Protein: O75330

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O75330 (Uniprot) HMMR_HUMAN HMMR Hyaluronan mediated motility receptor human Yes
Uniprot: Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). more..
Dissimilar Functions Manual Curation

Function 1: Hyaluronan-binding protein with CD44-activating functions, controls signalling through RAS proteins. Condition: extracellular localisation.

Function 2: Mitotic spindle or centrosomal protein. Condition: nuclear localisation.

Publications (PMID): 18354082

Biological Processes
No results found.
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
GO:0030214 hyaluronan catabolic process TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0009986 cell surface IEA
GO:0016020 membrane IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005829 cytosol GO:0009986 cell surface 3.26e-22 6.81e-06
PMID Article Title
8890751 The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains.
9601098 The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15372022 The DNA sequence and comparative analysis of human chromosome 5.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18669648 A quantitative atlas of mitotic phosphorylation.
21269460 Initial characterization of the human central proteome.
22666460 ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
IHABP IPR026203 InterPro
HMMR_N IPR031787 InterPro
HMMR_C IPR031794 InterPro
JC5016 JC5016 PIR
HMMR_N PF15905 Pfam
HMMR_C PF15908 Pfam
PTHR18956 PTHR18956 PANTHER