10851254	Five cases of isolated glycerol kinase deficiency, including two families: failure to find genotype:phenotype correlation.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

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OMIM Diseases Associated

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OMIM ID	Disease Name
307030	Glycerol kinase deficiency

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Protein Domains Associated

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Domain Name	Domain ID	Source
Carb_kinase_FGGY	IPR000577	InterPro
Carb_kinase_FGGY_C	IPR018485	InterPro
Carb_kinase_FGGY_CS	IPR018483	InterPro
Carb_kinase_FGGY_N	IPR018484	InterPro
FGGY_C	PF02782	Pfam
FGGY_KINASES_1	PS00933	PROSITE
FGGY_KINASES_2	PS00445	PROSITE
FGGY_N	PF00370	Pfam
GlpK	PIRSF000538	PIRSF
Glycerol_kin	IPR005999	InterPro

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