Protein: Q8IZH2 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8IZH2 (Uniprot)	XRN1_HUMAN	XRN1	5'-3' exoribonuclease 1	human	No

Protein Function

Uniprot: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replica more..

MoonDB Dissimilar Functions

Showing 1 to 9 of 9 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	27, 405	GO:0033036	macromolecule localization	748	4.58e-19	9.70e-72
GO:0006725	cellular aromatic compound metabolic process	239	GO:0033036	macromolecule localization	748	1.29e-20	6.46e-74
GO:0009059	macromolecule biosynthetic process	557	GO:0033036	macromolecule localization	748	2.32e-08	6.09e-30
GO:0016070	RNA metabolic process	719	GO:0033036	macromolecule localization	748	2.39e-09	2.36e-89
GO:0019538	protein metabolic process	304, 383, 665	GO:0016070	RNA metabolic process	719	5.15e-08	2.82e-13
GO:0034641	cellular nitrogen compound metabolic process	180	GO:0033036	macromolecule localization	748	4.14e-25	1.17e-53
GO:0036211	protein modification process	425	GO:0016070	RNA metabolic process	719	5.81e-04	8.44e-05
GO:0043170	macromolecule metabolic process	310, 412	GO:0033036	macromolecule localization	748	2.48e-08	1.95e-27
GO:0044260	cellular macromolecule metabolic process	203, 564	GO:0033036	macromolecule localization	748	4.56e-06	3.25e-28

Previous1Next

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 54 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
3	GO:0022607	cellular component assembly
3	GO:0060255	regulation of macromolecule metabolic process
27	GO:0090304	nucleic acid metabolic process
27	GO:0060255	regulation of macromolecule metabolic process
29	GO:0060255	regulation of macromolecule metabolic process
29	GO:0007165	signal transduction
180	GO:0044271	cellular nitrogen compound biosynthetic process
180	GO:0070887	cellular response to chemical stimulus
180	GO:0006139	nucleobase-containing compound metabolic process
180	GO:0031325	positive regulation of cellular metabolic process

Previous1 2 3 4 5 6Next

Cellular Components

Showing 1 to 10 of 59 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
3	GO:0044430	cytoskeletal part
3	GO:0005829	cytosol
3	GO:0005634	nucleus
27	GO:0031981	nuclear lumen
29	GO:0005634	nucleus
30	GO:0005829	cytosol
30	GO:0043232	intracellular non-membrane-bounded organelle
148	GO:0005829	cytosol
162	GO:0005634	nucleus
180	GO:0005829	cytosol

Previous1 2 3 4 5 6Next

Protein GO Annotations

Biological Processes

Showing 1 to 10 of 11 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000956	nuclear-transcribed mRNA catabolic process	IMP
GO:0016075	rRNA catabolic process	IMP
GO:0017148	negative regulation of translation	IEA
GO:0032211	negative regulation of telomere maintenance via telomerase	IC
GO:0033574	response to testosterone	IEA
GO:0043488	regulation of mRNA stability	TAS
GO:0071028	nuclear mRNA surveillance	IMP
GO:0071044	histone mRNA catabolic process	IMP
GO:0071409	cellular response to cycloheximide	IEA
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	ISS

Previous1 2Next

Cellular Components

Showing 1 to 8 of 8 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000932	P-body	IEA
GO:0005634	nucleus	IEA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0016020	membrane	IDA
GO:0030425	dendrite	IEA
GO:0043025	neuronal cell body	IEA
GO:0045202	synapse	IEA

Previous1Next

Dissimilar Cellular Components (PrOnto)

Showing 1 to 4 of 4 entries

Search:

GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000932	P-body	GO:0005886	plasma membrane	1.99e-02	6.98e-24
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0045202	synapse	1.10e-08	8.94e-15

Previous1Next

All Protein Interactions

Showing 1 to 10 of 72 entries

Search:

Interactor	Also a MoonDB EMF protein
ADIP_HUMAN	Yes: Q9Y2D8 (MoonDB)
ALDOA_HUMAN	No
ANGL6_HUMAN	No
AP1G2_HUMAN	No
AT5G2_HUMAN	No
B3GT6_HUMAN	No
BAG6_HUMAN	No
C1GLT_HUMAN	No
C2D2A_HUMAN	No
CATB_HUMAN	No

Previous1 2 3 4 5…8Next

Publications Associated

Showing 1 to 10 of 17 entries

Search:

PMID	Article Title
9802570	Cloning and characterization of human Sep1 (hSEP1) gene and cytoplasmic localization of its product.
12426100	The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma.
12515382	The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.
14527413	Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.
14580940	Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15687258	Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.
17974005	The full-ORF clone resource of the German cDNA consortium.
18172165	Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.

Previous1 2Next

OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 8 of 8 entries

Search:

Domain Name	Domain ID	Source
5_3_exoribonuclease	IPR027073	InterPro
5_3_exoribonuclease_1	IPR016494	InterPro
Exonuclease_Xnr1	PIRSF006743	PIRSF
PIN-like_dom_sf	IPR029060	InterPro
PTHR12341	PTHR12341	PANTHER
Put_53exo	IPR004859	InterPro
T43461	T43461	PIR
XRN_N	PF03159	Pfam

Previous1Next