Protein: P14618 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P14618 (Uniprot)	KPYM_HUMAN	PKM	Pyruvate kinase PKM	human	Yes

Protein Function

Uniprot: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly in more..

Dissimilar Functions Manual Curation

Function 1: Pyruvate kinase, glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP. Condition: presence in a tetrameric form.

Function 2: Thyroid hormone-binding protein that regulates the transcriptional responses of the thiroid hormone receptor. Condition: presence in a monomeric form.

Publications (PMID): 15877277

MoonDB Dissimilar Functions

Showing 1 to 5 of 5 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	472	GO:0006928	movement of cell or subcellular component	496	1.95e-31	6.36e-195
GO:0007165	signal transduction	141, 187	GO:0034641	cellular nitrogen compound metabolic process	267	4.22e-144	6.90e-18
GO:0007165	signal transduction	141, 187	GO:0006139	nucleobase-containing compound metabolic process	472	1.10e-111	5.07e-25
GO:0009059	macromolecule biosynthetic process	391	GO:0006928	movement of cell or subcellular component	496	1.49e-13	8.46e-109
GO:0034641	cellular nitrogen compound metabolic process	267	GO:0006928	movement of cell or subcellular component	496	7.55e-40	5.63e-168

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 113 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
2	GO:0044267	cellular protein metabolic process
2	GO:0010467	gene expression
2	GO:0006139	nucleobase-containing compound metabolic process
2	GO:0060255	regulation of macromolecule metabolic process
2	GO:0007165	signal transduction
29	GO:0060255	regulation of macromolecule metabolic process
29	GO:0007165	signal transduction
42	GO:0031325	positive regulation of cellular metabolic process
42	GO:0010604	positive regulation of macromolecule metabolic process
42	GO:0051173	positive regulation of nitrogen compound metabolic process

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Cellular Components

Showing 1 to 10 of 45 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
2	GO:0005829	cytosol
2	GO:0005634	nucleus
29	GO:0005634	nucleus
42	GO:0005829	cytosol
42	GO:0005654	nucleoplasm
45	GO:0005829	cytosol
45	GO:0031981	nuclear lumen
45	GO:0005886	plasma membrane
138	GO:0005634	nucleus
141	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 14 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001666	response to hypoxia	IEA
GO:0001889	liver development	IEA
GO:0006754	ATP biosynthetic process	IEA
GO:0007584	response to nutrient	IEA
GO:0009629	response to gravity	IEA
GO:0012501	programmed cell death	IDA
GO:0014870	response to muscle inactivity	IEA
GO:0031100	animal organ regeneration	IEA
GO:0032869	cellular response to insulin stimulus	IBA
GO:0042866	pyruvate biosynthetic process	IEA

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Cellular Components

Showing 1 to 10 of 14 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005739	mitochondrion	IDA
GO:0005829	cytosol	TAS
GO:0005929	cilium	IEA
GO:0031012	extracellular matrix	IDA
GO:0031982	vesicle	IDA
GO:0034774	secretory granule lumen	TAS
GO:0043209	myelin sheath	IEA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 6 of 6 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005634	nucleus	GO:0031012	extracellular matrix	1.58e-13	4.18e-03
GO:0005634	nucleus	GO:0031982	vesicle	1.94e-54	3.27e-93
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005634	nucleus	GO:1903561	extracellular vesicle	1.85e-13	4.00e-27
GO:0005829	cytosol	GO:0031012	extracellular matrix	4.46e-06	5.18e-08

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All Protein Interactions

Showing 1 to 10 of 181 entries

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Interactor	Also a MoonDB EMF protein
AAPK2_HUMAN	No
ABL1_HUMAN	Yes: P00519 (MoonDB)
ABL2_HUMAN	Yes: P42684 (MoonDB)
ADDA_HUMAN	No
AKT1_HUMAN	No
AKT3_HUMAN	No
ALDOC_HUMAN	No
ALK_HUMAN	No
ANXA7_HUMAN	No
AP180_HUMAN	No

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Publications Associated

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PMID	Article Title
1854723	An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate.
2040271	Isolation and characterization of the human pyruvate kinase M gene.
2813362	Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase.
2854097	Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma.
9466265	Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.
12650930	Interaction between HERC1 and M2-type pyruvate kinase.
12665801	Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 20 entries

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Domain Name	Domain ID	Source
PK	PF00224	Pfam
PK_C	PF02887	Pfam
PTHR11817	PTHR11817	PANTHER
Pyr_Knase	IPR001697	InterPro
pyruv_kin	TIGR01064	TIGRFAMs
PYRUVATE_KINASE	PS00110	PROSITE
Pyruvate_Kinase	cd00288	CDD
PYRUVTKNASE	PR01050	PRINTS
Pyrv/PenolPyrv_Kinase-like_dom	IPR015813	InterPro
Pyrv_Knase-like_insert_dom_sf	IPR011037	InterPro

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