Protein: Q8N0Z3

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8N0Z3 (Uniprot) SPICE_HUMAN SPICE1 Spindle and centriole-associated protein 1 human No
Uniprot: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006725 cellular aromatic compound metabolic process 57 GO:0051641 cellular localization 872 2.74e-17 6.15e-158
GO:0006139 nucleobase-containing compound metabolic process 142 GO:0051641 cellular localization 872 4.17e-16 1.54e-157
GO:0044260 cellular macromolecule metabolic process 591, 714 GO:0051641 cellular localization 872 4.50e-03 3.02e-89
GO:0009059 macromolecule biosynthetic process 662 GO:0051641 cellular localization 872 1.95e-13 6.68e-127
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
3 GO:0022607 cellular component assembly
3 GO:0060255 regulation of macromolecule metabolic process
37 GO:0007165 signal transduction
57 GO:0006139 nucleobase-containing compound metabolic process
142 GO:0090304 nucleic acid metabolic process
142 GO:0060255 regulation of macromolecule metabolic process
275 GO:0022607 cellular component assembly
275 GO:0006796 phosphate-containing compound metabolic process
275 GO:0060255 regulation of macromolecule metabolic process
275 GO:0007165 signal transduction
294 GO:0000398 mRNA splicing, via spliceosome
419 GO:0022607 cellular component assembly
540 GO:0022607 cellular component assembly
591 GO:0016070 RNA metabolic process
591 GO:0010467 gene expression
591 GO:0060255 regulation of macromolecule metabolic process
608 GO:0060255 regulation of macromolecule metabolic process
662 GO:0034645 cellular macromolecule biosynthetic process
662 GO:0044271 cellular nitrogen compound biosynthetic process
662 GO:0090304 nucleic acid metabolic process
684 GO:0022402 cell cycle process
684 GO:0051640 organelle localization
714 GO:0016070 RNA metabolic process
714 GO:0010468 regulation of gene expression
835 GO:0022607 cellular component assembly
835 GO:0051640 organelle localization
872 GO:0051649 establishment of localization in cell
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
3 GO:0044430 cytoskeletal part
3 GO:0005829 cytosol
3 GO:0005634 nucleus
37 GO:0005829 cytosol
57 GO:0005634 nucleus
101 GO:0005829 cytosol
101 GO:0043232 intracellular non-membrane-bounded organelle
104 GO:0005829 cytosol
104 GO:0005815 microtubule organizing center
142 GO:0005634 nucleus
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
275 GO:0043232 intracellular non-membrane-bounded organelle
275 GO:0005634 nucleus
294 GO:0030529 intracellular ribonucleoprotein complex
294 GO:0005654 nucleoplasm
298 GO:0015630 microtubule cytoskeleton
365 GO:0015630 microtubule cytoskeleton
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
540 GO:0005829 cytosol
540 GO:0043232 intracellular non-membrane-bounded organelle
540 GO:0005634 nucleus
591 GO:0031981 nuclear lumen
600 GO:0005634 nucleus
608 GO:0043232 intracellular non-membrane-bounded organelle
608 GO:0005634 nucleus
631 GO:0044430 cytoskeletal part
631 GO:0005829 cytosol
631 GO:0015630 microtubule cytoskeleton
662 GO:0043232 intracellular non-membrane-bounded organelle
662 GO:0005634 nucleus
684 GO:0005829 cytosol
684 GO:0005815 microtubule organizing center
714 GO:0031981 nuclear lumen
835 GO:0044430 cytoskeletal part
835 GO:0005829 cytosol
835 GO:0015630 microtubule cytoskeleton
835 GO:0005654 nucleoplasm
872 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0046599 regulation of centriole replication IMP
GO:0051301 cell division IEA
GO:0051310 metaphase plate congression IMP
GO:0090307 mitotic spindle assembly IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005813 centrosome IDA
GO:0005814 centriole IDA
GO:0005819 spindle IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
MMTA2_HUMAN No
CP135_HUMAN Yes: Q66GS9 (MoonDB)
HAUS1_HUMAN No
SPAG5_HUMAN No
CC138_HUMAN No
RFC5_HUMAN No
SKA1_HUMAN No
FTM_HUMAN No
F161A_HUMAN No
CCD66_HUMAN No
PCM1_HUMAN Yes: Q15154 (MoonDB)
CE162_HUMAN No
CE128_HUMAN Yes: Q6ZU80 (MoonDB)
ADIP_HUMAN Yes: Q9Y2D8 (MoonDB)
AMOT_HUMAN No
ARI1B_HUMAN No
BAF_HUMAN No
BTF3_HUMAN No
C2CD3_HUMAN No
C2D1A_HUMAN No
CAMP1_HUMAN No
CAMP2_HUMAN No
CCD77_HUMAN No
CCNB1_HUMAN No
CE120_HUMAN Yes: Q8N960 (MoonDB)
CE295_HUMAN No
CE350_HUMAN No
CENPJ_HUMAN No
CEP44_HUMAN No
CEP55_HUMAN No
CEP72_HUMAN No
CEP85_HUMAN No
CEP95_HUMAN No
CFA97_HUMAN No
CKAP2_HUMAN No
CKP2L_HUMAN No
CLAP1_HUMAN No
CP131_HUMAN No
CSPP1_HUMAN No
DCLK1_HUMAN No
DDX54_HUMAN No
DIAP3_HUMAN No
ECH1_HUMAN No
EMAL4_HUMAN No
G6PI_HUMAN Yes: P06744 (MoonDB)
GARS_HUMAN No
GPC4_HUMAN No
GTPB1_HUMAN No
GTSE1_HUMAN No
HAUS2_HUMAN No
HAUS3_HUMAN No
HAUS4_HUMAN No
HAUS5_HUMAN No
HAUS6_HUMAN No
HAUS7_HUMAN No
HAUS8_HUMAN No
HMGN1_HUMAN No
HMMR_HUMAN Yes: O75330 (MoonDB)
IPO4_HUMAN No
IPO5_HUMAN No
IPO7_HUMAN No
IPO8_HUMAN No
KCRB_HUMAN No
KDM1A_HUMAN Yes: O60341 (MoonDB)
KIF14_HUMAN No
KIF2A_HUMAN No
KIF7_HUMAN No
LRC49_HUMAN No
LTV1_HUMAN No
LUZP1_HUMAN No
MA7D1_HUMAN No
MA7D2_HUMAN No
MA7D3_HUMAN No
MAP1S_HUMAN No
MAP7_HUMAN No
MAP9_HUMAN No
MCTS1_HUMAN No
MED4_HUMAN No
MOONR_HUMAN No
MPP9_HUMAN No
MTPN_HUMAN No
MTUS1_HUMAN No
NDC80_HUMAN No
NEDD1_HUMAN No
NH2L1_HUMAN No
NOL10_HUMAN No
NOP58_HUMAN No
NP1L1_HUMAN No
NP1L4_HUMAN No
NSA2_HUMAN No
OFD1_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
PDZ11_HUMAN No
PHIP_HUMAN No
PIBF1_HUMAN No
PKHA5_HUMAN No
RAB2A_HUMAN No
RAB35_HUMAN No
RALY_HUMAN No
RBM15_HUMAN No
RBMX_HUMAN No
RHG21_HUMAN No
RPF2_HUMAN No
SAMH1_HUMAN No
SEBP2_HUMAN No
SKA2_HUMAN No
SKA3_HUMAN No
SKAP_HUMAN No
SMG7_HUMAN No
SP16H_HUMAN No
SPC24_HUMAN No
SRP72_HUMAN No
SSRP1_HUMAN No
STXB1_HUMAN No
TAU_HUMAN No
TBC31_HUMAN No
TCHP_HUMAN No
TEX9_HUMAN No
TOP2A_HUMAN No
TOP2B_HUMAN No
TPGS1_HUMAN No
TRA2B_HUMAN No
TRI36_HUMAN No
TRI37_HUMAN No
TROAP_HUMAN No
TXLNG_HUMAN No
VP33B_HUMAN No
WRP73_HUMAN No
ZC21A_HUMAN No
PMID Article Title
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20736305 SPICE -- a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
SPICE1 IPR031387 InterPro
SPICE PF15678 Pfam