Protein: Q15154 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q15154 (Uniprot)	PCM1_HUMAN	PCM1	Pericentriolar material 1 protein	human	No

Protein Function

Uniprot: Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	142	GO:0033036	macromolecule localization	748	4.58e-19	9.70e-72
GO:0009059	macromolecule biosynthetic process	662	GO:0033036	macromolecule localization	748	2.32e-08	6.09e-30

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
3	GO:0022607	cellular component assembly
3	GO:0060255	regulation of macromolecule metabolic process
36	GO:0022607	cellular component assembly
142	GO:0090304	nucleic acid metabolic process
142	GO:0060255	regulation of macromolecule metabolic process
287	GO:0006464	cellular protein modification process
287	GO:0006355	regulation of transcription, DNA-templated
419	GO:0022607	cellular component assembly
540	GO:0022607	cellular component assembly
662	GO:0034645	cellular macromolecule biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
3	GO:0044430	cytoskeletal part
3	GO:0005829	cytosol
3	GO:0005634	nucleus
36	GO:0005829	cytosol
36	GO:0005815	microtubule organizing center
101	GO:0005829	cytosol
101	GO:0043232	intracellular non-membrane-bounded organelle
104	GO:0005829	cytosol
104	GO:0005815	microtubule organizing center
140	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000086	G2/M transition of mitotic cell cycle	TAS
GO:0001764	neuron migration	IEA
GO:0007098	centrosome cycle	IMP
GO:0010389	regulation of G2/M transition of mitotic cell cycle	TAS
GO:0022027	interkinetic nuclear migration	ISS
GO:0031122	cytoplasmic microtubule organization	IMP
GO:0034453	microtubule anchoring	ISS
GO:0034454	microtubule anchoring at centrosome	IBA
GO:0035176	social behavior	IEA
GO:0035735	intraciliary transport involved in cilium assembly	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000242	pericentriolar material	ISS
GO:0005737	cytoplasm	ISS
GO:0005813	centrosome	IDA
GO:0005814	centriole	IEA
GO:0005829	cytosol	TAS
GO:0016020	membrane	IDA
GO:0031965	nuclear membrane	IDA
GO:0034451	centriolar satellite	IDA
GO:0035869	ciliary transition zone	IDA
GO:0036064	ciliary basal body	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005814	centriole	GO:0016020	membrane	4.53e-05	3.65e-07

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ABCD3_HUMAN	No
ABI1_HUMAN	No
ABI2_HUMAN	Yes: Q9NYB9 (MoonDB)
ACOT9_HUMAN	No
ADIP_HUMAN	Yes: Q9Y2D8 (MoonDB)
AHI1_HUMAN	No
ANR26_HUMAN	No
ARP2_HUMAN	No
ASPP2_HUMAN	No
ATP5L_HUMAN	No

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Publications Associated

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PMID	Article Title
8120099	PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution.
9361024	Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
10980597	RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma.
12403812	Assembly of centrosomal proteins and microtubule organization depends on PCM-1.
14520415	Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15107855	The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.
15144186	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15184884	Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 5 of 5 entries

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Domain Name	Domain ID	Source
A54103	A54103	PIR
PCM1_C	IPR031446	InterPro
PCM1_C	PF15717	Pfam
Pericentriolar_Pcm1	IPR024138	InterPro
PTHR14164	PTHR14164	PANTHER

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