Protein: Q8IZH2

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8IZH2 (Uniprot) XRN1_HUMAN XRN1 5'-3' exoribonuclease 1 human No
Uniprot: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 27, 405 GO:0033036 macromolecule localization 748 4.58e-19 9.70e-72
GO:0034641 cellular nitrogen compound metabolic process 180 GO:0033036 macromolecule localization 748 4.14e-25 1.17e-53
GO:0044260 cellular macromolecule metabolic process 203, 564 GO:0033036 macromolecule localization 748 4.56e-06 3.25e-28
GO:0006725 cellular aromatic compound metabolic process 239 GO:0033036 macromolecule localization 748 1.29e-20 6.46e-74
GO:0019538 protein metabolic process 304, 383, 665 GO:0016070 RNA metabolic process 719 5.15e-08 2.82e-13
GO:0043170 macromolecule metabolic process 310, 412 GO:0033036 macromolecule localization 748 2.48e-08 1.95e-27
GO:0036211 protein modification process 425 GO:0016070 RNA metabolic process 719 5.81e-04 8.44e-05
GO:0009059 macromolecule biosynthetic process 557 GO:0033036 macromolecule localization 748 2.32e-08 6.09e-30
GO:0016070 RNA metabolic process 719 GO:0033036 macromolecule localization 748 2.39e-09 2.36e-89
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
3 GO:0022607 cellular component assembly
3 GO:0060255 regulation of macromolecule metabolic process
27 GO:0090304 nucleic acid metabolic process
27 GO:0060255 regulation of macromolecule metabolic process
29 GO:0060255 regulation of macromolecule metabolic process
29 GO:0007165 signal transduction
180 GO:0044271 cellular nitrogen compound biosynthetic process
180 GO:0070887 cellular response to chemical stimulus
180 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0031325 positive regulation of cellular metabolic process
180 GO:0010604 positive regulation of macromolecule metabolic process
180 GO:2000112 regulation of cellular macromolecule biosynthetic process
180 GO:0010468 regulation of gene expression
203 GO:0016070 RNA metabolic process
203 GO:0010468 regulation of gene expression
239 GO:0006139 nucleobase-containing compound metabolic process
304 GO:0044267 cellular protein metabolic process
304 GO:0007165 signal transduction
310 GO:0019538 protein metabolic process
325 GO:0006355 regulation of transcription, DNA-templated
383 GO:0044267 cellular protein metabolic process
383 GO:0006355 regulation of transcription, DNA-templated
405 GO:0090304 nucleic acid metabolic process
405 GO:0060255 regulation of macromolecule metabolic process
405 GO:0019219 regulation of nucleobase-containing compound metabolic process
412 GO:0019538 protein metabolic process
412 GO:0060255 regulation of macromolecule metabolic process
419 GO:0022607 cellular component assembly
425 GO:0006464 cellular protein modification process
557 GO:0034645 cellular macromolecule biosynthetic process
557 GO:0044265 cellular macromolecule catabolic process
557 GO:0044271 cellular nitrogen compound biosynthetic process
557 GO:0035556 intracellular signal transduction
557 GO:0016071 mRNA metabolic process
557 GO:0010629 negative regulation of gene expression
557 GO:0031325 positive regulation of cellular metabolic process
557 GO:0051247 positive regulation of protein metabolic process
557 GO:0051252 regulation of RNA metabolic process
557 GO:0009894 regulation of catabolic process
557 GO:0031326 regulation of cellular biosynthetic process
557 GO:0010556 regulation of macromolecule biosynthetic process
557 GO:0031399 regulation of protein modification process
564 GO:0016070 RNA metabolic process
564 GO:0034645 cellular macromolecule biosynthetic process
564 GO:0044271 cellular nitrogen compound biosynthetic process
564 GO:0044267 cellular protein metabolic process
564 GO:0009892 negative regulation of metabolic process
564 GO:0010468 regulation of gene expression
665 GO:0044267 cellular protein metabolic process
719 GO:0006401 RNA catabolic process
719 GO:0016071 mRNA metabolic process
719 GO:0010629 negative regulation of gene expression
719 GO:0019219 regulation of nucleobase-containing compound metabolic process
748 GO:0008104 protein localization
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
3 GO:0044430 cytoskeletal part
3 GO:0005829 cytosol
3 GO:0005634 nucleus
27 GO:0031981 nuclear lumen
29 GO:0005634 nucleus
30 GO:0005829 cytosol
30 GO:0043232 intracellular non-membrane-bounded organelle
148 GO:0005829 cytosol
162 GO:0005634 nucleus
180 GO:0005829 cytosol
180 GO:0070013 intracellular organelle lumen
180 GO:0044428 nuclear part
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
203 GO:0070013 intracellular organelle lumen
203 GO:0005634 nucleus
226 GO:0005634 nucleus
239 GO:0043232 intracellular non-membrane-bounded organelle
239 GO:0031981 nuclear lumen
310 GO:0005829 cytosol
310 GO:0005634 nucleus
325 GO:0005829 cytosol
325 GO:0043232 intracellular non-membrane-bounded organelle
325 GO:0005654 nucleoplasm
383 GO:0070013 intracellular organelle lumen
383 GO:0044428 nuclear part
405 GO:0005829 cytosol
405 GO:0043232 intracellular non-membrane-bounded organelle
405 GO:0070013 intracellular organelle lumen
405 GO:0005634 nucleus
412 GO:0005829 cytosol
412 GO:0005634 nucleus
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
425 GO:0005634 nucleus
495 GO:0043232 intracellular non-membrane-bounded organelle
495 GO:0005634 nucleus
557 GO:0005829 cytosol
557 GO:0044421 extracellular region part
557 GO:0005654 nucleoplasm
557 GO:0031982 vesicle
564 GO:0005829 cytosol
564 GO:0070013 intracellular organelle lumen
564 GO:0005634 nucleus
631 GO:0044430 cytoskeletal part
631 GO:0005829 cytosol
631 GO:0015630 microtubule cytoskeleton
633 GO:0005829 cytosol
633 GO:0031982 vesicle
665 GO:0043232 intracellular non-membrane-bounded organelle
665 GO:0005634 nucleus
671 GO:0005829 cytosol
671 GO:0070013 intracellular organelle lumen
671 GO:0005634 nucleus
719 GO:0005829 cytosol
719 GO:0043232 intracellular non-membrane-bounded organelle
719 GO:0005634 nucleus
748 GO:0005815 microtubule organizing center
748 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000956 nuclear-transcribed mRNA catabolic process IMP
GO:0016075 rRNA catabolic process IMP
GO:0017148 negative regulation of translation IEA
GO:0032211 negative regulation of telomere maintenance via telomerase IC
GO:0033574 response to testosterone IEA
GO:0043488 regulation of mRNA stability TAS
GO:0071028 nuclear mRNA surveillance IMP
GO:0071044 histone mRNA catabolic process IMP
GO:0071409 cellular response to cycloheximide IEA
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic ISS
GO:1905795 cellular response to puromycin IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000932 P-body IEA
GO:0005634 nucleus IEA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IDA
GO:0016020 membrane IDA
GO:0030425 dendrite IEA
GO:0043025 neuronal cell body IEA
GO:0045202 synapse IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000932 P-body GO:0005886 plasma membrane 1.99e-02 6.98e-24
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0045202 synapse 1.10e-08 8.94e-15
PMID Article Title
9802570 Cloning and characterization of human Sep1 (hSEP1) gene and cytoplasmic localization of its product.
12426100 The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma.
12515382 The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.
14527413 Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.
14580940 Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15687258 Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.
17974005 The full-ORF clone resource of the German cDNA consortium.
18172165 Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
21269460 Initial characterization of the human central proteome.
21876179 Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation.
23125361 The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23756462 Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
Put_53exo IPR004859 InterPro
5_3_exoribonuclease_1 IPR016494 InterPro
5_3_exoribonuclease IPR027073 InterPro
PIN-like_dom_sf IPR029060 InterPro
XRN_N PF03159 Pfam
Exonuclease_Xnr1 PIRSF006743 PIRSF
PTHR12341 PTHR12341 PANTHER
T43461 T43461 PIR