Protein: Q15477 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q15477 (Uniprot)	SKIV2_HUMAN	SKIV2L	Helicase SKI2W	human	No

Protein Function

Uniprot: Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).

MoonDB Dissimilar Functions

Showing 1 to 1 of 1 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006464	cellular protein modification process	375	GO:0016070	RNA metabolic process	719	5.81e-04	8.44e-05

Previous1Next

MoonDB Network Modules

Biological Processes

Showing 1 to 8 of 8 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
375	GO:0070647	protein modification by small protein conjugation or removal
375	GO:0060255	regulation of macromolecule metabolic process
719	GO:0006401	RNA catabolic process
719	GO:0016071	mRNA metabolic process
719	GO:0010629	negative regulation of gene expression
719	GO:0019219	regulation of nucleobase-containing compound metabolic process
859	GO:0010467	gene expression
859	GO:0090304	nucleic acid metabolic process

Previous1Next

Cellular Components

Showing 1 to 6 of 6 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
375	GO:0005829	cytosol
375	GO:0005634	nucleus
719	GO:0005829	cytosol
719	GO:0043232	intracellular non-membrane-bounded organelle
719	GO:0005634	nucleus
859	GO:0005634	nucleus

Previous1Next

Protein GO Annotations

Biological Processes

Showing 1 to 2 of 2 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	TAS
GO:0070478	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	IBA

Previous1Next

Cellular Components

Showing 1 to 3 of 3 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IEA
GO:0005829	cytosol	TAS
GO:0055087	Ski complex	IDA

Previous1Next

Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 12 entries

Search:

Interactor	Also a MoonDB EMF protein
AAPK2_HUMAN	No
CACB3_HUMAN	No
CD11A_HUMAN	No
CDKL5_HUMAN	No
EXOS4_HUMAN	Yes: Q9NPD3 (MoonDB)
EXOSX_HUMAN	No
GLT13_HUMAN	No
MPPA_HUMAN	No
RSMB_HUMAN	No
TSSK2_HUMAN	No

Previous1 2Next

Publications Associated

Showing 1 to 10 of 19 entries

Search:

PMID	Article Title
7610041	Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family.
7759100	Identification and characterization of a human cDNA homologous to yeast SKI2.
8812450	Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B).
14574404	The DNA sequence and analysis of human chromosome 6.
16024656	The human PAF complex coordinates transcription with events downstream of RNA synthesis.
16959974	The consensus coding sequences of human breast and colorectal cancers.
16964243	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18088087	Phosphoproteome of resting human platelets.
18669648	A quantitative atlas of mitotic phosphorylation.

Previous1 2Next

OMIM Diseases Associated

Showing 1 to 1 of 1 entries

Search:

OMIM ID	Disease Name
614602	Trichohepatoenteric syndrome 2

Previous1Next

Protein Domains Associated

Showing 1 to 10 of 20 entries

Search:

Domain Name	Domain ID	Source
Antiviral_helicase_SKI2	PIRSF005198	PIRSF
DEAD	PF00270	Pfam
DEAD/DEAH_box_helicase_dom	IPR011545	InterPro
DEXDc	SM00487	SMART
DSHCT	PF08148	Pfam
DSHCT	SM01142	SMART
Helicase_ATP-bd	IPR014001	InterPro
HELICASE_ATP_BIND_1	PS51192	PROSITE
Helicase_C	IPR001650	InterPro
Helicase_C	PF00271	Pfam

Previous1 2Next