Protein: Q15154

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q15154 (Uniprot) PCM1_HUMAN PCM1 Pericentriolar material 1 protein human No
Uniprot: Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia.
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 142 GO:0033036 macromolecule localization 748 4.58e-19 9.70e-72
GO:0009059 macromolecule biosynthetic process 662 GO:0033036 macromolecule localization 748 2.32e-08 6.09e-30
Module ID (MoonGO) GO ID (BP) GO Name
3 GO:0022607 cellular component assembly
3 GO:0060255 regulation of macromolecule metabolic process
36 GO:0022607 cellular component assembly
142 GO:0090304 nucleic acid metabolic process
142 GO:0060255 regulation of macromolecule metabolic process
287 GO:0006464 cellular protein modification process
287 GO:0006355 regulation of transcription, DNA-templated
419 GO:0022607 cellular component assembly
540 GO:0022607 cellular component assembly
662 GO:0034645 cellular macromolecule biosynthetic process
662 GO:0044271 cellular nitrogen compound biosynthetic process
662 GO:0090304 nucleic acid metabolic process
677 GO:0022607 cellular component assembly
684 GO:0022402 cell cycle process
684 GO:0051640 organelle localization
686 GO:0060271 cilium assembly
748 GO:0008104 protein localization
806 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
3 GO:0044430 cytoskeletal part
3 GO:0005829 cytosol
3 GO:0005634 nucleus
36 GO:0005829 cytosol
36 GO:0005815 microtubule organizing center
101 GO:0005829 cytosol
101 GO:0043232 intracellular non-membrane-bounded organelle
104 GO:0005829 cytosol
104 GO:0005815 microtubule organizing center
140 GO:0043232 intracellular non-membrane-bounded organelle
142 GO:0005634 nucleus
185 GO:0005829 cytosol
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
226 GO:0005634 nucleus
256 GO:0043232 intracellular non-membrane-bounded organelle
256 GO:0005634 nucleus
287 GO:0005829 cytosol
287 GO:0043232 intracellular non-membrane-bounded organelle
287 GO:0031981 nuclear lumen
298 GO:0015630 microtubule cytoskeleton
411 GO:0005634 nucleus
417 GO:0005829 cytosol
417 GO:0043232 intracellular non-membrane-bounded organelle
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
495 GO:0043232 intracellular non-membrane-bounded organelle
495 GO:0005634 nucleus
540 GO:0005829 cytosol
540 GO:0043232 intracellular non-membrane-bounded organelle
540 GO:0005634 nucleus
561 GO:0043232 intracellular non-membrane-bounded organelle
631 GO:0044430 cytoskeletal part
631 GO:0005829 cytosol
631 GO:0015630 microtubule cytoskeleton
639 GO:0005634 nucleus
662 GO:0043232 intracellular non-membrane-bounded organelle
662 GO:0005634 nucleus
677 GO:0005813 centrosome
677 GO:0005829 cytosol
677 GO:0005634 nucleus
684 GO:0005829 cytosol
684 GO:0005815 microtubule organizing center
686 GO:0005813 centrosome
686 GO:0044441 ciliary part
686 GO:0005829 cytosol
686 GO:0044450 microtubule organizing center part
748 GO:0005815 microtubule organizing center
748 GO:0005634 nucleus
806 GO:0005634 nucleus
875 GO:0005856 cytoskeleton
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000086 G2/M transition of mitotic cell cycle TAS
GO:0001764 neuron migration IEA
GO:0007098 centrosome cycle IMP
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
GO:0022027 interkinetic nuclear migration ISS
GO:0031122 cytoplasmic microtubule organization IMP
GO:0034453 microtubule anchoring ISS
GO:0034454 microtubule anchoring at centrosome IBA
GO:0035176 social behavior IEA
GO:0035735 intraciliary transport involved in cilium assembly IMP
GO:0050768 negative regulation of neurogenesis ISS
GO:0060271 cilium assembly IMP
GO:0071539 protein localization to centrosome IMP
GO:0090316 positive regulation of intracellular protein transport IMP
GO:0097150 neuronal stem cell population maintenance IEA
GO:0097711 ciliary basal body-plasma membrane docking TAS
GO:1905515 non-motile cilium assembly IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000242 pericentriolar material ISS
GO:0005737 cytoplasm ISS
GO:0005813 centrosome IDA
GO:0005814 centriole IEA
GO:0005829 cytosol TAS
GO:0016020 membrane IDA
GO:0031965 nuclear membrane IDA
GO:0034451 centriolar satellite IDA
GO:0035869 ciliary transition zone IDA
GO:0036064 ciliary basal body IEA
GO:0043234 protein complex IDA
GO:0045177 apical part of cell IEA
GO:0097730 non-motile cilium IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005814 centriole GO:0016020 membrane 4.53e-05 3.65e-07
Interactor Also a MoonDB EMF protein
TFP11_HUMAN No
ASPP2_HUMAN No
K1C15_HUMAN No
NECA2_HUMAN No
ABI2_HUMAN Yes: Q9NYB9 (MoonDB)
CP135_HUMAN Yes: Q66GS9 (MoonDB)
HAUS1_HUMAN No
CC138_HUMAN No
MS18A_HUMAN No
GOGA2_HUMAN Yes: Q08379 (MoonDB)
ING5_HUMAN No
TXLNA_HUMAN No
PCBP3_HUMAN No
TNIP1_HUMAN No
NDK7_HUMAN No
IFT20_HUMAN No
CE57L_HUMAN No
CCHCR_HUMAN No
FBF1_HUMAN No
FTM_HUMAN No
CC112_HUMAN No
MCRS1_HUMAN No
CCD66_HUMAN No
CE104_HUMAN No
ABCD3_HUMAN No
ABI1_HUMAN No
ACOT9_HUMAN No
ADIP_HUMAN Yes: Q9Y2D8 (MoonDB)
AHI1_HUMAN No
ANR26_HUMAN No
ARP2_HUMAN No
ATP5L_HUMAN No
BAIP2_HUMAN No
BBS1_HUMAN No
BBS2_HUMAN No
BBS4_HUMAN No
BICD1_HUMAN No
BICD2_HUMAN No
BTF3_HUMAN No
C2CD3_HUMAN No
C2D1A_HUMAN No
C2D2A_HUMAN No
CAMP1_HUMAN No
CAMP2_HUMAN No
CC172_HUMAN No
CC85C_HUMAN No
CCD14_HUMAN No
CCD18_HUMAN No
CCD22_HUMAN No
CCD77_HUMAN No
CCD92_HUMAN No
CCNB1_HUMAN No
CCNB2_HUMAN No
CD123_HUMAN No
CE120_HUMAN Yes: Q8N960 (MoonDB)
CE128_HUMAN Yes: Q6ZU80 (MoonDB)
CE152_HUMAN No
CE162_HUMAN No
CE164_HUMAN No
CE170_HUMAN No
CE192_HUMAN No
CE290_HUMAN No
CE350_HUMAN No
CENPJ_HUMAN No
CEP55_HUMAN No
CEP63_HUMAN No
CEP72_HUMAN No
CEP85_HUMAN No
CEP89_HUMAN No
CEP95_HUMAN No
CEP97_HUMAN No
CK049_HUMAN No
CKAP2_HUMAN No
CKP2L_HUMAN No
CNO10_HUMAN No
CNTRL_HUMAN No
COMD2_HUMAN No
COMD4_HUMAN No
CP110_HUMAN No
CP131_HUMAN No
CSKP_HUMAN No
CSPP1_HUMAN No
CYH4_HUMAN No
DAPK3_HUMAN No
DDIT3_HUMAN No
DESP_HUMAN No
DIAP3_HUMAN No
E2F4_HUMAN No
ECM29_HUMAN No
EPS8_HUMAN No
EXOC4_HUMAN No
EXOC8_HUMAN No
FA81A_HUMAN No
FOPNL_HUMAN No
FR1OP_HUMAN No
GBRAP_HUMAN Yes: O95166 (MoonDB)
GNAO_HUMAN No
GPTC1_HUMAN No
HAP1_HUMAN No
HAUS2_HUMAN No
HAUS3_HUMAN No
HAUS4_HUMAN No
HAUS5_HUMAN No
HAUS6_HUMAN No
HAUS7_HUMAN No
HAUS8_HUMAN No
IBTK_HUMAN No
IDH3B_HUMAN No
IFT22_HUMAN No
IFT57_HUMAN No
IFT74_HUMAN No
IFT81_HUMAN No
IQCB1_HUMAN No
K1328_HUMAN No
K1C19_HUMAN No
K1C24_HUMAN No
KC1D_HUMAN No
KC1E_HUMAN No
KIF14_HUMAN No
KIF7_HUMAN No
KIZ_HUMAN No
KPYM_HUMAN Yes: P14618 (MoonDB)
LCA5_HUMAN No
LRC49_HUMAN No
LRCC1_HUMAN No
LUZP1_HUMAN No
M18BP_HUMAN No
MA7D3_HUMAN No
MAGD1_HUMAN No
MCM10_HUMAN No
MED29_HUMAN No
MED4_HUMAN No
MIB1_HUMAN No
MIPT3_HUMAN No
MOONR_HUMAN No
MPP9_HUMAN No
MYO9A_HUMAN No
NAV1_HUMAN No
NCK5L_HUMAN No
NDC80_HUMAN No
NEB2_HUMAN No
NEDD1_HUMAN No
NINL_HUMAN No
NIN_HUMAN No
NOL11_HUMAN No
NUF2_HUMAN No
ODF2L_HUMAN No
ODFP2_HUMAN No
OFD1_HUMAN No
PHOCN_HUMAN No
PIBF1_HUMAN No
PKN2_HUMAN No
PLK1_HUMAN Yes: P53350 (MoonDB)
POC5_HUMAN No
RAE1L_HUMAN No
RB6I2_HUMAN No
RBP1_HUMAN No
RINT1_HUMAN No
RIR2_HUMAN No
RPGR1_HUMAN No
SAS6_HUMAN No
SAV1_HUMAN No
SCLT1_HUMAN No
SDCG3_HUMAN No
SEBP2_HUMAN No
SEP12_HUMAN No
SKAP_HUMAN No
SMG5_HUMAN No
SMG7_HUMAN No
SPA24_HUMAN No
SPAS2_HUMAN No
SPC24_HUMAN No
SPICE_HUMAN Yes: Q8N0Z3 (MoonDB)
SRGP2_HUMAN No
STAU1_HUMAN No
STIL_HUMAN No
STRN4_HUMAN No
TANC1_HUMAN No
TBC31_HUMAN No
TCHP_HUMAN No
TEX9_HUMAN No
TPGS1_HUMAN No
TTC12_HUMAN No
TTF2_HUMAN No
TTK_HUMAN No
TTLL4_HUMAN No
TTLL5_HUMAN No
TXLNG_HUMAN No
WASC3_HUMAN No
WDR83_HUMAN No
WRP73_HUMAN No
XRN1_HUMAN Yes: Q8IZH2 (MoonDB)
Z280C_HUMAN No
PMID Article Title
8120099 PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution.
9361024 Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
10980597 RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma.
12403812 Assembly of centrosomal proteins and microtubule organization depends on PCM-1.
14520415 Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15107855 The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.
15144186 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15184884 Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15659651 Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.
15805263 The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2.
16034466 PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation.
16091753 The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene.
16270321 Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival.
16291865 Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.
16421571 DNA sequence and analysis of human chromosome 8.
16424865 A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma.
16769584 A combination of cytomorphology, cytogenetic analysis, fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction for establishing clonality in cases of persisting hypereosinophilia.
16943179 Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20551181 Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein.
20719959 Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24089205 Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.
24121310 A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24816561 Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability.
25074808 Proteomic analysis of mammalian sperm cells identifies new components of the centrosome.
25944712 N-terminome analysis of the human mitochondrial proteome.
26643951 OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome.
No results found.
Domain Name Domain ID Source
A54103 A54103 PIR
Pericentriolar_Pcm1 IPR024138 InterPro
PCM1_C IPR031446 InterPro
PCM1_C PF15717 Pfam
PTHR14164 PTHR14164 PANTHER